Research map: Helper-Dependent Adenoviral Vectors: Recent Advances and Emerging Applications

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Papers in this map

  1. Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5 · Jeffrey M. Bergelson · 1997 · 3113 citations · Cited by this paper
  2. Retroviral Transduction of Human CD4 + T Cells with Membrane-Attached IL-10 Generates Type 1-Like Regulatory T Cells · 2026 · Related
  3. Gene therapy returns to centre stage · Luigi Naldini · 2015 · 1190 citations · Cited by this paper
  4. Optimization of Alpha-1 Antitrypsin Expression from Adeno-Associated Virus Vectors · 2026 · Related
  5. Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates · Lajos Mátés · 2009 · 1010 citations · Cited by this paper
  6. Prenatal Intraportal Delivery of Polymeric Nanoparticles to Fetal Rhesus Monkeys ( Macaca mulatta ) · 2026 · Related
  7. CD46 is a cellular receptor for group B adenoviruses · Anuj Gaggar · 2003 · 799 citations · Cited by this paper
  8. High Prevalence of Preexisting Neutralizing Antibodies Against Adeno-Associated Virus Capsids in Mongolian People with Hemophilia · 2026 · Related
  9. A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal · Robin J. Parks · 1996 · 725 citations · Cited by this paper
  10. Quantification of Lentiviral Vectors with Nucleic Acid Dyes · 2026 · Related
  11. Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity · Gudrun Schiedner · 1998 · 653 citations · Cited by this paper
  12. CAR-T Cell Therapy: Manufacturing Platforms and Clinical Consequences · 2026 · Related
  13. Desmosome structure, composition and function · David R. Garrod · 2007 · 591 citations · Cited by this paper
  14. A Review of the Challenge of Pre-Existing Humoral Immunity in Adeno-Associated Virus Gene Therapy and Potential Solutions · 2026 · Related
  15. Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14 · Hongjie Wang · 2010 · 438 citations · Cited by this paper
  16. Capsid Engineering of Adeno-Associated Viruses for Targeted Gene Therapy in Kidney Diseases · 2026 · Related
  17. Molecular basis of the inflammatory response to adenovirus vectors · Qianyuan Liu · 2003 · 430 citations · Cited by this paper
  18. Ethical and Regulatory Considerations for Developing Gene Therapies Involving Genome Editing · 2026 · Related
  19. The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors · André Lieber · 1997 · 415 citations · Cited by this paper
  20. Genome-replicating HC-AdV: A novel high-capacity adenoviral vector class featuring enhanced in situ payload expression · 2025 · Related
  21. Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons · Núria Morral · 1999 · 411 citations · Cited by this paper
  22. AAV vectors: The Rubik’s cube of human gene therapy · Amaury Pupo · 2022 · 380 citations · Cited by this paper
  23. Efficient Gene Transfer into Human CD34 + Cells by a Retargeted Adenovirus Vector · Dmitry M. Shayakhmetov · 2000 · 366 citations · Cited by this paper
  24. Adenovirus: The First Effective In Vivo Gene Delivery Vector · Ronald G. Crystal · 2014 · 338 citations · Cited by this paper
  25. Improved system for helper-dependent adenoviral vector production · Donna J Palmer · 2003 · 320 citations · Cited by this paper
  26. Acute Toxicity After High-Dose Systemic Injection of Helper-Dependent Adenoviral Vectors into Nonhuman Primates · Nicola Brunetti‐Pierri · 2004 · 257 citations · Cited by this paper
  27. Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: Toward realistic long-term neurological gene therapy for chronic diseases · Clare E. Thomas · 2000 · 254 citations · Cited by this paper
  28. Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector · In-Hoo Kim · 2001 · 223 citations · Cited by this paper
  29. Adenovirus receptors: implications for targeting of viral vectors · Niklas Arnberg · 2012 · 201 citations · Cited by this paper
  30. Helper-Dependent Adenovirus Vectors Elicit Intact Innate but Attenuated Adaptive Host Immune Responses In Vivo · Daniel A. Muruve · 2004 · 198 citations · Cited by this paper
  31. A review of 65 years of human adenovirus seroprevalence · Franck J. D. Mennechet · 2019 · 191 citations · Cited by this paper
  32. Transposition from a gutless adeno-transposon vector stabilizes transgene expression in vivo · Stephen R. Yant · 2002 · 187 citations · Cited by this paper
  33. High-Capacity Adenoviral Vectors for Gene Transfer and Somatic Gene Therapy · Stefan Kochanek · 1999 · 172 citations · Cited by this paper
  34. A New Group B Adenovirus Receptor Is Expressed at High Levels on Human Stem and Tumor Cells · Sebastian Tuve · 2006 · 154 citations · Cited by this paper
  35. Efficient FLPe recombinase enables scalable production of helper-dependent adenoviral vectors with negligible helper-virus contamination · Pablo Umaña · 2001 · 142 citations · Cited by this paper
  36. A new adenoviral helper–dependent vector results in long-term therapeutic levels of human coagulation factor IX at low doses in vivo · Anja Ehrhardt · 2002 · 140 citations · Cited by this paper
  37. Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector · Gabriele Toietta · 2005 · 140 citations · Cited by this paper
  38. Targeting of Adenovirus to Endothelial Cells by a Bispecific Single-Chain Diabody Directed against the Adenovirus Fiber Knob Domain and Human Endoglin (CD105) · Dirk M. Nettelbeck · 2001 · 118 citations · Cited by this paper
  39. Long‐term in vivo transduction of neurons throughout the rat central nervous system using novel helper‐dependent CAV‐2 vectors · Claire Soudais · 2003 · 113 citations · Cited by this paper

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