Research map: Beyond the N-terminus: Emerging regulatory roles of the middle and C-terminal domains of cardiac myosin binding protein-C

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  1. Prevalence of Hypertrophic Cardiomyopathy in a General Population of Young Adults · Barry J. Maron · 1995 · 2297 citations · Cited by this paper
  2. From antioxidant hype to mitochondrial reality: Quercetin modulates cardiac redox balance but fails to restore mitochondrial respiration parameters in Zucker diabetic fatty rats · 2026 · Related
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  5. A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression · Edward L. Huttlin · 2010 · 1879 citations · Cited by this paper
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  7. PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse · Peter V. Hornbeck · 2011 · 1740 citations · Cited by this paper
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  9. 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association · Seth Shay Martin · 2025 · 1044 citations · Cited by this paper
  10. CYLD-mediated DNA damage coordinates pathological cardiac hypertrophy via RIPK1-dependent signaling · 2026 · Related
  11. 2024 AHA/ACC/AMSSM/HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines · Steve R. Ommen · 2024 · 726 citations · Cited by this paper
  12. A review of peroxisome biology: Potential implications for cardiac physiology and pathology · 2026 · Related
  13. Prevalence, Clinical Profile, and Significance of Left Ventricular Remodeling in the End-Stage Phase of Hypertrophic Cardiomyopathy · Kevin M. Harris · 2006 · 673 citations · Cited by this paper
  14. Cardiomyopathy and aging integrally contribute to the unfolded protein response collective pathways · 2026 · Related
  15. Mutations in the cardiac myosin binding protein–C gene on chromosome 11 cause familial hypertrophic cardiomyopathy · Hugh C Watkins · 1995 · 593 citations · Cited by this paper
  16. Pathophysiology and pharmacotherapy of cardiovascular complications in metabolic syndrome · 2026 · Related
  17. Cardiac myosin binding protein–C gene splice acceptor site mutation is associated with familial hypertrophic cardiomyopathy · Gisèle Bonne · 1995 · 445 citations · Cited by this paper
  18. Melatonin promotes coronary angiogenesis and ameliorates cardiac dysfunction after myocardial infarction via endothelial LRRC8A · 2026 · Related
  19. Phosphorylation switches specific for the cardiac isoform of myosin binding protein‐C: a modulator of cardiac contraction? · Mathias Gautel · 1995 · 416 citations · Cited by this paper
  20. Post-translational modifications of cardiac myosin-binding protein-C: Mechanisms behind fine-tuning the sarcomere · 2026 · Related
  21. Atomic model of a myosin filament in the relaxed state · John L. Woodhead · 2005 · 376 citations · Cited by this paper
  22. Myosin ATP turnover rate is a mechanism involved in thermogenesis in resting skeletal muscle fibers · Melanie A. Stewart · 2009 · 350 citations · Cited by this paper
  23. Towards a molecular understanding of titin. · Siegfried Labeit · 1992 · 349 citations · Cited by this paper
  24. Cardiac Myosin Binding Protein C · Emily Flashman · 2004 · 329 citations · Cited by this paper
  25. Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations · Jens Mogensen · 2003 · 302 citations · Cited by this paper
  26. A Molecular Map of the Interactions between Titin and Myosin‐Binding Protein C · Alexandra Freiburg · 1996 · 280 citations · Cited by this paper
  27. Phosphorylation and function of cardiac myosin binding protein-C in health and disease · David Y. Barefield · 2009 · 274 citations · Cited by this paper
  28. Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice · Bradley K. McConnell · 1999 · 262 citations · Cited by this paper
  29. Muscle Giants: Molecular Scaffolds in Sarcomerogenesis · Aikaterini Kontrogianni‐Konstantopoulos · 2009 · 258 citations · Cited by this paper
  30. Mutations in β-myosin S2 that cause familial hypertrophic cardiomyopathy (FHC) abolish the interaction with the regulatory domain of myosin-binding protein-C 1 1Edited by J. Karn · Mathias Gruen · 1999 · 245 citations · Cited by this paper
  31. The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations · Suman Nag · 2017 · 241 citations · Cited by this paper
  32. In the Thick of It · Samantha P. Harris · 2011 · 234 citations · Cited by this paper
  33. Cardiac Myosin-Binding Protein-C Phosphorylation and Cardiac Function · Sakthivel Sadayappan · 2005 · 232 citations · Cited by this paper
  34. Clinicopathological profiles of progressive heart failure in hypertrophic cardiomyopathy · Paola Melacini · 2010 · 231 citations · Cited by this paper
  35. Myosin Binding Protein C, a Phosphorylation-Dependent Force Regulator in Muscle That Controls the Attachment of Myosin Heads by Its Interaction With Myosin S2 · Gudrun Kunst · 2000 · 230 citations · Cited by this paper
  36. The Myosin-binding Protein C Motif Binds to F-actin in a Phosphorylation-sensitive Manner · Justin Franklin Shaffer · 2009 · 217 citations · Cited by this paper
  37. Cardiac myosin binding protein c phosphorylation is cardioprotective · Sakthivel Sadayappan · 2006 · 215 citations · Cited by this paper
  38. Polypeptide chains of intermediate molecular weight in myosin preparations · Roger Starr · 1971 · 211 citations · Cited by this paper
  39. The major myosin-binding domain of skeletal muscle MyBP-C (C protein) resides in the COOH-terminal, immunoglobulin C2 motif. · T. Okagaki · 1993 · 210 citations · Cited by this paper

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