Research map: Ethics of gene therapy

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Papers in this map

  1. A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity · Martin Jínek · 2012 · 17808 citations · Cited by this paper
  2. A single-cell solution to a transplant mystery · 2026 · Related
  3. The new frontier of genome engineering with CRISPR-Cas9 · Jennifer A. Doudna · 2014 · 7202 citations · Cited by this paper
  4. Five trials reshaping multiple myeloma · 2026 · Related
  5. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage · Alexis C. Komor · 2016 · 5685 citations · Cited by this paper
  6. Loss of tumor suppressor NF2 mediates resistance to CAR T cell and anti-PD-1 therapy: Strategies to restore immunotherapy sensitivity · 2026 · Related
  7. Search-and-replace genome editing without double-strand breaks or donor DNA · Andrew V. Anzalone · 2019 · 4941 citations · Cited by this paper
  8. Advanced cholangiocarcinoma in 2025: Therapeutic sequencing and global implementation · 2026 · Related
  9. LMO2 -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1 · S. Hacein-Bey-Abina · 2003 · 3601 citations · Cited by this paper
  10. Resectability redefined: Lessons from quadruple therapy in HCC · 2026 · Related
  11. Adeno-associated virus vector as a platform for gene therapy delivery · Dan Wang · 2019 · 2488 citations · Cited by this paper
  12. Rethinking parenteral nutrition as supportive therapy for neonatal sepsis · 2026 · Related
  13. Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy · Jerry R. Mendell · 2017 · 2426 citations · Cited by this paper
  14. Rewriting the sarcomere: Gene therapy approaches for hypertrophic cardiomyopathy from bench to bedside · 2026 · Related
  15. The personal and clinical utility of polygenic risk scores · Ali Torkamani · 2018 · 1795 citations · Cited by this paper
  16. Power and sample-size estimation in human microbiome research · 2026 · Related
  17. Health as a Theoretical Concept · Christopher Boorse · 1977 · 1776 citations · Cited by this paper
  18. Building on CD19 based therapy for relapse or refractory follicular lymphoma · 2026 · Related
  19. Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients · Steven J. Howe · 2008 · 1300 citations · Cited by this paper
  20. Impact of lead-in ADT on grade ≥3 neutropenia in patients with metastatic hormone-sensitive prostate cancer treated with triplet therapy · 2026 · Related
  21. Procreative Beneficence: Why We Should Select the Best Children · Julian Savulescu · 2001 · 870 citations · Cited by this paper
  22. The new genetics of intelligence · Robert J. Plomin · 2018 · 534 citations · Cited by this paper
  23. Don’t edit the human germ line · Edward H. Lanphier · 2015 · 514 citations · Cited by this paper
  24. CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury · Mary Teena Joy · 2019 · 393 citations · Cited by this paper
  25. Lessons learned from the gene therapy trial for ornithine transcarbamylase deficiency · James M. Wilson · 2009 · 303 citations · Cited by this paper
  26. Genetic Dilemmas and the Child's Right to an Open Future · Dena S. Davis · 1997 · 295 citations · Cited by this paper
  27. A brief history of gene therapy · Theodore Friedmann · 1992 · 275 citations · Cited by this paper
  28. Frequent loss of heterozygosity in CRISPR-Cas9–edited early human embryos · Gregorio Alanis‐Lobato · 2021 · 231 citations · Cited by this paper
  29. CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations · Ida Höijer · 2022 · 196 citations · Cited by this paper
  30. The Ethics of Germline Gene Editing · Christopher Gyngell · 2016 · 171 citations · Cited by this paper
  31. The CRISPR-baby scandal: what’s next for human gene-editing · David Cyranoski · 2019 · 147 citations · Cited by this paper
  32. Broad consent for biobanks is best – provided it is also deep · Rasmus Bjerregaard Mikkelsen · 2019 · 145 citations · Cited by this paper
  33. New breeds of humans: the moral obligation to enhance · Julian Savulescu · 2005 · 143 citations · Cited by this paper
  34. Enhancing RNA-lipid nanoparticle delivery: Organ- and cell-specificity and barcoding strategies · Pu-Sheng Wei · 2024 · 129 citations · Cited by this paper
  35. Screening Human Embryos for Polygenic Traits Has Limited Utility · Ehud Karavani · 2019 · 123 citations · Cited by this paper
  36. Therapeutic misconception in early phase gene transfer trials · Gail E. Henderson · 2005 · 120 citations · Cited by this paper
  37. Harm, ethics committees and the gene therapy death · Julian Savulescu · 2001 · 113 citations · Cited by this paper
  38. Choosing Who Will Be Disabled: Genetic Intervention and the Morality of Inclusion · Allen E. Buchanan · 1996 · 112 citations · Cited by this paper
  39. Gene therapy: evidence, value and affordability in the US health care system · Grace Hampson · 2017 · 106 citations · Cited by this paper

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