Research map: Resistance development in KPC-producing Klebsiella pneumoniae under ceftazidime/avibactam-meropenem pressure: KPC-2 Ω-loop mutations attenuate avibactam efficacy

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  1. Origins and Evolution of Antibiotic Resistance · JULIAN E. DAVIES · 2010 · 5887 citations · Cited by this paper
  2. Antimicrobial Resistance Profile of Klebsiella pneumoniae Clinical Isolates at a Tertiary Pulmonology-Critical Care Centre in Romania: A Five-Year Retrospective Study (2021–2026) · Loredana Sabina Cornelia Manolescu · 2026 · Cites this paper
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  16. Ceftazidime-Avibactam: A Review in the Treatment of Serious Gram-Negative Bacterial Infections · Matt Shirley · 2018 · 387 citations · Cited by this paper
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  18. Global Threat of Carbapenem-Resistant Gram-Negative Bacteria · Shio‐Shin Jean · 2022 · 377 citations · Cited by this paper
  19. Phosphonium-based disinfectants are as effective as best-in-class quaternary ammonium compounds in the eradication of established biofilms in antibiotic-resistant bacteria · 2026 · Related
  20. Collateral sensitivity of antibiotic-resistant microbes · Csaba Pál · 2015 · 305 citations · Cited by this paper
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  22. Klebsiella pneumoniae Carbapenemase Variants Resistant to Ceftazidime-Avibactam: an Evolutionary Overview · Claire Amaris Hobson · 2022 · 228 citations · Cited by this paper
  23. Epidemiology of carbapenem-resistant Gram-negative infections globally · Adrian John Brink · 2019 · 222 citations · Cited by this paper
  24. Klebsiella pneumoniae carbapenemase variants: the new threat to global public health · Li Ding · 2023 · 221 citations · Cited by this paper
  25. Carbapenem-resistant Klebsiella pneumoniae capsular types, antibiotic resistance and virulence factors in China: a longitudinal, multi-centre study · Fupin Hu · 2024 · 202 citations · Cited by this paper
  26. New β-Lactamase Inhibitors in the Clinic · Krisztina M. Papp‐Wallace · 2016 · 167 citations · Cited by this paper
  27. Crystal Structure of KPC-2: Insights into Carbapenemase Activity in Class A β-Lactamases , · Wei Ke · 2007 · 141 citations · Cited by this paper
  28. Klebsiella pneumoniae Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering · Melissa D. Barnes · 2017 · 131 citations · Cited by this paper
  29. Emergence of ceftazidime/avibactam resistance in KPC-3-producing Klebsiella pneumoniae in vivo · Stephan Göttig · 2019 · 99 citations · Cited by this paper
  30. Inhibition of Klebsiella β-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study · Nikhil P. Krishnan · 2015 · 88 citations · Cited by this paper
  31. Successful Treatment of Bacteremia Due to NDM-1-Producing Morganella morganii with Aztreonam and Ceftazidime-Avibactam Combination in a Pediatric Patient with Hematologic Malignancy · Claire Amaris Hobson · 2018 · 63 citations · Cited by this paper
  32. Defining the architecture of KPC-2 Carbapenemase: identifying allosteric networks to fight antibiotics resistance · Ioannis Galdadas · 2018 · 57 citations · Cited by this paper
  33. Extensively Drug-Resistant Klebsiella pneumoniae Counteracts Fitness and Virulence Costs That Accompanied Ceftazidime-Avibactam Resistance Acquisition · Elias Eger · 2022 · 55 citations · Cited by this paper
  34. Activity of Ceftazidime-Avibactam Alone and in Combination with Ertapenem, Fosfomycin, and Tigecycline Against Carbapenemase-Producing Klebsiella pneumoniae · Dominika Ojdana · 2019 · 44 citations · Cited by this paper
  35. Potency of Vaborbactam Is Less Affected than That of Avibactam in Strains Producing KPC-2 Mutations That Confer Resistance to Ceftazidime-Avibactam · Ruslan Tsivkovski · 2020 · 43 citations · Cited by this paper
  36. Effect of ceftazidime/avibactam plus fosfomycin combination on 30 day mortality in patients with bloodstream infections caused by KPC-producing Klebsiella pneumoniae: results from a multicentre retrospective study · Alessandra Oliva · 2022 · 37 citations · Cited by this paper
  37. Ceftazidime-avibactam-based combination therapy for hospital-acquired central nervous system infections caused by carbapenem-resistant Klebsiella pneumoniae · Xiaoyu Zhao · 2023 · 32 citations · Cited by this paper
  38. Molecular mechanisms responsible KPC-135-mediated resistance to ceftazidime-avibactam in ST11-K47 hypervirulent Klebsiella pneumoniae · Qingyu Shi · 2024 · 32 citations · Cited by this paper
  39. Treatment and diagnosis of severe KPC-producing Klebsiella pneumoniae infections: a perspective on what has changed over last decades · Daniele Roberto Giacobbe · 2023 · 30 citations · Cited by this paper

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