Research map: Pridopidine Mediated Sigma-1 Receptor Activation and Therapeutic Implications in Neurodegenerative Diseases

Back to the article

Papers in this map

  1. Huntington's disease · Francis O. Walker · 2007 · 2634 citations · Cited by this paper
  2. A Global Burden Perspective on Obstructive Sleep Apnea, Hearing Loss, and Early-Onset Cognitive Decline · 2026 · Related
  3. Amyotrophic Lateral Sclerosis · Robert H. Brown · 2017 · 2199 citations · Cited by this paper
  4. Motor Nerve Transfers in Complete and Incomplete Brachial Plexus Injuries: A State-of-the-Art Review · 2026 · Related
  5. Unified Huntington's disease rating scale: Reliability and consistency · 1996 · 2097 citations · Cited by this paper
  6. Upper-Limb Cryoneurolysis for Painful Post-Stroke Spasticity in Severely Impaired Upper Limbs: A Feasibility Case Series · 2026 · Related
  7. Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival · Teruo Hayashi · 2007 · 1830 citations · Cited by this paper
  8. Utility and Wearability of the hitoe® Wearable ECG Monitoring System II for Detecting Covert Paroxysmal Atrial Fibrillation in Patients with Suspected ESUS Across Inpatient and Outpatient Settings: ACROSS-AF in ESUS · 2026 · Related
  9. Huntington's disease: from molecular pathogenesis to clinical treatment · Christopher A. Ross · 2010 · 1774 citations · Cited by this paper
  10. Impact of ABO Blood Group on Vascular Complications and on Clinical and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage · 2026 · Related
  11. Biomarkers for neurodegenerative diseases · Oskar Hansson · 2021 · 1179 citations · Cited by this paper
  12. Dynamic Changes in Endothelial Glycocalyx and Inflammatory Response in Patients with Acute Ischemic Stroke Treated with Mechanical Thrombectomy: Pathophysiological Aspects and Clinical Implications · 2026 · Related
  13. Amyotrophic lateral sclerosis · Eva L. Feldman · 2022 · 1131 citations · Cited by this paper
  14. Machine Learning Approaches to Early Detection of Parkinson’s Disease Using Speech Analysis Technique · 2026 · Related
  15. Targeting Huntingtin Expression in Patients with Huntington’s Disease · Sarah J. Tabrizi · 2019 · 723 citations · Cited by this paper
  16. Cadmium-Induced Toxicity as a Pathophysiological Mechanism for Parkinson’s Disease Onset in Individuals with Iron and Zinc Deficiencies and Chronic Obstructive Pulmonary Disease · 2026 · Related
  17. The pharmacology of sigma-1 receptors · Tangui Maurice · 2009 · 651 citations · Cited by this paper
  18. Therapeutic Advances in Major NBIA Disorders: Current Strategies and Translational Challenges · 2026 · Related
  19. Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data · Sarah J. Tabrizi · 2011 · 550 citations · Cited by this paper
  20. Huntington's disease clinical trials update: October 2025 · 2025 · Related
  21. A mutation in sigma‐1 receptor causes juvenile amyotrophic lateral sclerosis · Amr M. Al-Saif · 2011 · 432 citations · Cited by this paper
  22. Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis · Stephen A. Goutman · 2022 · 411 citations · Cited by this paper
  23. CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion · J.-H. Lee · 2012 · 398 citations · Cited by this paper
  24. Potential disease-modifying therapies for Huntington's disease: lessons learned and future opportunities · Sarah J. Tabrizi · 2022 · 340 citations · Cited by this paper
  25. A biological classification of Huntington's disease: the Integrated Staging System · Sarah J. Tabrizi · 2022 · 338 citations · Cited by this paper
  26. Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival · Tomohisa Mori · 2013 · 322 citations · Cited by this paper
  27. Lessons Learned from Alzheimer Disease: Clinical Trials with Negative Outcomes · Jeffrey L. Cummings · 2017 · 313 citations · Cited by this paper
  28. FTD and ALS: A Tale of Two Diseases · Raffaele Ferrari · 2011 · 280 citations · Cited by this paper
  29. Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study · Ton Fang · 2018 · 263 citations · Cited by this paper
  30. Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases · Daniel A. Ryskamp · 2019 · 224 citations · Cited by this paper
  31. Huntington’s disease: diagnosis and management · Thomas B. Stoker · 2021 · 204 citations · Cited by this paper
  32. Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration–motor neuron disease · Agnes A. Luty · 2010 · 196 citations · Cited by this paper
  33. The role of dopamine in huntington's disease · Carlos Cepeda · 2014 · 173 citations · Cited by this paper
  34. Pridopidine for the treatment of motor function in patients with Huntington's disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial · Justo García de Yébenes · 2011 · 173 citations · Cited by this paper
  35. Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities · Jordi Magrané · 2009 · 171 citations · Cited by this paper
  36. Sigma-1 Receptors Regulate Bcl-2 Expression by Reactive Oxygen Species-Dependent Transcriptional Regulation of Nuclear Factor κB · Johann Meunier · 2009 · 146 citations · Cited by this paper
  37. Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases · Tzu-Yu Weng · 2017 · 141 citations · Cited by this paper
  38. The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease · Daniel A. Ryskamp · 2016 · 132 citations · Cited by this paper
  39. A randomized, double‐blind, placebo‐controlled trial of pridopidine in Huntington's disease · The Huntington Study Group HART Investigators · 2013 · 127 citations · Cited by this paper

Source: OpenAlex (CC0)