Research map: Fasudil Attenuates Fluoride-induced Neuronal Synaptic Damage by Inhibiting Microglial Inflammation

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  1. RETRACTED: Neuroinflammatory Markers: Key Indicators in the Pathology of Neurodegenerative Diseases · Abdur Rauf · 2022 · 308 citations · Cited by this paper
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  13. miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease · Kai Zheng · 2021 · 102 citations · Cited by this paper
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  15. Excessive ER stress and the resulting autophagic flux dysfunction contribute to fluoride-induced neurotoxicity · Qiang Niu · 2017 · 95 citations · Cited by this paper
  16. Chronic nephrotoxicity and Nrf2-mediated oxidative stress response in zebrafish (Danio rerio) kidneys following environmentally relevant co-exposure to lead and chromium · 2026 · Related
  17. Fluoride Exposure and Children’s IQ Scores · Kyla W. Taylor · 2025 · 93 citations · Cited by this paper
  18. Benzo[a]pyrene toxicity: A critical review on long-term health impacts in aquatic species and humans · 2026 · Related
  19. AMPK/p38/Nrf2 activation as a protective feedback to restrain oxidative stress and inflammation in microglia stimulated with sodium fluoride · Chao Song · 2019 · 91 citations · Cited by this paper
  20. Neurotoxicity of 2,2’,4,4’-tetrabromodiphenyl ether (BDE-47) during embryonic zebrafish development · 2026 · Related
  21. GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome · Zhangjin Qin · 2022 · 73 citations · Cited by this paper
  22. A systematic review and meta-analysis of the association between fluoride exposure and neurological disorders · Giza Hellen Nonato Miranda · 2021 · 65 citations · Cited by this paper
  23. Advantages of Rho-associated kinases and their inhibitor fasudil for the treatment of neurodegenerative diseases · Bao‐Guo Xiao · 2022 · 65 citations · Cited by this paper
  24. Effect of exercise on microglial activation and transcriptome of hippocampus in fluorosis mice · Jixiang Wang · 2020 · 60 citations · Cited by this paper
  25. Effect of Selenium on Fluoride-Induced Changes in Synaptic Plasticity in Rat Hippocampus · Weijun Qian · 2013 · 50 citations · Cited by this paper
  26. Parthenolide modulates cerebral ischemia-induced microglial polarization and alleviates neuroinflammatory injury via the RhoA/ROCK pathway · Yehao Zhang · 2022 · 49 citations · Cited by this paper
  27. Atox1 protects hippocampal neurons after traumatic brain injury via DJ-1 mediated anti-oxidative stress and mitophagy · Pengzhan Zhao · 2024 · 47 citations · Cited by this paper
  28. Neonatal Sevoflurane Exposure Impairs Learning and Memory by the Hypermethylation of Hippocampal Synaptic Genes · Xinyu Fan · 2020 · 46 citations · Cited by this paper
  29. The effect of aged microglia on synaptic impairment and its relevance in neurodegenerative diseases · Juan José Triviño · 2021 · 43 citations · Cited by this paper
  30. Emodin protected against synaptic impairment and oxidative stress induced by fluoride in SH‐SY5Y cells by modulating ERK1 /2/Nrf2/ HO ‐1 pathway · Chencen Lai · 2020 · 41 citations · Cited by this paper
  31. Long-lasting restoration of memory function and hippocampal synaptic plasticity by focused ultrasound in Alzheimer's disease · Chanho Kong · 2023 · 39 citations · Cited by this paper
  32. Fluoride-Induced Expression of Neuroinflammatory Markers and Neurophysiological Regulation in the Brain of Wistar Rat Model · Yugandhar P. Reddy · 2020 · 38 citations · Cited by this paper
  33. Dietary Geranylgeranyl Pyrophosphate Counteracts the Benefits of Statin Therapy in Experimental Pulmonary Hypertension · Liping Zhu · 2021 · 35 citations · Cited by this paper
  34. Fluoride exposure disrupts the cytoskeletal arrangement and ATP synthesis of HT-22 cell by activating the RhoA/ROCK signaling pathway · Lingli Chen · 2023 · 34 citations · Cited by this paper
  35. Entorhinohippocampal cholecystokinin modulates spatial learning by facilitating neuroplasticity of hippocampal CA3-CA1 synapses · Junfeng Su · 2023 · 34 citations · Cited by this paper
  36. The influence of NQO2 on the dysfunctional autophagy and oxidative stress induced in the hippocampus of rats and in SH‐SY5Y cells by fluoride · Long‐Yan Ran · 2023 · 30 citations · Cited by this paper
  37. NaF-induced neurotoxicity via activation of the IL-1β/JNK signaling pathway · Chengzhi Zhang · 2022 · 27 citations · Cited by this paper
  38. Prolonged fluoride exposure induces spatial-memory deficit and hippocampal dysfunction by inhibiting small heat shock protein 22 in mice · Jinge Xin · 2023 · 26 citations · Cited by this paper
  39. Environmental enrichment combined with fasudil promotes motor function recovery and axonal regeneration after stroke · Yi Wu · 2021 · 24 citations · Cited by this paper

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