Research map: HopeFOL, or FOL of Problems? Leucovorin For Autistic Symptoms

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Papers in this map

  1. Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate · Daniel V. Santi · 1974 · 624 citations · Cited by this paper
  2. Patient-driven second opinions in oncology: a review · 2026 · Related
  3. The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: a prospective randomized phase III trial. Gastrointestinal Tumor Study Group. · Nicholas James Petrelli · 1989 · 557 citations · Cited by this paper
  4. Proton-Pump Inhibitor use in combination with a CDK4/6 inhibitor: Is formulation the issue? · 2026 · Related
  5. Evidence‐based practice improves patient outcomes and healthcare system return on investment: Findings from a scoping review · Linda H. Connor · 2023 · 396 citations · Cited by this paper
  6. Durable response to sotorasib in KRAS G12C -mutant intrahepatic cholangiocarcinoma: a case report · 2026 · Related
  7. Biochemical modulation of fluorouracil with leucovorin: confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer. · Michael A. Poon · 1991 · 377 citations · Cited by this paper
  8. Neoadjuvant intent anti-programmed death-1 immunotherapy for cutaneous squamous cell carcinoma in patients with hematologic malignancy · 2026 · Related
  9. Phase II study of fluorouracil and its modulation in advanced colorectal cancer: a Southwest Oncology Group study. · Cynthia Gail Leichman · 1995 · 362 citations · Cited by this paper
  10. Use of liposomal irinotecan with 5-FU and oxaliplatin (NALIRIFOX) in neoadjuvant pancreatic adenocarcinoma: NEO-Nal-IRI trial · 2026 · Related
  11. Drug Shortage: Causes, Impact, and Mitigation Strategies · Sundus Shukar · 2021 · 326 citations · Cited by this paper
  12. Renal Dysfunction in Patients with CML on Long-Term First-Line TKI Therapy: A Single-Center Analysis · 2026 · Related
  13. Comparison of fluorouracil with additional levamisole, higher-dose folinic acid, or both, as adjuvant chemotherapy for colorectal cancer: a randomised trial · Gray, R. G. · 2000 · 232 citations · Cited by this paper
  14. SERENA-6 visual patient-reported outcomes & safety: camizestrant for emerging ESR1 m advanced breast cancer during first-line endocrine-basedtherapy · 2026 · Related
  15. Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial · Richard E. Frye · 2016 · 218 citations · Cited by this paper
  16. The Role of Adjuvant Chemotherapy in Small Bowel Adenocarcinomas · 2026 · Related
  17. A phase III trial of 5-fluorouracil and leucovorin in the treatment of advanced colorectal cancer. A mayo clinic/north central cancer treatment group study · M J O'Connell · 1989 · 207 citations · Cited by this paper
  18. Oncofertility in Gastrointestinal (GI) Oncology – A Pan-European study of the patient perspective · 2026 · Related
  19. Effect of 5,10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2'-deoxyuridylate from thymidylate synthetase: evidence for an ordered mechanism · Peter V. Danenberg · 1978 · 174 citations · Cited by this paper
  20. Weekly high-dose leucovorin versus low-dose leucovorin combined with fluorouracil in advanced colorectal cancer: results of a randomized multicenter trial. Study Group for Palliative Treatment of Metastatic Colorectal Cancer Study Protocol 1. · Elke Jäger · 1996 · 122 citations · Cited by this paper
  21. National survey on the effect of oncology drug shortages on cancer care · Ali McBride · 2013 · 118 citations · Cited by this paper
  22. Eradication Of Leukaemic Cells (L1210) by Methotrexate and Methotrexate Plus Citrovorum Factor · A Goldin · 1966 · 114 citations · Cited by this paper
  23. The Impact of Drug Shortages on Children with Cancer — The Example of Mechlorethamine · Monika L. Metzger · 2012 · 105 citations · Cited by this paper
  24. Chemistry of Leucovorin · Donna B. Cosulich · 1952 · 100 citations · Cited by this paper
  25. Cerebral folate deficiency: Analytical tests and differential diagnosis · Simon A. S. Pope · 2019 · 90 citations · Cited by this paper
  26. Leucovorin enhancement of the effects of the fluoropyrimidines on thymidylate synthase · Richard G. Moran · 1989 · 77 citations · Cited by this paper
  27. Impact of shortages of injectable oncology drugs on patient care · Jennifer C. Goldsack · 2014 · 55 citations · Cited by this paper
  28. Folinic acid improves the score of Autism in the EFFET placebo-controlled randomized trial · Émeline Renard · 2020 · 54 citations · Cited by this paper
  29. Treatment of Folate Metabolism Abnormalities in Autism Spectrum Disorder · Richard E. Frye · 2020 · 50 citations · Cited by this paper
  30. National Survey on the Effect of Oncology Drug Shortages in Clinical Practice: A Hematology Oncology Pharmacy Association Survey · Ali McBride · 2022 · 40 citations · Cited by this paper
  31. Association between high-dose methotrexate-induced toxicity and polymorphisms within methotrexate pathway genes in acute lymphoblastic leukemia · Meng Xu · 2022 · 38 citations · Cited by this paper
  32. RETRACTED ARTICLE: Efficacy of oral folinic acid supplementation in children with autism spectrum disorder: a randomized double-blind, placebo-controlled trial · Prateek Kumar Panda · 2024 · 38 citations · Cited by this paper
  33. A Prospective Randomized Study Comparing High- and Low-Dose Leucovorin Combined With Same-Dose 5-Fluorouracil in Advanced Colorectal Cancer · Marc Ychou · 1998 · 22 citations · Cited by this paper
  34. Drug Shortages in Oncology: ASCO Clinical Guidance for Alternative Treatments · Edgardo S. Santos · 2023 · 20 citations · Cited by this paper
  35. Folic Acid-Metabolizing Enzymes Regulate the Antitumor Effect of 5-Fluoro-2′-Deoxyuridine in Colorectal Cancer Cell Lines · Hiroshi Tsukihara · 2016 · 17 citations · Cited by this paper
  36. Effects of the leucovorin shortage: Pilot study investigating cost, efficacy, and toxicity comparison of low fixed-dose versus body surface area-adjusted leucovorin dosing in patients with resectable colon or metastatic colorectal cancer · Brandon R. Shank · 2016 · 11 citations · Cited by this paper
  37. Changes in paracetamol and leucovorin use after a White House briefing · Jeremy Samuel Faust · 2026 · 10 citations · Cited by this paper
  38. High- versus low-dose leucovorin in the modified FOLFOX6 regimen for first-line treatment of metastatic colorectal cancer · Jana Marie Reynolds · 2016 · 7 citations · Cited by this paper
  39. Efficacy and safety of high‐dose vs low‐dose leucovorin in patients with colorectal cancer: systematic review and meta‐analysis · Chin-Yu Hsu · 2019 · 7 citations · Cited by this paper

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