Research map: HDAC6 inhibition alleviates dexamethasone-induced skeletal muscle atrophy and enhances UCP3-associated redox homeostasis

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  1. Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma · Loredana Santo · 2012 · 614 citations · Cited by this paper
  2. Nicotine drives lung cancer progression by suppressing cuproptosis through the LIAS–DLAT axis and promoting M2 macrophage polarization · 2026 · Related
  3. Mitochondrial dysfunction: roles in skeletal muscle atrophy · Xin Chen · 2023 · 313 citations · Cited by this paper
  4. Cyclophilin D (CypD) promotes mitochondrial impairment, synaptic defects, cognitive loss, and tau pathology during aging · 2026 · Related
  5. Ricolinostat plus lenalidomide, and dexamethasone in relapsed or refractory multiple myeloma: a multicentre phase 1b trial · Andrew Jenho Yee · 2016 · 207 citations · Cited by this paper
  6. Myeloid HIF-1α couples glycolytic energy supply with NCF2-dependent oxidative killing to protect against Klebsiella pneumoniae pneumonia · 2026 · Related
  7. Treating the Side Effects of Exogenous Glucocorticoids; Can We Separate the Good From the Bad ? · Riccardo Pofi · 2023 · 205 citations · Cited by this paper
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  9. The Role of Glucocorticoids in Inflammatory Diseases · Sybille D. Reichardt · 2021 · 168 citations · Cited by this paper
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  11. Metformin induces muscle atrophy by transcriptional regulation of myostatin via HDAC6 and FoxO3a · Min Ju Kang · 2021 · 104 citations · Cited by this paper
  12. Salvianolic acid B mitigates neuronal ferroptosis after intracerebral hemorrhage in rats through a Piezo1-associated AMPK–mTOR pathway · 2026 · Related
  13. Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target · Xinrong Zuo · 2025 · 76 citations · Cited by this paper
  14. Sucralose promotes cardiac redox-metabolic remodeling through MRPL12-associated mitoribosomal stress · 2026 · Related
  15. Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity · Işın Çakır · 2022 · 72 citations · Cited by this paper
  16. GPX3 downregulation in alveolar macrophages amplifies IL-17–dependent redox–inflammation crosstalk in ARDS · 2026 · Related
  17. Glucocorticoid-Mediated Skeletal Muscle Atrophy: Molecular Mechanisms and Potential Therapeutic Targets · Uttapol Permpoon · 2025 · 36 citations · Cited by this paper
  18. VBIT-4 attenuates diabetes-associated cardiovascular mitochondrial dysfunction and ROS production in a mouse model of diabetes and hyperlipidemic cellular assays · 2026 · Related
  19. Chemical Versatility in Catalysis and Inhibition of the Class IIb Histone Deacetylases · David W. Christianson · 2024 · 34 citations · Cited by this paper
  20. Loss of microglial ATM drives synaptic pruning and cognitive impairment in epilepsy · 2026 · Related
  21. Overexpression of UCP3 decreases mitochondrial efficiency in mouse skeletal muscle in vivo · Roberto Codella · 2022 · 28 citations · Cited by this paper
  22. Energy substrate metabolism, mitochondrial structure and oxidative stress after cardiac ischemia-reperfusion in mice lacking UCP3 · Patricia Sánchez-Pérez · 2023 · 24 citations · Cited by this paper
  23. Muscle-UCP3 in the regulation of energy metabolism · Lucio Della Guardia · 2024 · 21 citations · Cited by this paper
  24. Ginsenoside Rc prevents dexamethasone-induced muscle atrophy and enhances muscle strength and motor function · Aeyung Kim · 2024 · 20 citations · Cited by this paper
  25. Targeting Epigenetic Regulators with HDAC and BET Inhibitors to Modulate Muscle Wasting · Lorenzo Nevi · 2023 · 10 citations · Cited by this paper
  26. Histone deacetylase 6 inhibition promotes microtubule acetylation and facilitates autophagosome–lysosome fusion in dystrophin‐deficient mdx mice · Akanksha Agrawal · 2024 · 10 citations · Cited by this paper
  27. Lonafarnib Protects Against Muscle Atrophy Induced by Dexamethasone · Sanghoon Bae · 2024 · 7 citations · Cited by this paper
  28. Glucocorticoid-induced myopathy: a comprehensive review · Emilie Géfard-Gontier · 2025 · 6 citations · Cited by this paper
  29. Class I HDAC inhibitors attenuate dexamethasone-induced muscle atrophy via increased protein kinase C (PKC) delta phosphorylation · Justine S. Habibian · 2023 · 5 citations · Cited by this paper
  30. Transcriptional Co‐Activator With PDZ Binding Motif (TAZ) Inhibits Dexamethasone‐Induced Muscle Atrophy via mTOR Signalling · Kyung Min Kim · 2025 · 3 citations · Cited by this paper
  31. A Systematic Review and User Reference of Phenotypic and Molecular Characteristics of Dexamethasone‐Mediated C2C12 Muscle Atrophy · Alexa J. Klein · 2026 · 3 citations · Cited by this paper

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