Research map: Comparing synthetic and biological therapy for the treatment of cluster headache: what is needed and when?

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  1. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition · 2018 · 10870 citations · Cited by this paper
  2. Medication-overuse headache: can anti-CGRP monoclonal antibodies replace withdrawal? · 2025 · Related
  3. Hypothalamic activation in cluster headache attacks · Arne May · 1998 · 1128 citations · Cited by this paper
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  5. Human in vivo evidence for trigeminovascular activation in cluster headache Neuropeptide changes and effects of acute attacks therapies · Peter James Goadsby · 1994 · 682 citations · Cited by this paper
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  7. The Incidence and Prevalence of Cluster Headache: A Meta-Analysis of Population-Based Studies · Marthe Fischera · 2008 · 457 citations · Cited by this paper
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  9. Treatment of Acute Cluster Headache with Sumatriptan · The Sumatriptan Cluster Headache Study Group* · 1991 · 430 citations · Cited by this paper
  10. Building a new arsenal: repurposed drugs and metronomic chemotherapy against medulloblastoma · 2026 · Related
  11. Cluster headache: pathogenesis, diagnosis, and management · Arne May · 2005 · 382 citations · Cited by this paper
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  13. Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: A randomized, sham-controlled study · Jean E. Schoenen · 2013 · 358 citations · Cited by this paper
  14. The latest views on how vagus nerve stimulation works in epilepsy: a plain language summary · 2025 · Related
  15. Suboccipital injection with a mixture of rapid- and long-acting steroids in cluster headache: A double-blind placebo-controlled study · Anna Ambrosini · 2005 · 339 citations · Cited by this paper
  16. Advances in targeted closed loop spinal cord stimulation to treat pain of the trunk and limbs · 2026 · Related
  17. High-Flow Oxygen for Treatment of Cluster Headache · Anna S. Cohen · 2009 · 316 citations · Cited by this paper
  18. Speech and language outcome measures in clinical trials of Alzheimer’s and Parkinson’s diseases · 2025 · Related
  19. Melatonin Versus Placebo in the Prophylaxis of Cluster Headache · Massimo Leone · 1996 · 310 citations · Cited by this paper
  20. High flow versus ultra-high flow (demand valve) oxygen delivery in cluster headache: A patient experience survey by the Organization for Understanding Cluster Headache-UK ( OUCH-UK ) · 2025 · Related
  21. Response of Cluster Headache Attacks to Oxygen Inhalation · Lee Kudrow · 1981 · 264 citations · Cited by this paper
  22. Trial of Galcanezumab in Prevention of Episodic Cluster Headache · Peter James Goadsby · 2019 · 260 citations · Cited by this paper
  23. Treatment of Cluster Headache: The American Headache Society Evidence‐Based Guidelines · Matthew S. Robbins · 2016 · 258 citations · Cited by this paper
  24. Verapamil in the prophylaxis of episodic cluster headache: A double-blind study versus placebo · Massimo Leone · 2000 · 234 citations · Cited by this paper
  25. Double Blind Comparison of Lithium and Verapamil in Cluster Headache Prophylaxis · Gennaro Bussone · 1990 · 230 citations · Cited by this paper
  26. Suboccipital steroid injections for transitional treatment of patients with more than two cluster headache attacks per day: a randomised, double-blind, placebo-controlled trial · Élizabeth Leroux · 2011 · 206 citations · Cited by this paper
  27. Subcutaneous sumatriptan in the acute treatment of cluster headache: a dose comparison study · Kerstin Ekbom · 2009 · 190 citations · Cited by this paper
  28. A phase 2, randomized, double-blind, placebo-controlled trial of AMG 301, a pituitary adenylate cyclase-activating polypeptide PAC1 receptor monoclonal antibody for migraine prevention · Messoud Ashina · 2020 · 160 citations · Cited by this paper
  29. Phase 3 randomized, placebo-controlled study of galcanezumab in patients with chronic cluster headache: Results from 3-month double-blind treatment · David W. Dodick · 2020 · 157 citations · Cited by this paper
  30. Prophylactic Treatment of Cluster Headache with Verapamil · Ivy J. Gabai · 1989 · 153 citations · Cited by this paper
  31. Effectiveness of Intranasal Zolmitriptan in Acute Cluster Headache · E. Cittadini · 2006 · 152 citations · Cited by this paper
  32. Effect of Infusion of Calcitonin Gene-Related Peptide on Cluster Headache Attacks · Anne Luise Haulund Vollesen · 2018 · 147 citations · Cited by this paper
  33. Oxygen Inhibits Neuronal Activation in the Trigeminocervical Complex After Stimulation of Trigeminal Autonomic Reflex, But Not During Direct Dural Activation of Trigeminal Afferents · Simon Akerman · 2009 · 140 citations · Cited by this paper
  34. Double-Blind Placebo-Controlled Trial of Lithium in Episodic Cluster Headache · TJ Steiner · 1997 · 140 citations · Cited by this paper
  35. Electrocardiographic abnormalities in patients with cluster headache on verapamil therapy · Anna S. Cohen · 2007 · 133 citations · Cited by this paper
  36. Lithium Prophylaxis for Chronic Cluster Headache · Lee Kudrow · 1977 · 124 citations · Cited by this paper
  37. Topiramate-treated cluster headache · Steve D. Wheeler · 1999 · 124 citations · Cited by this paper
  38. PACAP and its role in primary headaches · Lars IH Edvinsson · 2018 · 120 citations · Cited by this paper
  39. Melatonin as Adjunctive Therapy in the Prophylaxis of Cluster Headache: A Pilot Study · Tamara Milka Pringsheim · 2002 · 105 citations · Cited by this paper

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