Research map: The bile acid receptor TGR5 promotes functional recovery after spinal cord injury by rescuing mitochondrial dysfunction and suppressing AIM2‐mediated pyroptosis

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  1. limma powers differential expression analyses for RNA-sequencing and microarray studies · Matthew E. Ritchie · 2015 · 44581 citations · Cited by this paper
  2. Activation of sigma non‐opioid intracellular receptor 1 (S1R) receptor inhibits plexin domain containing 2 (Plxdc2) driven microglial inflammation to ameliorate depressive‐like behaviours in mice · 2026 · Related
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  15. CD73 alleviates GSDMD‐mediated microglia pyroptosis in spinal cord injury through PI3K/AKT/Foxo1 signaling · Shun Xu · 2020 · 248 citations · Cited by this paper
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  17. Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling · Jianping Hu · 2021 · 238 citations · Cited by this paper
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  19. G Protein-Coupled Bile Acid Receptor TGR5 Activation Inhibits Kidney Disease in Obesity and Diabetes · Xiaoxin X. Wang · 2015 · 214 citations · Cited by this paper
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  22. Gasdermins and pyroptosis in the kidney · Esteban E. Elias · 2023 · 191 citations · Cited by this paper
  23. The neuroanatomical–functional paradox in spinal cord injury · Karim Fouad · 2020 · 166 citations · Cited by this paper
  24. Clinical relevance of the bile acid receptor TGR5 in metabolism · F. Samuel van Nierop · 2016 · 160 citations · Cited by this paper
  25. Overexpression of NAG-1/GDF15 prevents hepatic steatosis through inhibiting oxidative stress-mediated dsDNA release and AIM2 inflammasome activation · Ying Wang · 2022 · 120 citations · Cited by this paper
  26. AIM2 promotes the development of non-small cell lung cancer by modulating mitochondrial dynamics · Qi Miao · 2020 · 106 citations · Cited by this paper
  27. Refining rodent models of spinal cord injury · Elliot J. Lilley · 2020 · 102 citations · Cited by this paper
  28. TGR5 supresses cGAS/STING pathway by inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial coupling in diabetic retinopathy · Yan Li · 2023 · 81 citations · Cited by this paper
  29. TGR5-mediated lateral hypothalamus-dCA3-dorsolateral septum circuit regulates depressive-like behavior in male mice · Xu-Yi Li · 2024 · 73 citations · Cited by this paper
  30. TGR5 deficiency activates antitumor immunity in non-small cell lung cancer via restraining M2 macrophage polarization · Lifang Zhao · 2021 · 69 citations · Cited by this paper
  31. Mitochondrial DNA leakage: underlying mechanisms and therapeutic implications in neurological disorders · Guangming Zhang · 2025 · 68 citations · Cited by this paper
  32. Heterogeneity analysis of astrocytes following spinal cord injury at single‐cell resolution · Jinxing Hou · 2022 · 65 citations · Cited by this paper
  33. The role of FXR and TGR5 in reversing and preventing progression of Western diet–induced hepatic steatosis, inflammation, and fibrosis in mice · Xiaoxin X. Wang · 2022 · 63 citations · Cited by this paper
  34. Gut microbiota-mediated ursodeoxycholic acids regulate the inflammation of microglia through TGR5 signaling after MCAO · Feng Zhang · 2023 · 63 citations · Cited by this paper
  35. Exosomes derived from schwann cells alleviate mitochondrial dysfunction and necroptosis after spinal cord injury via AMPK signaling pathway-mediated mitophagy · Bo Xu · 2023 · 53 citations · Cited by this paper
  36. Mitophagy in Cell Death Regulation: Insights into Mechanisms and Disease Implications · Jiani Lin · 2024 · 53 citations · Cited by this paper
  37. Knockdown of the AIM2 molecule attenuates ischemia-reperfusion-induced spinal neuronal pyroptosis by inhibiting AIM2 inflammasome activation and subsequent release of cleaved caspase-1 and IL-1β · Xiaoqian Li · 2019 · 48 citations · Cited by this paper
  38. Cyclic helix B peptide alleviates proinflammatory cell death and improves functional recovery after traumatic spinal cord injury · Yu Ming Xu · 2023 · 47 citations · Cited by this paper
  39. TGR5 deficiency in excitatory neurons ameliorates Alzheimer’s pathology by regulating APP processing · Chenli Li · 2024 · 40 citations · Cited by this paper

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