Research map: Photoaffinity Electrophoretic Mobility Shift Assay for Analyzing the Binding Specificity of DNA Aptamers to α-Thrombin

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  1. Selection of single-stranded DNA molecules that bind and inhibit human thrombin · Louis C. Bock · 1992 · 2482 citations · Cited by this paper
  2. Asymmetric Conjugate Addition of Thiophene Derivative to Nitrostyrenes Using Thiourea Organocatalysts · 2026 · Related
  3. Aptamers evolved from live cells as effective molecular probes for cancer study · Dihua Shangguan · 2006 · 1517 citations · Cited by this paper
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  5. The refined 1.9 A crystal structure of human alpha‐thrombin: interaction with D‐Phe‐Pro‐Arg chloromethylketone and significance of the Tyr‐Pro‐Pro‐Trp insertion segment. · Wolfram Bode · 1989 · 894 citations · Cited by this paper
  6. Spectroscopic Analysis of Salicylate Dianion Generated during Aspirin Titration Based on the Japanese Pharmacopoeia Method · 2026 · Related
  7. Thrombin-binding DNA aptamer forms a unimolecular quadruplex structure in solution. · Román F. Macaya · 1993 · 887 citations · Cited by this paper
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  9. Oligonucleotide inhibitors of human thrombin that bind distinct epitopes · Diane M. Tasset · 1997 · 850 citations · Cited by this paper
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  13. The role of phospholipids and factor Va in the prothrombinase complex. · Jan Rosing · 1980 · 676 citations · Cited by this paper
  14. Screening the Human Proteome for Peptides Targeting the Acidic Environment of Tumor Tissues · 2026 · Related
  15. In Vitro Evolution of Functional DNA Using Capillary Electrophoresis · Shaun D. Mendonsa · 2003 · 423 citations · Cited by this paper
  16. Rigid Benzene Ring Substitution of Capsaicin’s Double Bond: Synthesis of TRPV1 Agonist with Anti-fatigue Efficacy · 2026 · Related
  17. “Normal” Thrombin Generation · Saulius Butenas · 1999 · 383 citations · Cited by this paper
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  19. Nucleic Acid and Peptide Aptamers: Fundamentals and Bioanalytical Aspects · Marco Mascini · 2011 · 369 citations · Cited by this paper
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  21. Thrombin · Enrico Di · 2008 · 339 citations · Cited by this paper
  22. Activation of human prothrombin by human prothrombinase. Influence of factor Va on the reaction mechanism. · Sriram Krishnaswamy · 1987 · 282 citations · Cited by this paper
  23. Quantitative characterization of the thrombin-heparin interaction. Discrimination between specific and nonspecific binding models. · Steven T. Olson · 1991 · 233 citations · Cited by this paper
  24. Screening for N ‐glycosylated proteins by liquid chromatography mass spectrometry · Jakob Bunkenborg · 2004 · 186 citations · Cited by this paper
  25. Molecular mapping of the heparin-binding exosite of thrombin. · John P. Sheehan · 1994 · 174 citations · Cited by this paper
  26. The transition of prothrombin to thrombin · Sriram Krishnaswamy · 2013 · 170 citations · Cited by this paper
  27. Crystal Structure of Thrombin Bound to Heparin · Wendy J. Carter · 2004 · 162 citations · Cited by this paper
  28. Thrombin–aptamer recognition: a revealed ambiguity · Irene Russo Krauss · 2011 · 160 citations · Cited by this paper
  29. The COOH-terminal domain of hirudin. An exosite-directed competitive inhibitor of the action of alpha-thrombin on fibrinogen. · Michael C. Naski · 1990 · 148 citations · Cited by this paper
  30. The isomorphous structures of prethrombin2, hirugen–, and PPACK–thrombin: Changes accompanying activation and exosite binding to thrombin · J. Vijayalakshmi · 1994 · 146 citations · Cited by this paper
  31. New Insights into Aptamers: An Alternative to Antibodies in the Detection of Molecular Biomarkers · Michaela Domšicová · 2024 · 134 citations · Cited by this paper
  32. Generative aptamer discovery using RaptGen · Natsuki Iwano · 2022 · 116 citations · Cited by this paper
  33. Duplex–quadruplex motifs in a peculiar structural organization cooperatively contribute to thrombin binding of a DNA aptamer · Irene Russo Krauss · 2013 · 103 citations · Cited by this paper
  34. G-quadruplex-based aptamers targeting human thrombin: Discovery, chemical modifications and antithrombotic effects · Claudia Riccardi · 2020 · 97 citations · Cited by this paper
  35. Prothrombin activation on the activated platelet surface optimizes expression of procoagulant activity · Jeremy P. Wood · 2010 · 80 citations · Cited by this paper
  36. Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity · Rafał Dolot · 2018 · 80 citations · Cited by this paper
  37. HD1, a Thrombin-directed Aptamer, Binds Exosite 1 on Prothrombin with High Affinity and Inhibits Its Activation by Prothrombinase · Colin A. Kretz · 2006 · 75 citations · Cited by this paper
  38. The Discovery of Dabigatran Etexilate · Joanne van Ryn · 2013 · 73 citations · Cited by this paper
  39. Simple and Versatile Method for Tagging Phenyldiazirine Photophores · Hiroyuki Nakashima · 2006 · 70 citations · Cited by this paper

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