Research map: Frailty before chronic disease: multisystem physiological differences in middle-aged adults from the UK Biobank

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  1. Frailty in Older Adults: Evidence for a Phenotype · Linda P. Fried · 2001 · 25176 citations · Cited by this paper
  2. Joint effects of social determinants of health on NAFLD mortality: the mediating role of phenotypic age acceleration · 2026 · Related
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  6. Auditory and executive determinants of phonetic processing and lexical acquisition in older adults with mild hearing impairment and cognitive decline · 2026 · Related
  7. Prevalence of Frailty in Community‐Dwelling Older Persons: A Systematic Review · Rose M. Collard · 2012 · 3156 citations · Cited by this paper
  8. Longitudinal association between dietary quality trajectories and cognitive frailty in older adults: a 12-year study of the TIGER cohort · 2026 · Related
  9. Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants · Peter Hanlon · 2018 · 1320 citations · Cited by this paper
  10. Multimodal MRI prediction of cognitive functioning across the lifespan: separating between-person differences from within-person changes · 2026 · Related
  11. Sarcopenic obesity: definition, cause and consequences · Sari Stenholm · 2008 · 1083 citations · Cited by this paper
  12. Age-related differences in motor unit discharge rate modulation across contraction levels · 2026 · Related
  13. Frailty and Multimorbidity: A Systematic Review and Meta-analysis · Davide Liborio Vetrano · 2018 · 837 citations · Cited by this paper
  14. Age- and sex- related patterns in hematobiochemical and anthropometric parameters of Macaca monkeys · 2026 · Related
  15. Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases · Ana Luísa Cardoso · 2018 · 500 citations · Cited by this paper
  16. Micronutrients and omega-3 PUFAs to promote healthy ageing: informing a physiology-based complementation strategy · 2026 · Related
  17. Delaying and reversing frailty: a systematic review of primary care interventions · John F. Travers · 2018 · 420 citations · Cited by this paper
  18. Sensory impairment, epigenetic ageing, and later-life functional decline and mortality in older adults · 2026 · Related
  19. A Race-neutral Approach to the Interpretation of Lung Function Measurements · Cole Bowerman · 2022 · 410 citations · Cited by this paper
  20. Associations of IL-17 and TGF-β1 with physical frailty in older adults · 2026 · Related
  21. Endocrine and inflammatory markers as predictors of frailty · Martine T.E. Puts · 2005 · 319 citations · Cited by this paper
  22. Relation of C-Reactive Protein to Abdominal Adiposity · Gabriel C. Brooks · 2010 · 265 citations · Cited by this paper
  23. Abdominal obesity, body mass index and the risk of frailty in community-dwelling older adults: a systematic review and meta-analysis · Linli Yuan · 2021 · 258 citations · Cited by this paper
  24. Cardiovascular risk profile and frailty in a population-based study of older British men · Sheena E Ramsay · 2014 · 201 citations · Cited by this paper
  25. Association of inflammatory mediators with frailty status in older adults: results from a systematic review and meta-analysis · Diego Marcos-Pérez · 2020 · 186 citations · Cited by this paper
  26. Associations of neutrophil and monocyte counts with frailty in community-dwelling disabled older women: Results from the Women’s Health and Aging Studies I · Sean Xiao Leng · 2009 · 166 citations · Cited by this paper
  27. Hyperglycemia and Incidence of Frailty and Lower Extremity Mobility Limitations in Older Women · Rita Rastogi Kalyani · 2012 · 159 citations · Cited by this paper
  28. Inflammatory biomarkers in older adults with frailty: a systematic review and meta-analysis of cross-sectional studies · Yushuang Xu · 2022 · 131 citations · Cited by this paper
  29. Glucose Levels and Risk of Frailty · Oleg Zaslavsky · 2016 · 123 citations · Cited by this paper
  30. Associations of physical frailty with health outcomes and brain structure in 483 033 middle-aged and older adults: a population-based study from the UK Biobank · Rongtao Jiang · 2023 · 116 citations · Cited by this paper
  31. Is Hyperglycemia Associated with Frailty Status in Older Women? · Caroline S. Blaum · 2009 · 99 citations · Cited by this paper
  32. Circulating biomarkers characterizing physical frailty: CRP, hemoglobin, albumin, 25OHD and free testosterone as best biomarkers. Results of a meta-analysis · Aurélie Mailliez · 2020 · 84 citations · Cited by this paper
  33. Association of Frailty and Cardiometabolic Risk Among Community-Dwelling Middle-Aged and Older People: Results from the I-Lan Longitudinal Aging Study · An‐Chun Hwang · 2015 · 55 citations · Cited by this paper
  34. Blood pressure in relation to frailty in older adults: A population‐based study · Daniela Anker · 2019 · 54 citations · Cited by this paper
  35. Blood Pressure in Older Adults: the Importance of Frailty · Michelle C. Odden · 2015 · 53 citations · Cited by this paper
  36. Association Between Insulin-Like Growth Factor-1 and Frailty Among Older Adults · Takehiko Doi · 2017 · 52 citations · Cited by this paper
  37. Frailty predicts short-term survival even in older adults without multimorbidity · Alberto Zucchelli · 2018 · 51 citations · Cited by this paper
  38. Menopause and frailty: a scoping review · Haihui Ruan · 2020 · 51 citations · Cited by this paper
  39. Associations between air pollution and multimorbidity in the UK Biobank: A cross-sectional study · Amy Ronaldson · 2022 · 47 citations · Cited by this paper

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