Research map: Neuroinflammation in Alzheimer’s and Parkinson’s diseases: pathogenic mechanisms and therapeutic strategies

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Papers in this map

  1. Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors · Kazutoshi Takahashi · 2006 · 26993 citations · Cited by this paper
  2. The neuroimmune axis of Alzheimer’s disease · Mehdi Jorfi · 2023 · 300 citations · Related
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  4. Application of the Allen Human Brain Atlas in Alzheimer’s disease and Parkinson’s disease · 2026 · Related
  5. Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo · Axel Nimmerjahn · 2005 · 5988 citations · Cited by this paper
  6. Age-dependent removal of Atg9-containing vesicle accumulations in motoneuron disease models by physical exercise · 2025 · Related
  7. A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease · Hadas Keren‐Shaul · 2017 · 5894 citations · Cited by this paper
  8. Reduced synaptic vesicle protein 2A in extracellular vesicles and brains of Alzheimer’s disease: associations with Aβ, tau, synaptic proteins and APOE ε4 · 2025 · Related
  9. Lecanemab in Early Alzheimer’s Disease · Christopher H. van Dyck · 2022 · 5709 citations · Cited by this paper
  10. Targeting the glymphatic system: Aβ accumulation and phototherapy strategies across different stages of Alzheimer’s disease · 2025 · Related
  11. Parkinson disease · Werner H Poewe · 2017 · 5208 citations · Cited by this paper
  12. Attenuating α-synuclein pathology in mice with in situ engineered astrocytes · 2025 · Related
  13. IL-17 and Th17 Cells · Thomas Korn · 2009 · 4893 citations · Cited by this paper
  14. Stratification of brain-derived extracellular vesicles of Alzheimer’s disease patients indicates a unique proteomic content and a higher seeding capacity of small extracellular vesicles · 2025 · Related
  15. The NLRP3 inflammasome: molecular activation and regulation to therapeutics · Karen V. Swanson · 2019 · 4883 citations · Cited by this paper
  16. LRRK2 G2019S mutation contributes to mitochondrial transfer dysfunction in a Drp1-STX17-dependent manner · 2025 · Related
  17. Mechanisms Underlying Inflammation in Neurodegeneration · Christopher K. Glass · 2010 · 3599 citations · Cited by this paper
  18. Dynamic Involvement of Striatal NG2-glia in L-DOPA Induced Dyskinesia in Parkinsonian Rats: Effects of Doxycycline · 2023 · Related
  19. Complement and microglia mediate early synapse loss in Alzheimer mouse models · Soyon Hong · 2016 · 3522 citations · Cited by this paper
  20. Immunization targeting diseased proteins in synucleinopathy and tauopathy: insights from clinical trials · 2025 · Related
  21. Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? · Fangda Leng · 2020 · 3295 citations · Cited by this paper
  22. 2023 Alzheimer's disease facts and figures · 2023 · 3258 citations · Cited by this paper
  23. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases · Susanne Krasemann · 2017 · 3194 citations · Cited by this paper
  24. The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease · Jeff Sevigny · 2016 · 3132 citations · Cited by this paper
  25. Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains · Patrick L. McGeer · 1988 · 3041 citations · Cited by this paper
  26. Microglia Function in the Central Nervous System During Health and Neurodegeneration · Marco Colonna · 2017 · 2966 citations · Cited by this paper
  27. NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice · Michael Thomas Heneka · 2012 · 2962 citations · Cited by this paper
  28. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators · Charles Nicholas Serhan · 2008 · 2947 citations · Cited by this paper
  29. Recognition of microorganisms and activation of the immune response · Ruslan M. Medzhitov · 2007 · 2875 citations · Cited by this paper
  30. Single-cell transcriptomic analysis of Alzheimer’s disease · Hansruedi Mathys · 2019 · 2845 citations · Cited by this paper
  31. Identification of a unique TGF-β–dependent molecular and functional signature in microglia · Oleg Butovsky · 2013 · 2725 citations · Cited by this paper
  32. The projected effect of risk factor reduction on Alzheimer's disease prevalence · Deborah E. Barnes · 2011 · 2710 citations · Cited by this paper
  33. Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse · Ye Zhang · 2015 · 2540 citations · Cited by this paper
  34. Reactive astrocyte nomenclature, definitions, and future directions · Carole Escartin · 2021 · 2514 citations · Cited by this paper
  35. The cGAS–STING pathway as a therapeutic target in inflammatory diseases · Alexiane C. Decout · 2021 · 2342 citations · Cited by this paper
  36. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration · Liya Qin · 2007 · 2193 citations · Cited by this paper
  37. Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease · E. Sidransky · 2009 · 2182 citations · Cited by this paper
  38. Sphingosine-1-phosphate: an enigmatic signalling lipid · Sarah Spiegel · 2003 · 2089 citations · Cited by this paper
  39. Microglia states and nomenclature: A field at its crossroads · Rosa Chiara Paolicelli · 2022 · 2058 citations · Cited by this paper

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