Research map: Predicting pHmax and Salt DisproportionationRisk for Basic Drugs

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  1. Polymorphism in Molecular Solids: An Extraordinary System of Red, Orange, and Yellow Crystals · Lian Yu · 2010 · 358 citations · Cited by this paper
  2. A CosmeticProduct Containing PEG Derivatives InducesAnti-PEG IgM Mainly through Stimulation of the Spleen Cells in Mice · 2026 · Related
  3. Physical Stability of Salts of Weak Bases in the Solid-State · Gregory A. Stephenson · 2010 · 160 citations · Cited by this paper
  4. [68Ga]Ga-DOTA-DP-UBI 29-41: A Novel 68Ga-LabeledUbiquicidin 29-41 Derivative Containing d -Prolinefor Bacterial Infection PET Imaging · 2026 · Related
  5. Recent developments in pharmaceutical salts: FDA approvals from 2015 to 2019 · Sonali S. Bharate · 2020 · 150 citations · Cited by this paper
  6. PreclinicalEvaluation of 177Lu-LabeledAnti-CLDN18.2 VHH-Fc for Radioimmunotherapy in Gastric Cancer · 2026 · Related
  7. Bioavailability enhancement of a poorly water-soluble drug by solid dispersion in polyethylene glycol–polysorbate 80 mixture · Hemant Joshi · 2003 · 148 citations · Cited by this paper
  8. Development of [111In]In-CHX-A″-DTPA-αCD68for ImmunoSPECT to Image Murine Macrophages · 2026 · Related
  9. Solubility of Organic Hydrochlorides · Sherman F. Kramer · 1972 · 133 citations · Cited by this paper
  10. Design, Synthesis, and Preclinical Evaluation of Novel Dimeric RM2-Based Radioligands for GRPR-Targeted Breast Cancer Imaging · 2026 · Related
  11. In Situ Salt Screening-A Useful Technique for Discovery Support and Preformulation Studies · Wei‐Qin Tong · 1998 · 124 citations · Cited by this paper
  12. IntegratingTumor Targeting and Half-Life Extensioninto a Dual-Surfaced Single-Domain ADAPT Protein · 2026 · Related
  13. Balancing Solid-State Stability and Dissolution Performance of Lumefantrine Amorphous Solid Dispersions: The Role of Polymer Choice and Drug–Polymer Interactions · Tze Ning Hiew · 2021 · 119 citations · Cited by this paper
  14. Tuningthe Structural Properties of a Single-DomainAntibody Scaffold for Improved Fibroblast Activation Protein Targeting · 2026 · Related
  15. Solubility of Doxycycline in Aqueous Solution · Joseph B. Bogardus · 1979 · 109 citations · Cited by this paper
  16. AutomatedRadiosynthesis of High-Molar-Activity 4-Borono-2-[18F]Fluorophenylalanine: Validation in Rodent Tumor Modelsand Nonhuman Primates · 2026 · Related
  17. Role of Salt and Excipient Properties on Disproportionation in the Solid-State · Peter Guerrieri · 2009 · 106 citations · Cited by this paper
  18. Evaluationof 161Tb-Labeled DOTA-Ibandronatefor Targeted Radionuclide Therapy in Bone Metastases · 2026 · Related
  19. General Treatment of pH-Solubility Profiles of Weak Acids and Bases and the Effects of Different Acids on the Solubility of a Weak Base · William H. Streng · 1984 · 87 citations · Cited by this paper
  20. PreclinicalEvaluation of [68Ga]Ga-CS03as a Novel GPC3-Targeted Probe for Imaging GPC3 in HepatocellularCarcinoma Models · 2026 · Related
  21. Solubility of Pharmaceuticals and Their Salts As a Function of pH · Jan Cassens · 2013 · 82 citations · Cited by this paper
  22. Effects of surface active characteristics and solid state forms on the pH solubility profiles of drug–salt systems · Mark T. Ledwidge · 1998 · 76 citations · Cited by this paper
  23. Effect of Chloride ion on Dissolution of Different Salt Forms of Haloperidol, a Model Basic Drug · Shoufeng Li · 2005 · 73 citations · Cited by this paper
  24. Implementing Quality by Design in Pharmaceutical Salt Selection: A Modeling Approach to Understanding Disproportionation · Jeremy M. Merritt · 2012 · 70 citations · Cited by this paper
  25. Salt Stability – The Effect of pHmax on Salt to Free Base Conversion · Yi‐Ling Hsieh · 2015 · 58 citations · Cited by this paper
  26. Formulating Weakly Basic HCl Salts: Relative Ability of Common Excipients to Induce Disproportionation and the Unique Deleterious Effects of Magnesium Stearate · Christopher T. John · 2013 · 57 citations · Cited by this paper
  27. Impact of Counterion on the Chemical Stability of Crystalline Salts of Procaine · Peter Guerrieri · 2009 · 55 citations · Cited by this paper
  28. The Influence of the Strength of Drug–Polymer Interactions on the Dissolution of Amorphous Solid Dispersions · Kweku K. Amponsah-Efah · 2020 · 53 citations · Cited by this paper
  29. Continuous Preparation of 1:1 Haloperidol–Maleic Acid Salt by a Novel Solvent-Free Method Using a Twin Screw Melt Extruder · Hung Lin Lee · 2017 · 48 citations · Cited by this paper
  30. Ritonavir Form III: A New Polymorph After 24 Years · Xin Sheng Yao · 2022 · 48 citations · Cited by this paper
  31. Disproportionation of the calcium salt of atorvastatin in the presence of acidic excipients · Niels Peter Aae Christensen · 2012 · 39 citations · Cited by this paper
  32. The Selection of a Pharmaceutical Salt—The Effect of the Acidity of the Counterion on Its Solubility and Potential Biopharmaceutical Performance · Yan He · 2017 · 39 citations · Cited by this paper
  33. Amorphous Drug–Polymer Salt with High Stability under Tropical Conditions and Fast Dissolution: The Case of Clofazimine and Poly(acrylic acid) · Yue Gui · 2021 · 39 citations · Cited by this paper
  34. Salt Stability - Effect of Particle Size, Relative Humidity, Temperature and Composition on Salt to Free Base Conversion · Yi‐Ling Hsieh · 2014 · 37 citations · Cited by this paper
  35. Preformulation Study of a Poorly Water-Soluble Drug, α-Pentyl-3-(2-quinolinylmethoxy)benzenemethanol: Selection of the Base for Dosage Form Design · Abu T.M. Serajuddin · 1986 · 37 citations · Cited by this paper
  36. Assessing Supersaturation and Its Impact on In Vivo Bioavailability of a Low-Solubility Compound ABT-072 With a Dual pH, Two-Phase Dissolution Method · Yi Shi · 2016 · 29 citations · Cited by this paper
  37. Amorphous Drug–Polymer Salt with High Stability under Tropical Conditions and Fast Dissolution: The Challenging Case of Lumefantrine-PAA · Xin Sheng Yao · 2021 · 26 citations · Cited by this paper
  38. Impact of sertraline salt form on the oxidative stability in powder blends · Yi-Ling Hsieh · 2013 · 25 citations · Cited by this paper
  39. Effect of excipient properties, water activity, and water content on the disproportionation of a pharmaceutical salt · Mitulkumar A. Patel · 2018 · 24 citations · Cited by this paper

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