Research map: Integrating single-cell and spheroid strategies in tissue engineering: Comparative insights from pancreas, cartilage, heart and brain

Back to the article

Papers in this map

  1. Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association · William J. Powers · 2019 · 7590 citations · Cited by this paper
  2. From niche to organoid: Engineering bone tissues through microenvironmental insights · 2025 · Related
  3. The Basic Science of Articular Cartilage: Structure, Composition, and Function · Alice J. S. Fox · 2009 · 2826 citations · Cited by this paper
  4. Cardiac fibroblast-mediated ECM remodeling regulates maturation in an in vitro 3D engineered cardiac tissue · 2025 · Related
  5. World Stroke Organization: Global Stroke Fact Sheet 2025 · Valery L. Feigin · 2024 · 1360 citations · Cited by this paper
  6. Human three-dimensional engineered muscle tissue characterization and intramyocellular lipid modeling · 2025 · Related
  7. Unlike Bone, Cartilage Regeneration Remains Elusive · Daniel J. Huey · 2012 · 1206 citations · Cited by this paper
  8. Safety and efficacy of bio-engineered, autologous dermo-epidermal skin grafts in reconstructive surgery: 1-year results of a prospective, randomized, intra-patient controlled, multicenter phase II clinical trial · 2026 · Related
  9. Spheroid culture as a tool for creating 3D complex tissues · Eelco M. Fennema · 2013 · 1071 citations · Cited by this paper
  10. In vitro models of muscle spindles: From traditional methods to 3D bioprinting strategies · 2025 · Related
  11. Pancreatic regulation of glucose homeostasis · Pia V. Röder · 2016 · 996 citations · Cited by this paper
  12. Stage-specific cardiotoxicity induced by bisphenol A using human pluripotent stem cell-derived 2D- and 3D-cardiomyocyte models · 2025 · Related
  13. Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration · Virpi Talman · 2016 · 931 citations · Cited by this paper
  14. Hair regeneration: Mechano-activation and related therapeutic approaches · 2025 · Related
  15. Biofabrication strategies for 3D in vitro models and regenerative medicine · Lorenzo Moroni · 2018 · 764 citations · Cited by this paper
  16. Microfluidic organ-on-a-chip for modeling coronary artery disease: Recent applications, limitations and potential · 2025 · Related
  17. Human embryonic stem cell–derived cardiomyocytes restore function in infarcted hearts of non-human primates · Yen-Wen Liu · 2018 · 641 citations · Cited by this paper
  18. Genetically modified bone marrow cells halt mitral cell loss by modulating inflammation and protecting against DNA damage · 2026 · Related
  19. Maturation of Human Embryonic Stem Cell–Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice · Alireza Rezania · 2012 · 606 citations · Cited by this paper
  20. Enhanced cell sheet engineering through combination of single cells and spheroids on liquid interface using perfluorocarbon · 2025 · Related
  21. Role of Insulin in Health and Disease: An Update · Md Saidur Rahman · 2021 · 471 citations · Cited by this paper
  22. Engineering Stem Cell Self-organization to Build Better Organoids · Jonathan A. Brassard · 2019 · 380 citations · Cited by this paper
  23. Matrix-Applied Characterized Autologous Cultured Chondrocytes Versus Microfracture: Five-Year Follow-up of a Prospective Randomized Trial · Mats Brittberg · 2018 · 298 citations · Cited by this paper
  24. Teplizumab and β-Cell Function in Newly Diagnosed Type 1 Diabetes · Eleanor L. Ramos · 2023 · 259 citations · Cited by this paper
  25. Autologous Chondrocyte Implantation Using a Bilayer Collagen Membrane: A Preliminary Report · Paolo Cherubino · 2003 · 253 citations · Cited by this paper
  26. Engineering Multi‐Cellular Spheroids for Tissue Engineering and Regenerative Medicine · Se‐Jeong Kim · 2020 · 242 citations · Cited by this paper
  27. Cell-Seeding Techniques in Vascular Tissue Engineering · Gustavo Adolfo Villalona · 2010 · 222 citations · Cited by this paper
  28. Biomaterials for Tissue Engineering Applications and Current Updates in the Field: A Comprehensive Review · Alaa Emad Eldeeb · 2022 · 167 citations · Cited by this paper
  29. Vascularization in tissue engineering: fundamentals and state-of-art · Guang Yang · 2019 · 158 citations · Cited by this paper
  30. Engineered heart muscle allografts for heart repair in primates and humans · Ahmad-Fawad Jebran · 2025 · 150 citations · Cited by this paper
  31. Structural and functional integration of human forebrain organoids with the injured adult rat visual system · Dennis Jgamadze · 2023 · 134 citations · Cited by this paper
  32. Engineering islets from stem cells for advanced therapies of diabetes · Johanna Siehler · 2021 · 130 citations · Cited by this paper
  33. Engineered biomaterials to guide spheroid formation, function, and fabrication into 3D tissue constructs · Nikolas Di Caprio · 2022 · 124 citations · Cited by this paper
  34. Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals · Shinji Kawaguchi · 2021 · 107 citations · Cited by this paper
  35. Cartilage repair in the degenerative ageing knee · Mats Brittberg · 2016 · 98 citations · Cited by this paper
  36. A Glycosaminoglycan Based, Modular Tissue Scaffold System for Rapid Assembly of Perfusable, High Cell Density, Engineered Tissues · Ramkumar T. Annamalai · 2014 · 92 citations · Cited by this paper
  37. A Prospective, Randomized, Open-Label, Multicenter, Phase III Noninferiority Trial to Compare the Clinical Efficacy of Matrix-Associated Autologous Chondrocyte Implantation With Spheroid Technology Versus Arthroscopic Microfracture for Cartilage Defects of the Knee · Philipp Niemeyer · 2019 · 91 citations · Cited by this paper
  38. Heart Transplantation: Challenges Facing the Field · Makoto Tonsho · 2014 · 90 citations · Cited by this paper
  39. Assessment of Native Human Articular Cartilage: A Biomechanical Protocol · Wassif Kabir · 2020 · 88 citations · Cited by this paper

Source: OpenAlex (CC0)