Research map: Safety and Efficacy of Allogeneic Integrin α10β1-Selected Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis: A First-In-Human Phase I/IIa Dose Escalation Study

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  1. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement · Massimo Dominici · 2006 · 18043 citations · Cited by this paper
  2. Quantitative Magnetic Resonance Spectroscopy and T2 Mapping for Evaluating Knee Subchondral Bone and Cartilage Changes in Chronic Kidney Disease · 2026 · Related
  3. The Knee injury and Osteoarthritis Outcome Score (KOOS): from joint injury to osteoarthritis. · Ewa Maria Roos · 2003 · 2407 citations · Cited by this paper
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  9. Functional heterogeneity of mesenchymal stem cells: Implications for cell therapy · Donald G. Phinney · 2012 · 455 citations · Cited by this paper
  10. Leucine Attenuates Osteoarthritis via mTORC1/LXRα-Mediated Macrophage Reprogramming and Rspo2/β-Catenin Axis Suppression · 2025 · Related
  11. Adult Human Mesenchymal Stem Cells Delivered via Intra-Articular Injection to the Knee Following Partial Medial Meniscectomy · C. Thomas Vangsness · 2014 · 409 citations · Cited by this paper
  12. MiRNA-140-5p Modulates Cartilage Mechanical Environment by Preserving Surface Stress Homeostasis · 2025 · Related
  13. Efficacy and safety of adult human bone marrow-derived, cultured, pooled, allogeneic mesenchymal stromal cells (Stempeucel®): preclinical and clinical trial in osteoarthritis of the knee joint · Pawan Kumar Gupta · 2016 · 331 citations · Cited by this paper
  14. Starch-Gelatin-Based Scaffolds for Cartilage Defect Repair: An in vitro Study Supporting Its Potential Clinical Use · 2025 · Related
  15. Treatment of knee osteoarthritis with intra-articular injection of autologous adipose-derived mesenchymal progenitor cells: a prospective, randomized, double-blind, active-controlled, phase IIb clinical trial · Liangjing Lu · 2019 · 269 citations · Cited by this paper
  16. Socioeconomic Area Deprivation is Related to Poorer Patient-Reported Outcomes Following Autologous Chondrocyte Implantation (ACI) · 2025 · Related
  17. Heterogeneity of mesenchymal stromal cell preparations · Anthony Dick Ho · 2008 · 267 citations · Cited by this paper
  18. miR-708-5p Attenuates Osteoarthritis Progression via Multi-Target Modulation of the NOX4/NF-κB Axis and Cartilage Homeostasis · 2025 · Related
  19. Allogeneic Mesenchymal Stem Cells Stimulate Cartilage Regeneration and Are Safe for Single-Stage Cartilage Repair in Humans upon Mixture with Recycled Autologous Chondrons · Tommy S. de Windt · 2016 · 245 citations · Cited by this paper
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  21. Compositional MRI techniques for evaluation of cartilage degeneration in osteoarthritis · Ali Guermazi · 2015 · 236 citations · Cited by this paper
  22. Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: a longitudinal study · Stephanie K. Tanamas · 2010 · 227 citations · Cited by this paper
  23. A systematic review of the relationship between subchondral bone features, pain and structural pathology in peripheral joint osteoarthritis · Andrew Barr · 2015 · 178 citations · Cited by this paper
  24. Safety, tolerability and efficacy of intra-articular Progenza in knee osteoarthritis: a randomized double-blind placebo-controlled single ascending dose study · D. Kuah · 2018 · 122 citations · Cited by this paper
  25. Treatment of knee osteoarthritis with intra-articular injection of allogeneic adipose-derived stem cells (ADSCs) ELIXCYTE®: a phase I/II, randomized, active-control, single-blind, multiple-center clinical trial · Cheng‐Fong Chen · 2021 · 88 citations · Cited by this paper
  26. The efficacy, accuracy and complications of corticosteroid injections of the knee joint · James G. McGarry · 2011 · 79 citations · Cited by this paper
  27. Multi-compositional MRI evaluation of repair cartilage in knee osteoarthritis with treatment of allogeneic human adipose-derived mesenchymal progenitor cells · Xinxin Zhao · 2019 · 75 citations · Cited by this paper
  28. Is there an optimal age for total knee arthroplasty?: A systematic review · Seung Hoon Lee · 2020 · 75 citations · Cited by this paper
  29. Association of subchondral bone marrow lesion localization with weight-bearing pain in people with knee osteoarthritis: data from the Osteoarthritis Initiative · Koji Aso · 2021 · 74 citations · Cited by this paper
  30. Integrin α10β1-Selected Mesenchymal Stem Cells Mitigate the Progression of Osteoarthritis in an Equine Talar Impact Model · Michelle L. Delco · 2020 · 63 citations · Cited by this paper
  31. Intra-Articular Injections of Allogeneic Human Adipose-Derived Mesenchymal Progenitor Cells in Patients with Symptomatic Bilateral Knee Osteoarthritis: A Phase I pilot study · Liangjing Lu · 2020 · 46 citations · Cited by this paper
  32. Influence of Platelet Concentration on the Clinical Outcome of Platelet-Rich Plasma Injections in Knee Osteoarthritis · Angelo Boffa · 2024 · 42 citations · Cited by this paper
  33. Human integrin α10β1-selected mesenchymal stem cells home to cartilage defects in the rabbit knee and assume a chondrocyte-like phenotype · Camilla Fuchs Andersen · 2022 · 29 citations · Cited by this paper
  34. Advanced MR Imaging for Knee Osteoarthritis: A Review on Local and Brain Effects · Carlo Augusto Mallio · 2022 · 24 citations · Cited by this paper
  35. Effect of mesenchymal stromal cells transplantation on the outcomes of patients with knee osteoarthritis: A systematic review and meta‐analysis · Rong-Hui Xie · 2023 · 21 citations · Cited by this paper
  36. Knee Osteoarthritis: Clinical and MRI Outcomes After Multiple Intra-Articular Injections With Expanded Autologous Adipose-Derived Stromal Cells or Platelet-Rich Plasma · Miguel A. Khoury · 2023 · 20 citations · Cited by this paper
  37. Relative efficacy and safety of mesenchymal stem cells for osteoarthritis: a systematic review and meta-analysis of randomized controlled trials · Xiaoyuan Tian · 2024 · 20 citations · Cited by this paper
  38. Safety and efficacy of an allogeneic adipose-derived mesenchymal stem cell preparation in the treatment of knee osteoarthritis: A Phase I/IIa randomised controlled trial · Julien Freitag · 2024 · 18 citations · Cited by this paper
  39. Prospects of Disease-Modifying Osteoarthritis Drugs · Win Min Oo · 2024 · 17 citations · Cited by this paper

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