Research map: Extracellular vesicles and their translational therapeutic potential

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Papers in this map

  1. Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches · Joshua A Welsh · 2024 · 4417 citations · Cited by this paper
  2. Schiff base metal complexes as emerging therapeutics against antimicrobial-resistant skin pathogens · 2026 · Related
  3. PRISMA2020 : An R package and Shiny app for producing PRISMA 2020‐compliant flow diagrams, with interactivity for optimised digital transparency and Open Synthesis · Neal Haddaway · 2022 · 3434 citations · Cited by this paper
  4. Rosanoid diterpenoids: structural diversity, classification and biological activities · 2026 · Related
  5. Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021 · Jaimie D Steinmetz · 2023 · 2016 citations · Cited by this paper
  6. Development of a biorelevant dissolution method for inhalation products: Proof of concept using drugs with diverse solubilities · 2025 · Related
  7. Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model · Shi‐Cong Tao · 2016 · 752 citations · Cited by this paper
  8. Neuroprotective cellular and molecular mechanisms of physical exercise on neurodegenerative diseases · 2026 · Related
  9. miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis · Jiangyi Wu · 2019 · 605 citations · Cited by this paper
  10. Structure-activity relationship of captopril derivatives as New Delhi metallo beta-lactamase 1 inhibitors · 2026 · Related
  11. Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis · Yu Zhu · 2017 · 480 citations · Cited by this paper
  12. Elucidating CYP2D6-driven metabolism and hepatotoxic bioactivation of metoprolol in plateable human and animal hepatocytes · 2025 · Related
  13. Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis · Lei He · 2020 · 459 citations · Cited by this paper
  14. Novel stirring method for small-scale dissolution test: Rotating vessel method · 2026 · Related
  15. Exosome-mediated delivery of kartogenin for chondrogenesis of synovial fluid-derived mesenchymal stem cells and cartilage regeneration · Xiao Gang Xu · 2020 · 380 citations · Cited by this paper
  16. Design, synthesis and antitubercular evaluation of novel 5,6-diphenyl-1,2,4-triazine-piperazine derivatives targeting mycobacterial dihydrofolate reductase · 2026 · Related
  17. Small extracellular vesicles from human adipose‐derived stem cells attenuate cartilage degeneration · Chang Hee Woo · 2020 · 309 citations · Cited by this paper
  18. Engineered Extracellular Vesicles in Arthritic Diseases: Therapeutic Applications & Challenges · 2025 · Related
  19. Anti-inflammatory and immunomodulatory effects of the extracellular vesicles derived from human umbilical cord mesenchymal stem cells on osteoarthritis via M2 macrophages · Kanglu Li · 2022 · 251 citations · Cited by this paper
  20. Exosomes from the synovial microenvironment in joint homeostasis and osteoarthritis · 2024 · Related
  21. Bone marrow mesenchymal stem cell-derived exosomes prevent osteoarthritis by regulating synovial macrophage polarization · Jiyong Zhang · 2020 · 210 citations · Cited by this paper
  22. Extracellular vesicles from adipose tissue‐derived stem cells alleviate osteoporosis through osteoprotegerin and miR‐21‐5p · Kyoung Soo Lee · 2021 · 204 citations · Cited by this paper
  23. Cell-Free Osteoarthritis Treatment with Sustained-Release of Chondrocyte-Targeting Exosomes from Umbilical Cord-Derived Mesenchymal Stem Cells to Rejuvenate Aging Chondrocytes · Hongfu Cao · 2023 · 170 citations · Cited by this paper
  24. Therapeutic effects of bone marrow mesenchymal stem cells‐derived exosomes on osteoarthritis · Yi Jin · 2021 · 163 citations · Cited by this paper
  25. Exosomes Derived From Human Urine–Derived Stem Cells Overexpressing miR-140-5p Alleviate Knee Osteoarthritis Through Downregulation of VEGFA in a Rat Model · Yuan Liu · 2022 · 134 citations · Cited by this paper
  26. Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success · Griffin Copp · 2023 · 132 citations · Cited by this paper
  27. Exosomes from adipose‑derived stem cells promote chondrogenesis and suppress inflammation by upregulating miR‑145 and miR‑221 · Chen Zhao · 2020 · 120 citations · Cited by this paper
  28. Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis · Shu Zhao · 2023 · 113 citations · Cited by this paper
  29. BMSCs‐Derived Exosomes Ameliorate Pain Via Abrogation of Aberrant Nerve Invasion in Subchondral Bone in Lumbar Facet Joint Osteoarthritis · Jinsong Li · 2019 · 103 citations · Cited by this paper
  30. Knee osteoarthritis: disease burden, available treatments, and emerging options · Michael J. Langworthy · 2024 · 102 citations · Cited by this paper
  31. Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model · Ao Duan · 2021 · 82 citations · Cited by this paper
  32. Exosomes derived from umbilical cord mesenchymal stem cells in mechanical environment show improved osteochondral activity via upregulation of LncRNA H19 · Litao Yan · 2020 · 81 citations · Cited by this paper
  33. Comparison of Curative Effect of Human Umbilical Cord-Derived Mesenchymal Stem Cells and Their Small Extracellular Vesicles in Treating Osteoarthritis · Shijie Tang · 2021 · 75 citations · Cited by this paper
  34. Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritis · Aliosha I. Figueroa‐Valdés · 2025 · 70 citations · Cited by this paper
  35. Synovial Mesenchymal Stem Cell-Derived EV-Packaged miR-31 Downregulates Histone Demethylase KDM2A to Prevent Knee Osteoarthritis · Kunpeng Wang · 2020 · 69 citations · Cited by this paper
  36. Effects of human umbilical cord mesenchymal stem cell-derived exosomes in the rat osteoarthritis models · Huanfeng Yang · 2024 · 57 citations · Cited by this paper
  37. Exosomes derived from umbilical cord mesenchymal stem cells protect cartilage and regulate the polarization of macrophages in osteoarthritis · Pengdong Li · 2022 · 56 citations · Cited by this paper
  38. Bone marrow mesenchymal stem cell exosome-derived lncRNA TUC339 influences the progression of osteoarthritis by regulating synovial macrophage polarization and chondrocyte apoptosis · Xun Shen · 2023 · 55 citations · Cited by this paper
  39. A Comparative Study on the Effect of Exosomes Secreted by Mesenchymal Stem Cells Derived from Adipose and Bone Marrow Tissues in the Treatment of Osteoarthritis‐Induced Mouse Model · Hoda Fazaeli · 2021 · 54 citations · Cited by this paper

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