Research map: Strategies to prevent HNSCC by chewing gum delivery of enzymes/antimicrobials to reduce carcinogenic acetaldehyde produced by pathogenic microbes

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  1. Targeting microbial biofilms: current and prospective therapeutic strategies · Hyun Min KOO · 2017 · 1830 citations · Cited by this paper
  2. Rethinking lymphodepleting preconditioning in adoptive T cell therapy for durable tumor control · 2026 · Related
  3. Biology of Streptococcus mutans-Derived Glucosyltransferases: Role in Extracellular Matrix Formation of Cariogenic Biofilms · W.H. Bowen · 2011 · 1067 citations · Cited by this paper
  4. Depletion of IL-10 in CAR-NK cells augments reprogramming of the tumor microenvironment and ameliorates therapeutic efficacy · 2026 · Related
  5. Oral Microbiome: A Review of Its Impact on Oral and Systemic Health · John J. Rajasekaran · 2024 · 239 citations · Cited by this paper
  6. Rethinking “Safe” Drinking: A Review of the Carcinogenic Risks of Alcohol Consumption · 2026 · Related
  7. Beyond microbial community composition: functional activities of the oral microbiome in health and disease · Ana E. Duran-Pinedo · 2015 · 215 citations · Cited by this paper
  8. AGTR1 signaling contributes to tumor immunity and therapy response in non-small cell lung cancer · 2026 · Related
  9. Candida albicans Yeast, Pseudohyphal, and Hyphal Morphogenesis Differentially Affects Immune Recognition · Liliane Mukaremera · 2017 · 210 citations · Cited by this paper
  10. CART-immune-related adverse events after BCMA CAR-T therapy · 2026 · Related
  11. Plant-Derived Antimicrobials and Their Crucial Role in Combating Antimicrobial Resistance · Paola Angelini · 2024 · 166 citations · Cited by this paper
  12. Unmasking Wnt-driven HCC: Inhibiting SMYD2 to overcome immune resistance · 2026 · Related
  13. Acetaldehyde and the genome: Beyond nuclear DNA adducts and carcinogenesis · Philip John Brooks · 2013 · 154 citations · Cited by this paper
  14. Intraperitoneal delivery of the oncolytic virus CF17 improves tumor immunogenicity and survival in gastric cancer peritoneal metastasis · 2026 · Related
  15. The pathobiology of human fungal infections · Gordon D. Brown · 2024 · 153 citations · Cited by this paper
  16. Synergistic Cell-Cycle Repression by HDAC/EZH2 Co-Targeting in H3K27-Altered Diffuse Midline Glioma · 2026 · Related
  17. Oral Commensal Streptococci: Gatekeepers of the Oral Cavity · Joshua J. Baty · 2022 · 151 citations · Cited by this paper
  18. Natural killer cell-derived extracellular vesicles reprogram cellular human immunity to enhance tumor cytotoxicity · 2026 · Related
  19. Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease · Martin Hoenigl · 2024 · 148 citations · Cited by this paper
  20. CAR design equips diverse immune cells with unique antigen-specific activation identities · 2026 · Related
  21. Expression and characterization of antimicrobial peptides Retrocyclin‐101 and Protegrin‐1 in chloroplasts to control viral and bacterial infections · Seung-Bum Lee · 2010 · 144 citations · Cited by this paper
  22. Microbially produced acetaldehyde from ethanol may increase the risk of colon cancer via folate deficiency · Nils Homann · 2000 · 138 citations · Cited by this paper
  23. Fusobacterium nucleatum Metabolically Integrates Commensals and Pathogens in Oral Biofilms · Akito Sakanaka · 2022 · 134 citations · Cited by this paper
  24. Clinical Benefit and Regulatory Outcomes of Cancer Drugs Receiving Accelerated Approval · Ian T. T. Liu · 2024 · 127 citations · Cited by this paper
  25. Candida albicans Enhances the Progression of Oral Squamous Cell Carcinoma In Vitro and In Vivo · Máté Vadovics · 2022 · 113 citations · Cited by this paper
  26. Acetaldehyde as a common denominator and cumulative carcinogen in digestive tract cancers · Mikko P. Salaspuro · 2009 · 104 citations · Cited by this paper
  27. The IARC Perspective on Alcohol Reduction or Cessation and Cancer Risk · Susan M. Gapstur · 2023 · 100 citations · Cited by this paper
  28. Estimation of Cancer Deaths Averted From Prevention, Screening, and Treatment Efforts, 1975-2020 · Katrina A.B. Goddard · 2024 · 93 citations · Cited by this paper
  29. Association or Causation? Exploring the Oral Microbiome and Cancer Links · Flavia Teles · 2020 · 91 citations · Cited by this paper
  30. Single-cell and spatial dissection of precancerous lesions underlying the initiation process of oral squamous cell carcinoma · Lulu Sun · 2023 · 85 citations · Cited by this paper
  31. Short-term salivary acetaldehyde increase due to direct exposure to alcoholic beverages as an additional cancer risk factor beyond ethanol metabolism · Dirk W. Lachenmeier · 2011 · 82 citations · Cited by this paper
  32. A Phase III, Randomized, Double-blind, Placebo-controlled, Multinational Trial of Iseganan for the Prevention of Oral Mucositis in Patients Receiving Stomatotoxic Chemotherapy (PROMPT-CT Trial) · Francis Joseph Giles · 2003 · 76 citations · Cited by this paper
  33. A phase III, randomized, double-blind, placebo-controlled, study of iseganan for the reduction of stomatitis in patients receiving stomatotoxic chemotherapy · Francis Joseph Giles · 2003 · 75 citations · Cited by this paper
  34. Metabolic property of acetaldehyde production from ethanol and glucose by oral Streptococcus and Neisseria · Ryo Tagaino · 2019 · 71 citations · Cited by this paper
  35. Debulking SARS-CoV-2 in saliva using angiotensin converting enzyme 2 in chewing gum to decrease oral virus transmission and infection · Henry Daniell · 2021 · 71 citations · Cited by this paper
  36. Topical delivery of low-cost protein drug candidates made in chloroplasts for biofilm disruption and uptake by oral epithelial cells · Yuan Liu · 2016 · 67 citations · Cited by this paper
  37. Multiple alcohol dehydrogenases but no functional acetaldehyde dehydrogenase causing excessive acetaldehyde production from ethanol by oral streptococci · Sylvia I. Pavlova · 2013 · 66 citations · Cited by this paper
  38. Candida albicans Promotes Oral Cancer via IL-17A/IL-17RA-Macrophage Axis · Xu Wang · 2023 · 64 citations · Cited by this paper
  39. Oral microbiota and oral squamous cell carcinoma: a review of their relation and carcinogenic mechanisms · Bayu Indra Sukmana · 2024 · 63 citations · Cited by this paper

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