Research map: COL1A1 regulates the progression of dry eye disease through metabolic reprogramming and inflammatory responses via the HIF1A/HK2 pathway

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  1. HIF-1: mediator of physiological and pathophysiological responses to hypoxia · Gregg L. Semenza · 2000 · 1839 citations · Cited by this paper
  2. Mitochondrial Dysfunction and Diabetic Retinopathy: Research Progress from Pathogenic Mechanisms to Therapeutic Targets · 2026 · Related
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  4. Inflammatory stress disrupts retinal lactate homeostasis under high-altitude hypoxia · 2026 · Related
  5. Role of Hyperosmolarity in the Pathogenesis and Management of Dry Eye Disease: Proceedings of the OCEAN Group Meeting · Christophe Baudouin · 2013 · 509 citations · Cited by this paper
  6. To delineate the role of Zinc Alpha 2 Glycoprotein in the pathophysiology of diabetic retinopathy using in vitro models of retinal endothelial cells and pericytes · 2026 · Related
  7. Tear analysis in ocular surface diseases · Lei Zhou · 2012 · 318 citations · Cited by this paper
  8. Physcion alleviates Aspergillus fumigatus keratitis by inhibiting fungal growth and NF-κB–mediated inflammation · 2026 · Related
  9. HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection · Valerie P. Tan · 2015 · 316 citations · Cited by this paper
  10. Mesenchymal stem cell-derived conditioned medium demonstrates antifungal activity against ocular isolates of Candida albicans and Aspergillus flavus: a proof-of-concept study · 2026 · Related
  11. Defining Dry Eye from a Clinical Perspective · Kazuo Tsubota · 2020 · 283 citations · Cited by this paper
  12. Correcting photoreceptor diseases at their source: CRISPR strategies for cone-rod dystrophy and achromatopsia · 2026 · Related
  13. Composition, structure and function of the corneal stroma · Edgar M. Espana · 2020 · 252 citations · Cited by this paper
  14. Inhibition of STAT6 signaling by rebamipide attenuates IL-4- and IL-13-induced eotaxin expression in corneal fibroblasts · 2026 · Related
  15. TFOS DEWS III: Diagnostic Methodology · James S. Wolffsohn · 2025 · 206 citations · Cited by this paper
  16. A unified developmental timeline of pigmented ocular tissues in the mouse eye · 2026 · Related
  17. Dry Eye Disease · Farida Esaa Hakim · 2022 · 124 citations · Cited by this paper
  18. Oral crocin promotes corneal epithelial healing and attenuates opacity and neovascularization in a rat model of alkali-induced corneal injury · 2026 · Related
  19. Reviewing the Regulators of COL1A1 · Hanne Devos · 2023 · 116 citations · Cited by this paper
  20. Understanding the ocular accumulation of mefuparib and its N-dealkylation metabolite: Pharmacokinetics, melanin affinity, and cellular disposition · 2026 · Related
  21. MicroRNAs of extracellular vesicles derived from mesenchymal stromal cells alleviate inflammation in dry eye disease by targeting the IRAK1/TAB2/NF-κB pathway · Leying Wang · 2023 · 67 citations · Cited by this paper
  22. Integrated Tear Proteome and Metabolome Reveal Panels of Inflammatory-Related Molecules via Key Regulatory Pathways in Dry Eye Syndrome · Xueli Chen · 2019 · 62 citations · Cited by this paper
  23. The role of oxidative stress in the pathogenesis of ocular diseases: an overview · Miao Zhang · 2024 · 51 citations · Cited by this paper
  24. Alterations in corneal biomechanics underlie early stages of autoimmune-mediated dry eye disease · Yael Efraim · 2020 · 31 citations · Cited by this paper
  25. Hyperosmolarity promotes macrophage pyroptosis by driving the glycolytic reprogramming of corneal epithelial cells in dry eye disease · Yu Han · 2023 · 31 citations · Cited by this paper
  26. ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner · Rong-Kun Li · 2024 · 26 citations · Cited by this paper
  27. Genetically inspired organoids prevent joint degeneration and alleviate chondrocyte senescence via Col11a1–HIF1α‐mediated glycolysis–OXPHOS metabolism shift · Ye Sun · 2024 · 19 citations · Cited by this paper
  28. Gene Expression Profile of Extracellular Matrix and Adhesion Molecules in the Human Normal Corneal Stroma · Ying Liu · 2016 · 12 citations · Cited by this paper
  29. Plasma type I collagen α1 chain in relation to coronary artery disease: findings from a prospective population-based cohort and an acute myocardial infarction prospective cohort in Sweden · Filip Hammaréus · 2023 · 7 citations · Cited by this paper
  30. Protective effects and mechanisms of lactoferrin and HIF-1α on dry eye syndrome in mice · Shanshan Sun · 2025 · 5 citations · Cited by this paper

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