Research map: Co-amorphization for solubility and dissolution rate improvement: the case of low-crystallization-tendency drugs

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Papers in this map

  1. Polymeric Amorphous Solid Dispersions: A Review of Amorphization, Crystallization, Stabilization, Solid-State Characterization, and Aqueous Solubilization of Biopharmaceutical Classification System Class II Drugs · Shrawan Baghel · 2016 · 977 citations · Cited by this paper
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  11. Co-Amorphous Solid Dispersions for Solubility and Absorption Improvement of Drugs: Composition, Preparation, Characterization and Formulations for Oral Delivery · Anna Karagianni · 2018 · 228 citations · Cited by this paper
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  13. Advances in coamorphous drug delivery systems · Qin Shi · 2018 · 198 citations · Cited by this paper
  14. Current status and trends of anti-tumor biosimilars in China from 2019 to 2023: A cross-sectional analysis · 2025 · Related
  15. Co amorphous systems: A product development perspective · Rahul B. Chavan · 2016 · 191 citations · Cited by this paper
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  17. Solubilization techniques used for poorly water-soluble drugs · Bing Xie · 2024 · 189 citations · Cited by this paper
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  19. Pharmaceutical approaches for enhancing solubility and oral bioavailability of poorly soluble drugs · Isaïe Nyamba · 2024 · 169 citations · Cited by this paper
  20. Co-Amorphous Drug Formulations in Numbers: Recent Advances in Co-Amorphous Drug Formulations with Focus on Co-Formability, Molar Ratio, Preparation Methods, Physical Stability, In Vitro and In Vivo Performance, and New Formulation Strategies · Jingwen Liu · 2021 · 161 citations · Cited by this paper
  21. Dissolution of Danazol Amorphous Solid Dispersions: Supersaturation and Phase Behavior as a Function of Drug Loading and Polymer Type · Matthew James Jackson · 2015 · 132 citations · Cited by this paper
  22. Preparation and characterization of spray-dried co-amorphous drug–amino acid salts · Katrine Tarp Jensen · 2015 · 130 citations · Cited by this paper
  23. Supersaturating drug delivery systems: The potential of co-amorphous drug formulations · Riikka Laitinen · 2017 · 124 citations · Cited by this paper
  24. Co-former selection for co-amorphous drug-amino acid formulations · Georgia Kasten · 2018 · 115 citations · Cited by this paper
  25. Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability · Amjad Alhalaweh · 2015 · 114 citations · Cited by this paper
  26. Evaluating the Role of Solubility in Oral Absorption of Poorly Water‐Soluble Drugs Using Physiologically‐Based Pharmacokinetic Modeling · Christina Fink · 2019 · 99 citations · Cited by this paper
  27. Crystallization Tendency of Pharmaceutical Glasses: Relevance to Compound Properties, Impact of Formulation Process, and Implications for Design of Amorphous Solid Dispersions · Kohsaku Kawakami · 2019 · 74 citations · Cited by this paper
  28. Physical stability of amorphous pharmaceutical solids: Nucleation, crystal growth, phase separation and effects of the polymers · Qin Shi · 2020 · 66 citations · Cited by this paper
  29. Coamorphous Loratadine-Citric Acid System with Enhanced Physical Stability and Bioavailability · Jin Wang · 2017 · 63 citations · Cited by this paper
  30. Indomethacin co-amorphous drug-drug systems with improved solubility, supersaturation, dissolution rate and physical stability · Hanan Fael · 2021 · 63 citations · Cited by this paper
  31. Glass Forming Ability of Amorphous Drugs Investigated by Continuous Cooling and Isothermal Transformation · Lasse Ingerslev Blaabjerg · 2016 · 61 citations · Cited by this paper
  32. New Perspectives for Fixed Dose Combinations of Poorly Water-Soluble Compounds: a Case Study with Ezetimibe and Lovastatin · Manoela Klüppel Riekes · 2016 · 59 citations · Cited by this paper
  33. Mechanical Activation by Ball Milling as a Strategy to Prepare Highly Soluble Pharmaceutical Formulations in the Form of Co-Amorphous, Co-Crystals, or Polymorphs · Luz María Martínez · 2022 · 58 citations · Cited by this paper
  34. A top-down technique to improve the solubility and bioavailability of aceclofenac: in vitro and in vivo studies · Reema Narayan · 2017 · 49 citations · Cited by this paper
  35. Recent advances in dual-drug co-amorphous systems · Rutuja Shelke · 2023 · 49 citations · Cited by this paper
  36. Influence of Glass Forming Ability on the Physical Stability of Supersaturated Amorphous Solid Dispersions · Lasse Ingerslev Blaabjerg · 2019 · 48 citations · Cited by this paper
  37. Combining drug salt formation with amorphous solid dispersions – a double edged sword · Tze Ning Hiew · 2022 · 47 citations · Cited by this paper
  38. Development, recent advances, and updates in binary, ternary co-amorphous systems, and ternary solid dispersions · Arezoo Saberi · 2023 · 45 citations · Cited by this paper
  39. “Felodipine-indomethacin” co-amorphous supersaturating drug delivery systems: “Spring-parachute” process, stability, in vivo bioavailability, and underlying molecular mechanisms · Ya-Wei Li · 2021 · 43 citations · Cited by this paper

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