Research map: Exercise-induced myokine irisin protects against obesity-associated ischemic stroke via integrin αVβ5 signaling

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  1. Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 · Valery L. Feigin · 2021 · 8115 citations · Cited by this paper
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  13. Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway · Christiane D. Wrann · 2013 · 1441 citations · Cited by this paper
  14. Hematopoietic and T-lymphopoiesis-stimulating effects of a fluorinated pyrazolopiperidine β-cyclodextrin complex in cyclophosphamide-induced hematopoietic suppression · 2026 · Related
  15. Irisin Is Expressed and Produced by Human Muscle and Adipose Tissue in Association With Obesity and Insulin Resistance · José María Moreno‐Navarrete · 2013 · 804 citations · Cited by this paper
  16. Ganhai Weikang Capsules ameliorate functional dyspepsia in rats by modulating gut microbiota and host metabolic homeostasis · 2026 · Related
  17. Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke · Xiao‐Yi Xiong · 2016 · 741 citations · Cited by this paper
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  19. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors · Hyeonwoo Kim · 2018 · 641 citations · Cited by this paper
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  21. Aging and ischemic stroke · Mohammed Yousufuddin · 2019 · 448 citations · Cited by this paper
  22. 2024 Guideline for the Primary Prevention of Stroke: A Guideline From the American Heart Association/American Stroke Association · Cheryl Bushnell · 2024 · 355 citations · Cited by this paper
  23. The novel exercise-induced hormone irisin protects against neuronal injury via activation of the Akt and ERK1/2 signaling pathways and contributes to the neuroprotection of physical exercise in cerebral ischemia · Dongjie Li · 2016 · 308 citations · Cited by this paper
  24. Focus on the Role of NLRP3 Inflammasome in Diseases · Roberta Fusco · 2020 · 292 citations · Cited by this paper
  25. Cognitive impairment and memory dysfunction after a stroke diagnosis: a post-stroke memory assessment · Noor Kamal Al-Qazzaz · 2014 · 283 citations · Cited by this paper
  26. Irisin ameliorates neuroinflammation and neuronal apoptosis through integrin αVβ5/AMPK signaling pathway after intracerebral hemorrhage in mice · Yao Wang · 2022 · 225 citations · Cited by this paper
  27. Microglia-mediated neuroinflammation and neuroplasticity after stroke · Yuan Wang · 2022 · 153 citations · Cited by this paper
  28. Obesity · Walter N. Kernan · 2012 · 144 citations · Cited by this paper
  29. Physical Activity in the Prevention and Treatment of Stroke · Siobhan Gallanagh · 2011 · 140 citations · Cited by this paper
  30. A Comparative Study of Variables Influencing Ischemic Injury in the Longa and Koizumi Methods of Intraluminal Filament Middle Cerebral Artery Occlusion in Mice · Gary P. Morris · 2016 · 130 citations · Cited by this paper
  31. Obesity-induced inflammation: connecting the periphery to the brain · Ophélia Le Thuc · 2024 · 119 citations · Cited by this paper
  32. Irisin Peptide Protects Brain Against Ischemic Injury Through Reducing Apoptosis and Enhancing BDNF in a Rodent Model of Stroke · Yasin Asadi · 2018 · 114 citations · Cited by this paper
  33. Muscle-Organ Crosstalk: Focus on Immunometabolism · Marie Lund Bay · 2020 · 111 citations · Cited by this paper
  34. Irisin protects against neuronal injury induced by oxygen-glucose deprivation in part depends on the inhibition of ROS-NLRP3 inflammatory signaling pathway · Juan Peng · 2017 · 106 citations · Cited by this paper
  35. Stroke in Young Adults · Syed Bukhari · 2023 · 106 citations · Cited by this paper
  36. Adiposity and risk of ischaemic and haemorrhagic stroke in 0·5 million Chinese men and women: a prospective cohort study · Zhengming Chen · 2018 · 104 citations · Cited by this paper
  37. Exercise for stroke prevention · Peter L. Prior · 2018 · 104 citations · Cited by this paper
  38. NLRP3 Inflammasome Activation: A Therapeutic Target for Cerebral Ischemia–Reperfusion Injury · Lixia Wang · 2022 · 98 citations · Cited by this paper
  39. Effects of irisin on the dysfunction of blood–brain barrier in rats after focal cerebral ischemia/reperfusion · Peipei Guo · 2019 · 92 citations · Cited by this paper

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