Research map: Resetting immunometabolic set points in autoimmune disease

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  1. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update · Josef S Smolen · 2017 · 7417 citations · Cited by this paper
  2. Systemic lupus pregnancies are characterized by an intrinsic pro-inflammatory monocyte transcriptome, driven by an aberrant miRNA signature · 2025 · Related
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  7. Defining trained immunity and its role in health and disease · Mihai Gheorghe Netea · 2020 · 2715 citations · Cited by this paper
  8. Short-chain fatty acids from gut microbiota restore Th17/Treg balance in rheumatoid arthritis: Mechanisms and therapeutic potential · 2025 · Related
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  10. Serum test for secretory component-containing anti-citrullinated protein antibodies as a novel prognostic tool in rheumatoid arthritis at-risk subjects · 2025 · Related
  11. ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation · Kathryn E. Wellen · 2009 · 2334 citations · Cited by this paper
  12. Extracellular vesicles and their role in Lupus Nephritis: A scoping review · 2026 · Related
  13. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 · Evanna L. Mills · 2018 · 1944 citations · Cited by this paper
  14. Antinuclear antibody targets in autoimmune hepatitis and drug-induced liver injury: Diagnostic relevance of nucleosome antibodies · 2026 · Related
  15. Disease Tolerance as a Defense Strategy · Ruslan M. Medzhitov · 2012 · 1774 citations · Cited by this paper
  16. Atypical Wiskott-Aldrich syndrome presenting with normal platelet volume and end-stage renal disease: from misdiagnosis as ITP to combined transplantation · 2026 · Related
  17. Eicosanoid storm in infection and inflammation · Edward A. Dennis · 2015 · 1546 citations · Cited by this paper
  18. Microbiota-derived metabolites in inflammatory bowel disease · 2025 · Related
  19. Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry · Fan Zhang · 2019 · 1466 citations · Cited by this paper
  20. Lupus nephritis · Hans‐Joachim Anders · 2020 · 972 citations · Cited by this paper
  21. Itaconate: the poster child of metabolic reprogramming in macrophage function · Luke A.J. O'Neill · 2019 · 658 citations · Cited by this paper
  22. Targeting immunometabolism as an anti-inflammatory strategy · Eva M. Pålsson‐McDermott · 2020 · 601 citations · Cited by this paper
  23. Mechanisms of human autoimmunity · Michael D. Rosenblum · 2015 · 519 citations · Cited by this paper
  24. Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach · Yoshiya Tanaka · 2022 · 503 citations · Cited by this paper
  25. Multistep Pathogenesis of Autoimmune Disease · Christopher Carl Goodnow · 2007 · 431 citations · Cited by this paper
  26. Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial · Zhi‐Wei Lai · 2018 · 416 citations · Cited by this paper
  27. Immune regulation through tryptophan metabolism · Su‐Kil Seo · 2023 · 394 citations · Cited by this paper
  28. Metabolic regulation of the immune system in health and diseases: mechanisms and interventions · Tengyue Hu · 2024 · 368 citations · Cited by this paper
  29. EULAR points to consider for the management of difficult-to-treat rheumatoid arthritis · György Nagy · 2021 · 294 citations · Cited by this paper
  30. A physiologist's view of homeostasis · Harold I. Modell · 2015 · 282 citations · Cited by this paper
  31. Lactate: A key regulator of the immune response · Alba Llibre · 2025 · 271 citations · Cited by this paper
  32. A graph neural network model to estimate cell-wise metabolic flux using single-cell RNA-seq data · Norah Alghamdi · 2021 · 257 citations · Cited by this paper
  33. Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders · Yi Song · 2024 · 249 citations · Cited by this paper
  34. Cellular metabolism regulates the differentiation and function of T-cell subsets · Sicong Ma · 2024 · 233 citations · Cited by this paper
  35. Survival of Long-Lived Plasma Cells (LLPC): Piecing Together the Puzzle · Shivana M. Lightman · 2019 · 211 citations · Cited by this paper
  36. Dietary cholesterol promotes repair of demyelinated lesions in the adult brain · Stefan A. Berghoff · 2017 · 151 citations · Cited by this paper
  37. Regulatory T cells in homeostasis and disease: molecular mechanisms and therapeutic potential · Lingling Wang · 2025 · 141 citations · Cited by this paper
  38. Hematopoietic Stem Cell Transplantation for Autoimmune Disease · Tobias Alexander · 2020 · 106 citations · Cited by this paper
  39. Flares after hydroxychloroquine reduction or discontinuation: results from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort · Celline Cardoso Almeida-Brasil · 2021 · 103 citations · Cited by this paper

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