Research map: Myeloid-Specific Heparanase Aggravates Insulitis in Type 1 Diabetes via Heparan Sulfate Fragment-Dependent Amplification of Macrophage Polarization

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  1. Fast, sensitive and accurate integration of single-cell data with Harmony · Ilya Korsunsky · 2019 · 11385 citations · Cited by this paper
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  19. Polarizing Macrophages In Vitro · Xuan Huang · 2018 · 275 citations · Cited by this paper
  20. Effects of Pharmacological GIP Infusion on Insulin, Glucagon, and Cardiovascular Responses During Hyperglycemia in Type 2 Diabetes · 2026 · Related
  21. New Frontiers in the Treatment of Type 1 Diabetes · Jeremy T. Warshauer · 2019 · 262 citations · Cited by this paper
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  23. Soluble Heparan Sulfate Fragments Generated by Heparanase Trigger the Release of Pro-Inflammatory Cytokines through TLR-4 · Katharine Jennifer Goodall · 2014 · 228 citations · Cited by this paper
  24. Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy · Ralph D. Sanderson · 2016 · 228 citations · Cited by this paper
  25. NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP) · Klaus H. Kaestner · 2019 · 189 citations · Cited by this paper
  26. Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships · Peng Zhang · 2018 · 178 citations · Cited by this paper
  27. Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice · Javier A. Carrero · 2017 · 171 citations · Cited by this paper
  28. Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes · Andrew Ziolkowski · 2011 · 170 citations · Cited by this paper
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  30. Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes · Pavel N. Zakharov · 2020 · 152 citations · Cited by this paper
  31. Extracellular Matrix Components in the Pathogenesis of Type 1 Diabetes · Marika Bogdani · 2014 · 139 citations · Cited by this paper
  32. Loss of NADPH Oxidase–Derived Superoxide Skews Macrophage Phenotypes to Delay Type 1 Diabetes · Lindsey E. Padgett · 2014 · 108 citations · Cited by this paper
  33. Pancreatic cell tracing, lineage tagging and targeted genetic manipulations in multiple cell types using pancreatic ductal infusion of adeno-associated viral vectors and/or cell-tagging dyes · Xiangwei Xiao · 2014 · 90 citations · Cited by this paper
  34. Heparanase: A Challenging Cancer Drug Target · Deirdre R. Coombe · 2019 · 80 citations · Cited by this paper
  35. Coreceptor functions of cell surface heparan sulfate proteoglycans · Kazutaka Hayashida · 2022 · 66 citations · Cited by this paper
  36. Heparanase regulates the M1 polarization of renal macrophages and their crosstalk with renal epithelial tubular cells after ischemia/reperfusion injury · Valentina Masola · 2017 · 60 citations · Cited by this paper
  37. Heparanase, Heparan Sulfate and Viral Infection · Alex M. Agelidis · 2020 · 53 citations · Cited by this paper
  38. Helicobacter pylori-Induced Heparanase Promotes H. pylori Colonization and Gastritis · Li Tang · 2021 · 53 citations · Cited by this paper
  39. PI-88 and Related Heparan Sulfate Mimetics · Mohit Chhabra · 2020 · 43 citations · Cited by this paper

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