Research map: Mathematical Modeling of Systemic Sclerosis and Its Treatment

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  1. Transforming Growth Factor β in Tissue Fibrosis · Franklin H. Epstein · 1994 · 3091 citations · Cited by this paper
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  17. Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis · David Lagares · 2017 · 249 citations · Cited by this paper
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  19. Myofibroblasts: Function, Formation, and Scope of Molecular Therapies for Skin Fibrosis · Yifan Tai · 2021 · 247 citations · Cited by this paper
  20. New insights into fibrosis from the ECM degradation perspective: the macrophage-MMP-ECM interaction · Xiangyu Zhao · 2022 · 226 citations · Cited by this paper
  21. TGF-β in fibrosis by acting as a conductor for contractile properties of myofibroblasts · Alexandre Vallée · 2019 · 196 citations · Cited by this paper
  22. Solving PDEs in Python · Hans Petter Langtangen · 2016 · 172 citations · Cited by this paper
  23. Unraveling SSc Pathophysiology; The Myofibroblast · A. van Caam · 2018 · 152 citations · Cited by this paper
  24. ECM formation and degradation during fibrosis, repair, and regeneration · Alejandro E. Mayorca‐Guiliani · 2025 · 151 citations · Cited by this paper
  25. Dermal fibroblasts have different extracellular matrix profiles induced by TGF-β, PDGF and IL-6 in a model for skin fibrosis · Pernille Juhl · 2020 · 144 citations · Cited by this paper
  26. Newton-Raphson and Related Algorithms for Maximum Likelihood Variance Component Estimation · Robert I. Jennrich · 1976 · 132 citations · Cited by this paper
  27. A mathematical model of ischemic cutaneous wounds · Chuan Xue · 2009 · 122 citations · Cited by this paper
  28. Active Transforming Growth Factor-β in Wound Repair · Liju Yang · 1999 · 106 citations · Cited by this paper
  29. An Implicit-Explicit Runge--Kutta--Chebyshev Scheme for Diffusion-Reaction Equations · Jan G. Verwer · 2004 · 90 citations · Cited by this paper
  30. Collagen degradation by interleukin‐1β‐stimulated gingival fibroblasts is accompanied by release and activation of multiple matrix metalloproteinases and cysteine proteinases · SW Cox · 2005 · 77 citations · Cited by this paper
  31. The Mighty Fibroblast and Its Utility in Scleroderma Research · Sara M. Garrett · 2017 · 77 citations · Cited by this paper
  32. Mathematical model of sarcoidosis · Wenrui Hao · 2014 · 74 citations · Cited by this paper
  33. Fibroblast Subpopulations in Systemic Sclerosis: Functional Implications of Individual Subpopulations and Correlations with Clinical Features · Honglin Zhu · 2023 · 57 citations · Cited by this paper
  34. Mathematical Modeling of Interleukin-35 Promoting Tumor Growth and Angiogenesis · Kang‐Ling Liao · 2014 · 52 citations · Cited by this paper
  35. Cell mediated ECM-degradation as an emerging tool for anti-fibrotic strategy · Peng Zhao · 2023 · 49 citations · Cited by this paper
  36. Hitting the Target! Challenges and Opportunities for TGF-β Inhibition for the Treatment of Cardiac fibrosis · Maria Vistnes · 2024 · 44 citations · Cited by this paper
  37. Older age onset of systemic sclerosis – accelerated disease progression in all disease subsets · Pia Moinzadeh · 2020 · 40 citations · Cited by this paper
  38. Validation of a morphometric method for evaluating fibroblast numbers in normal and pathologic tissues · C. C. Miller · 2003 · 38 citations · Cited by this paper
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