Research map: Si-Miao-Yong-An Decoction: From traditional efficacy to pharmacological mechanisms and modern therapeutic applications

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  1. The changing landscape of atherosclerosis · Peter Libby · 2021 · 2895 citations · Cited by this paper
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  13. Altered Myocardial Substrate Metabolism and Decreased Diastolic Function in Nonischemic Human Diabetic Cardiomyopathy · Luuk J. Rijzewijk · 2009 · 314 citations · Cited by this paper
  14. Quercetin, kaempferol, baicalein, and ellagic acid in Guizhi Fuling Wan suppress Glioblastoma by inducing p21-mediated cell cycle arrest and mitochondrial apoptosis · 2026 · Related
  15. Bacteriotherapy with Lactobacillus plantarum in burns · M.C. Peral · 2009 · 195 citations · Cited by this paper
  16. Mechanistic pharmacology of TCM-derived bioactive compounds in Alzheimer’s disease: molecular targets, standardization, and translational insights · 2026 · Related
  17. Main active components of Si-Miao-Yong-An decoction (SMYAD) attenuate autophagy and apoptosis via the PDE5A-AKT and TLR4-NOX4 pathways in isoproterenol (ISO)-induced heart failure models · Minru Liao · 2022 · 105 citations · Cited by this paper
  18. Unraveling Nature's Hidden Secret: Exploring the Botanical Therapeutics and Multifunctional Pharmacological Potentials of Snake Melon (Cucumis melo var. flexuosus) · 2026 · Related
  19. Phosphoinositide 3-Kinase γ Gene Knockout Impairs Postischemic Neovascularization and Endothelial Progenitor Cell Functions · Paolo Roberto Madeddu · 2007 · 81 citations · Cited by this paper
  20. From Qi to synapse: A systems-based review of Traditional Chinese Medicine in the treatment of major depressive disorder · 2026 · Related
  21. Frequency-Dependent Phenotype Modulation of Vascular Smooth Muscle Cells under Cyclic Mechanical Strain · Mingjuan Qu · 2007 · 74 citations · Cited by this paper
  22. Si-Miao-Yong-An decoction ameliorates cardiac function through restoring the equilibrium of SOD and NOX2 in heart failure mice · Yinglu Ren · 2019 · 67 citations · Cited by this paper
  23. The anti-hyperuricemic effect of four astilbin stereoisomers in Smilax glabra on hyperuricemic mice · Liping Huang · 2019 · 64 citations · Cited by this paper
  24. Effect of Si-Miao-Yong-An on the stability of atherosclerotic plaque in a diet-induced rabbit model · Li Peng · 2012 · 42 citations · Cited by this paper
  25. Natural Products as a Source of Inspiration for Novel Inhibitors of Advanced Glycation Endproducts (AGEs) Formation · Stefaniya Velichkova · 2021 · 42 citations · Cited by this paper
  26. Dissection of mechanisms of Chinese medicinal formula Si-Miao-Yong-an decoction protects against cardiac hypertrophy and fibrosis in isoprenaline-induced heart failure · Yuqian Zhao · 2019 · 40 citations · Cited by this paper
  27. Protective effect of a Chinese Medicine formula He-Ying-Qing-Re Formula on diabetic retinopathy · Leilei Wang · 2015 · 39 citations · Cited by this paper
  28. Si-Miao-Yong-An decoction preserves cardiac function and regulates GLC/AMPK/NF-κB and GLC/PPARα/PGC-1α pathways in diabetic mice · Lin Li · 2020 · 39 citations · Cited by this paper
  29. Promotion of classic neutral bile acids synthesis pathway is responsible for cholesterol-lowing effect of Si-miao-yong-an decoction: Application of LC–MS/MS method to determine 6 major bile acids in rat liver and plasma · Ziying Liu · 2016 · 37 citations · Cited by this paper
  30. Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-β1 pathway and interfering with MMP-TIMPs expression · Congping Su · 2020 · 35 citations · Cited by this paper
  31. An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response · Mustafa Can Güler · 2023 · 32 citations · Cited by this paper
  32. Deciphering the effective combinatorial components from Si-Miao-Yong-An decoction regarding the intervention on myocardial hypertrophy · Xiangyang Chen · 2021 · 31 citations · Cited by this paper
  33. Si-Miao-Yong-An Decoction for Diabetic Retinopathy: A Combined Network Pharmacological and In Vivo Approach · Ao Du · 2021 · 29 citations · Cited by this paper
  34. Si-Miao-Yong-An Decoction attenuates isoprenaline-induced myocardial fibrosis in AMPK-driven Akt/mTOR and TGF-β/SMAD3 pathways · Yuqian Zhao · 2020 · 27 citations · Cited by this paper
  35. Auto-Antibody Production During Experimental Atherosclerosis in ApoE-/- Mice · Mark A. Hutchinson · 2021 · 26 citations · Cited by this paper
  36. Network pharmacology-based approach to research the effect and mechanism of Si-Miao-Yong-An decoction against thromboangiitis obliterans · Jiaxi Zou · 2023 · 25 citations · Cited by this paper
  37. Si-Miao-Yong-An on promoting the maturation of Vasa Vasorum and stabilizing atherosclerotic plaque in ApoE-/- mice： An experimental study · Zhongwen Qi · 2019 · 23 citations · Cited by this paper
  38. Effect of Si-Miao-Yong-An decoction on the differentiation of monocytes, macrophages, and regulatory T cells in ApoE−/− mice · Xin-Nong Chen · 2021 · 23 citations · Cited by this paper
  39. Piezo1 senses pressure overload and initiates cardiac hypertrophy · Gregory B. Lim · 2022 · 20 citations · Cited by this paper

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