Research map: IMB-A3, an isoindolinone derivative, functions as a molecular glue to promote CRBN-mediated ubiquitination and degradation of enterovirus A71 2C protein

Back to the article

Papers in this map

  1. Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ · James E. Brownell · 2010 · 471 citations · Cited by this paper
  2. Envelope protein residue E152 confers enhanced GAS6-dependent cell entry to the African Zika virus strain MR766 · 2026 · Related
  3. Enterovirus 71 Protease 2Apro Targets MAVS to Inhibit Anti-Viral Type I Interferon Responses · Bei Wang · 2013 · 239 citations · Cited by this paper
  4. Recombinant polyclonal antibody GIGA-2339 potently and pan-genotypically neutralizes hepatitis B virus · 2026 · Related
  5. Molecular glues for protein-protein interactions: Progressing toward a new dream · Markella Konstantinidou · 2024 · 184 citations · Cited by this paper
  6. Fluorescence polarization–based high-throughput screening identifies SAM-competitive inhibitors of monkeypox virus N7-methyltransferase · 2026 · Related
  7. Enterovirus 71 infection and neurological complications · Kyung Yeon Lee · 2016 · 155 citations · Cited by this paper
  8. Human monoclonal antibodies from donors vaccinated with recombinant vaccinia vaccine targeting A35 and B6 effectively inhibit orthopoxvirus spread and infection · 2026 · Related
  9. Neural pathogenesis of enterovirus 71 infection · Kuo‐Feng Weng · 2010 · 147 citations · Cited by this paper
  10. Nanoparticles in viral pneumonia: diagnosis, therapy, and prevention · 2026 · Related
  11. Enterovirus 71: epidemiology, pathogenesis and management · Shih-Min Wang · 2009 · 130 citations · Cited by this paper
  12. A subset of histamine H4 receptor antagonists prevents B lymphocyte proliferation induced by BCR/TLR9 engagement or EBV infection · 2026 · Related
  13. Effective degradation of EGFRL858R+T790M mutant proteins by CRBN-based PROTACs through both proteosome and autophagy/lysosome degradation systems · Xiaojuan Qu · 2021 · 116 citations · Cited by this paper
  14. A stapled viral peptide blocks HSV-2 from infecting human cervical cells · 2026 · Related
  15. Crystal structure of 2C helicase from enterovirus 71 · Hongxin Guan · 2017 · 80 citations · Cited by this paper
  16. Human cytomegalovirus terminase inhibitors letermovir, tomeglovir, and the halogenated benzimidazoles modify DNA cleavage/packaging to generate a super-genomic DNA species by cleavage site skipping · 2026 · Related
  17. Cereblon covalent modulation through structure-based design of histidine targeting chemical probes · Justin T. Cruite · 2022 · 76 citations · Cited by this paper
  18. Cell-type specific effects of SARS-CoV-2 P252L mutation on nirmatrelvir sensitivity · 2026 · Related
  19. The Structure, Function, and Mechanisms of Action of Enterovirus Non-structural Protein 2C · Shaohua Wang · 2020 · 68 citations · Cited by this paper
  20. Neutralizing antibodies as A therapy for hepatitis E virus: Advances, challenges and opportunities · 2026 · Related
  21. Recent Progress on Functional Genomics Research of Enterovirus 71 · Huiqiang Wang · 2018 · 65 citations · Cited by this paper
  22. Targeting cereblon in hematologic malignancies · Ota Fuchs · 2022 · 56 citations · Cited by this paper
  23. The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair · Dudley Chung · 2015 · 50 citations · Cited by this paper
  24. Clinical characteristics and managements of severe hand, foot and mouth disease caused by enterovirus A71 and coxsackievirus A16 in Shanghai, China · Kang Cai · 2019 · 50 citations · Cited by this paper
  25. Identification of dibucaine derivatives as novel potent enterovirus 2C helicase inhibitors: In vitro, in vivo, and combination therapy study · Qi Tang · 2020 · 49 citations · Cited by this paper
  26. Advances in anti-EV-A71 drug development research · Shuqi Wang · 2023 · 48 citations · Cited by this paper
  27. Molecular Epidemiology of Enterovirus 71 Infection in the Central Region of Taiwan from 2002 to 2012 · Wen-Hao Wu · 2013 · 47 citations · Cited by this paper
  28. An adenosine nucleoside analogue NITD008 inhibits EV71 proliferation · Luqing Shang · 2014 · 44 citations · Cited by this paper
  29. PROTACs, molecular glues and bifunctionals from bench to bedside: Unlocking the clinical potential of catalytic drugs · Marı́a Maneiro · 2021 · 43 citations · Cited by this paper
  30. Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex · Daniel L. Hurdiss · 2022 · 40 citations · Cited by this paper
  31. Repurposing carrimycin as an antiviral agent against human coronaviruses, including the currently pandemic SARS-CoV-2 · Haiyan Yan · 2021 · 38 citations · Cited by this paper
  32. Development of broad-spectrum enterovirus antivirals based on quinoline scaffold · Rami Ghassan Musharrafieh · 2020 · 37 citations · Cited by this paper
  33. Antiviral Peptides Targeting the Helicase Activity of Enterovirus Nonstructural Protein 2C · Yuan Fang · 2021 · 35 citations · Cited by this paper
  34. Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C · Lisa M. Bauer · 2020 · 34 citations · Cited by this paper
  35. Recent Advances in Enterovirus A71 Infection and Antiviral Agents · Yanhong Wei · 2023 · 25 citations · Cited by this paper
  36. Antigenic characteristics of the complete and truncated capsid protein VP1 of enterovirus 71 · Jianhua Zhang · 2012 · 23 citations · Cited by this paper
  37. EV71 3C protease cleaves host anti-viral factor OAS3 and enhances virus replication · Xiaolei Zhou · 2022 · 22 citations · Cited by this paper
  38. Crbn-based molecular Glues: Breakthroughs and perspectives · Juzeng An · 2024 · 20 citations · Cited by this paper
  39. Identification of a novel acylthiourea-based potent broad-spectrum inhibitor for enterovirus 3D polymerase in vitro and in vivo · Xinjin Liu · 2023 · 17 citations · Cited by this paper

Source: OpenAlex (CC0)