Research map: Tocotrienol-rich fraction of vitamin E in diabetes and cardiovascular disease: From molecular mechanisms to clinical application

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Papers in this map

  1. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021 · Kanyin Liane Ong · 2023 · 4687 citations · Cited by this paper
  2. RETRACTED: Evaluation of the relationship between endothelial glycocalyx shedding and asymptomatic left ventricular diastolic dysfunction — a study based on a Chinese elderly physical examination cohort · 2026 · Related
  3. Economic Costs of Diabetes in the U.S. in 2022 · Emily D. Parker · 2023 · 804 citations · Cited by this paper
  4. Primary care diagnosed multimorbidity and risk of venous thromboembolism in Sweden · 2026 · Related
  5. Tocotrienols: Vitamin E beyond tocopherols · Chandan K. Sen · 2006 · 732 citations · Cited by this paper
  6. Sleep duration, blood pressure and cardiovascular outcomes in the middle-aged and the elderly · 2026 · Related
  7. Tocotrienols, the vitamin E of the 21st century: Its potential against cancer and other chronic diseases · Bharat Bhushan Aggarwal · 2010 · 568 citations · Cited by this paper
  8. Prevalence and spectrum of coronary artery anomalies detected on coronary CT angiography · 2026 · Related
  9. Association Between Healthy Eating Patterns and Risk of Cardiovascular Disease · Zhilei Shan · 2020 · 457 citations · Cited by this paper
  10. Association of coffee consumption with diabetes mellitus and gestational diabetes mellitus · 2026 · Related
  11. Tocotrienol: a review of its therapeutic potential · André Theriault · 1999 · 347 citations · Cited by this paper
  12. Oxidative balance score as a predictor of MASLD-CVD comorbidity risk and mortality: Insights from traditional and machine learning approaches · 2026 · Related
  13. Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds · Javad Sharifi‐Rad · 2020 · 287 citations · Cited by this paper
  14. Official proceeding from the 2025 ITACARE-P National Meeting, Rome, October 21-22 2025: The added value of Cardiovascular Rehabilitation in heart failure management: clinical scenarios and expert opinion from a centres network of the Italian Alliance for Cardiovascular Rehabilitation and Prevention (ITACARE-P) · 2026 · Related
  15. γ-Tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways · Wei Ney Yap · 2008 · 142 citations · Cited by this paper
  16. Associations between neighborhood socioeconomic status and cardiometabolic health among Asian American residents of New York city · 2026 · Related
  17. Vitamin E As a Potential Interventional Treatment for Metabolic Syndrome: Evidence from Animal and Human Studies · Sok Kuan Wong · 2017 · 136 citations · Cited by this paper
  18. Clinical landscape of gut microbiota modulators in cardiovascular disease therapy: Current status and future perspectives · 2025 · Related
  19. Tocotrienols: The promising analogues of vitamin E for cancer therapeutics · Bethsebie Lalduhsaki Sailo · 2018 · 133 citations · Cited by this paper
  20. Associations between various lipid indices and coronary collateral circulation in patients with acute ST-segment elevation myocardial infarction: a cross-sectional study · 2026 · Related
  21. Diabetic cardiomyopathy · Matthew M.Y. Lee · 2018 · 130 citations · Cited by this paper
  22. Influence of route of administration on the absorption and disposition of α,- γ- and δ-tocotrienols in rats · Siew Ping Yap · 2003 · 98 citations · Cited by this paper
  23. Diabetes: From Research to Clinical Practice · Md. Shahidul Islam · 2020 · 95 citations · Cited by this paper
  24. Vitamin E γ-Tocotrienol Inhibits Cytokine-Stimulated NF-κB Activation by Induction of Anti-Inflammatory A20 via Stress Adaptive Response Due to Modulation of Sphingolipids · Yun Wang · 2015 · 87 citations · Cited by this paper
  25. The Role of Tocotrienol in Protecting Against Metabolic Diseases · Kok-Lun Pang · 2019 · 84 citations · Cited by this paper
  26. Tocotrienol Suppresses Adipocyte Differentiation and Akt Phosphorylation in 3T3-L1 Preadipocytes · Harumi Uto‐Kondo · 2008 · 81 citations · Cited by this paper
  27. Efficacy of Oral Mixed Tocotrienols in Diabetic Peripheral Neuropathy · The Vitamin E in Neuroprotection Study (VENUS) Investigators · 2018 · 79 citations · Cited by this paper
  28. Pathophysiological Mechanisms of Diabetes-Induced Macrovascular and Microvascular Complications: The Role of Oxidative Stress · Bipradas Roy · 2025 · 71 citations · Cited by this paper
  29. Biological Properties of Tocotrienols: Evidence in Human Studies · Puvaneswari Meganathan · 2016 · 69 citations · Cited by this paper
  30. Evaluation of Pharmacokinetics, and Bioavailability of Higher Doses of Tocotrienols in Healthy Fed Humans · Asaf A. Qureshi · 2016 · 47 citations · Cited by this paper
  31. The global macroeconomic burden of diabetes mellitus · Simiao Chen · 2025 · 45 citations · Cited by this paper
  32. Advances in 3D Organoids and Organ‐on‐a‐Chip Systems for Biomedical Research · Vignesh Sakthivel · 2026 · 43 citations · Cited by this paper
  33. Furan-based chalcone protects β-cell damage and improves glucose uptake in alloxan-induced zebrafish diabetic model via influencing Peroxisome Proliferator-Activated Receptor agonists (PPAR-γ) signaling · S.P. Ramya Ranjan Nayak · 2024 · 42 citations · Cited by this paper
  34. Cardiovascular disease risk factors among older people: Data from the National Health and Morbidity Survey 2015 · Sazlina Shariff Ghazali · 2020 · 34 citations · Cited by this paper
  35. Palm oil tocotrienol fractions restore endothelium dependent relaxation in aortic rings of streptozotocin-induced diabetic and spontaneously hypertensive rats · Syed Putra Muharis · 2010 · 31 citations · Cited by this paper
  36. Fungal-Derived Chitosan Nanoparticles as Sustainable Soil Amendments, Improve Soil Quality, Enzymatic Activity, and Crop Productivity · G. S. Amrish Varshan · 2026 · 31 citations · Cited by this paper
  37. Emulsions as delivery systems for gamma and delta tocotrienols: Formation, properties and simulated gastrointestinal fate · Fei Xu · 2017 · 30 citations · Cited by this paper
  38. Associations of insulin resistance and beta-cell function with abnormal lipid profile in newly diagnosed diabetes · Xiaohan Tang · 2022 · 26 citations · Cited by this paper
  39. Energy substrate metabolism, mitochondrial structure and oxidative stress after cardiac ischemia-reperfusion in mice lacking UCP3 · Patricia Sánchez-Pérez · 2023 · 24 citations · Cited by this paper

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