Research map: Revisiting Diffuse Gliomas in the Era of Precision Medicine: Molecular Insights and Therapeutic Implications

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  1. Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma · Roger Stupp · 2005 · 22129 citations · Cited by this paper
  2. TROP-2 in solid tumors: From oncogenic driver to therapeutic target with antibody-drug conjugates · 2026 · Related
  3. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary · David N. Louis · 2016 · 16167 citations · Cited by this paper
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  5. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary · David N. Louis · 2021 · 12624 citations · Cited by this paper
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  7. IDH1 and IDH2 Mutations in Gliomas · Hai Yan · 2009 · 6011 citations · Cited by this paper
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  11. EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood · Michael Weller · 2020 · 2073 citations · Cited by this paper
  12. Remodeling the immune microenvironment: Engineering IL-2 variants to overcome clinical bottlenecks in PD-1 inhibitor plus chemotherapy · 2026 · Related
  13. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2016—2020 · Quinn T. Ostrom · 2023 · 1309 citations · Cited by this paper
  14. Extracellular vesicle-mediated immunity-coagulation interaction in cancer-associated thrombosis during the immunotherapy era · 2026 · Related
  15. Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma · Ingo K. Mellinghoff · 2023 · 808 citations · Cited by this paper
  16. Liquid biopsy for early cancer detection in hereditary cancer syndromes: Current evidence · 2026 · Related
  17. Adjuvant Procarbazine, Lomustine, and Vincristine Improves Progression-Free Survival but Not Overall Survival in Newly Diagnosed Anaplastic Oligodendrogliomas and Oligoastrocytomas: A Randomized European Organisation for Research and Treatment of Cancer Phase III Trial · Martin J. van den Bent · 2006 · 750 citations · Cited by this paper
  18. Current status and prospects of chemotherapy-free strategies in ovarian cancer · 2026 · Related
  19. Advances in the molecular genetics of gliomas — implications for classification and therapy · Guido Reifenberger · 2016 · 696 citations · Cited by this paper
  20. cIMPACT ‐ NOW update 11: Proposal on adaptation of diagnostic criteria for IDH ‐ and H3 ‐wildtype diffuse high‐grade gliomas and for posterior fossa ependymal tumors · 2025 · Related
  21. IDH mutation in glioma: molecular mechanisms and potential therapeutic targets · Sue Han · 2020 · 669 citations · Cited by this paper
  22. Glioma · Michael Weller · 2024 · 580 citations · Cited by this paper
  23. Overcoming therapeutic resistance in glioblastoma: the way forward · Satoru Osuka · 2017 · 545 citations · Cited by this paper
  24. Benefit From Procarbazine, Lomustine, and Vincristine in Oligodendroglial Tumors Is Associated With Mutation of IDH · John Gregory Cairncross · 2014 · 405 citations · Cited by this paper
  25. Mechanisms of Resistance and Current Treatment Options for Glioblastoma Multiforme (GBM) · Satya Siva Kishan Yalamarty · 2023 · 296 citations · Cited by this paper
  26. Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response · Kevin C. Johnson · 2021 · 286 citations · Cited by this paper
  27. Blood-brain barrier–penetrating single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy · Yan Zou · 2022 · 220 citations · Cited by this paper
  28. Artificial-intelligence-based molecular classification of diffuse gliomas using rapid, label-free optical imaging · Todd Charles Hollon · 2023 · 186 citations · Cited by this paper
  29. DNA damage response inhibitors in cancer therapy: lessons from the past, current status and future implications · Yvette Drew · 2024 · 175 citations · Cited by this paper
  30. MR-guided focused ultrasound liquid biopsy enriches circulating biomarkers in patients with brain tumors · Ying Meng · 2021 · 170 citations · Cited by this paper
  31. Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma · Erik Jung · 2021 · 163 citations · Cited by this paper
  32. A transformer-based weakly supervised computational pathology method for clinical-grade diagnosis and molecular marker discovery of gliomas · Rui Jiang · 2024 · 141 citations · Cited by this paper
  33. Circulating tumor cell is a common property of brain glioma and promotes the monitoring system · Faliang Gao · 2016 · 134 citations · Cited by this paper
  34. Repeated blood–brain barrier opening with a nine-emitter implantable ultrasound device in combination with carboplatin in recurrent glioblastoma: a phase I/II clinical trial · Alexandre C. Carpentier · 2024 · 132 citations · Cited by this paper
  35. Management of diffuse low-grade gliomas in adults — use of molecular diagnostics · Jan C. Buckner · 2017 · 130 citations · Cited by this paper
  36. Targeted next-generation sequencing panel (GlioSeq) provides comprehensive genetic profiling of central nervous system tumors · Marina N. Nikiforova · 2015 · 121 citations · Cited by this paper
  37. The tumour microenvironment, treatment resistance and recurrence in glioblastoma · Jasmine White · 2024 · 119 citations · Cited by this paper
  38. DNMT-dependent suppression of microRNA regulates the induction of GBM tumor-propagating phenotype by Oct4 and Sox2 · Hernando López-Bertoni · 2014 · 116 citations · Cited by this paper
  39. EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection · David Capper · 2023 · 111 citations · Cited by this paper

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