Research map: Enhanced acetate uptake and metabolism in endothelial cells promote tumour angiogenesis and immunosuppression by increasing histone acetylation
Back to the article
Papers in this map
Hallmarks of Cancer: New Dimensions
· Douglas Hanahan · 2022 · 9836 citations · Cited by this paper
A patient-driven agenda for liver cirrhosis research
· 2026 · Related
Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma
· Richard S. Finn · 2020 · 7562 citations · Cited by this paper
International consensus on intestinal epithelial barrier assessment and therapeutic effects in inflammatory bowel diseases clinical trials
· 2026 · Related
Hepatocellular carcinoma
· Arndt Vogel · 2022 · 2425 citations · Cited by this paper
Toward a CKLM framework for integrated clinical trial design
· 2026 · Related
Angiogenic signaling pathways and anti-angiogenic therapy for cancer
· Zhenling Liu · 2023 · 1297 citations · Cited by this paper
Large language models for detecting colorectal polyps in endoscopic images—further research is required
· 2026 · Related
Modulation of cellular processes by histone and non-histone protein acetylation
· Maria Shvedunova · 2022 · 970 citations · Cited by this paper
USP20 promotes CD8 + T cell exhaustion and impairs KRAS G12D inhibitor efficacy by orchestrating cholesterol metabolism and autophagy in pancreatic cancer
· 2026 · Related
Deacetylase inhibition promotes the generation and function of regulatory T cells
· Ran N. Tao · 2007 · 923 citations · Cited by this paper
Galectin-14, a primate-specific oncofetal protein, impairs anti-tumour immunity in hepatocellular carcinoma by driving elevated heparan sulphate modification
· 2026 · Related
Metabolic reprogramming and epigenetic modifications on the path to cancer
· Linchong Sun · 2021 · 810 citations · Cited by this paper
Cancer neuroscience in cholangiocarcinoma: from perineural invasion to neuroimmune control
· 2026 · Related
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
· James E. Dahlman · 2014 · 593 citations · Cited by this paper
Cryptogenic steatotic liver disease: a lean phenotype associated with increased liver-related mortality
· 2026 · Related
Anti-angiogenic agents — overcoming tumour endothelial cell anergy and improving immunotherapy outcomes
· Zowi R. Huinen · 2021 · 431 citations · Cited by this paper
Safety and efficacy of extended surveillance intervals following colorectal endoscopic submucosal dissection: an international multicentre study
· 2026 · Related
Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity
· Qiang Feng · 2022 · 429 citations · Cited by this paper
Dysregulated sphingolipid metabolismdrives pancreatic carcinogenesis through plasma membrane Kras enrichment
· 2026 · Related
Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
· Jing Yang · 2023 · 386 citations · Cited by this paper
The metabolic fate of acetate in cancer
· Zachary T. Schug · 2016 · 350 citations · Cited by this paper
Acetyl-CoA metabolism in cancer
· David A. Guertin · 2023 · 305 citations · Cited by this paper
Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness
· Hongcheng Cheng · 2023 · 143 citations · Cited by this paper
Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc
· Juhong Wang · 2024 · 128 citations · Cited by this paper
Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies
· Luciano Nicosia · 2023 · 121 citations · Cited by this paper
High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate
· Peng Zhou · 2023 · 116 citations · Cited by this paper
Nutrient-driven histone code determines exhausted CD8 + T cell fates
· Shixin Ma · 2024 · 103 citations · Cited by this paper
Short-chain fatty acids and cancer
· Shan Li · 2024 · 102 citations · Cited by this paper
KAT6A Acetylation of SMAD3 Regulates Myeloid‐Derived Suppressor Cell Recruitment, Metastasis, and Immunotherapy in Triple‐Negative Breast Cancer
· Bo Yu · 2021 · 101 citations · Cited by this paper
Endothelial cell plasticity at the single-cell level
· Alessandra Pasut · 2021 · 100 citations · Cited by this paper
Interrogation of endothelial and mural cells in brain metastasis reveals key immune-regulatory mechanisms
· Leire Bejarano · 2024 · 91 citations · Cited by this paper
Fructose Metabolism in Tumor Endothelial Cells Promotes Angiogenesis by Activating AMPK Signaling and Mitochondrial Respiration
· Jian‐Hong Fang · 2023 · 67 citations · Cited by this paper
Profiling of syngeneic mouse HCC tumor models as a framework to understand anti–PD‐1 sensitive tumor microenvironments
· Daniel J. Zabransky · 2022 · 65 citations · Cited by this paper
MYC Overexpression Drives Immune Evasion in Hepatocellular Carcinoma That Is Reversible through Restoration of Proinflammatory Macrophages
· Renumathy Dhanasekaran · 2022 · 61 citations · Cited by this paper
Tumors resurrect an embryonic vascular program to escape immunity
· Elisabeth J. M. Huijbers · 2022 · 58 citations · Cited by this paper
5-Azacytidine Promotes an Inhibitory T-Cell Phenotype and Impairs Immune Mediated Antileukemic Activity
· Thomas Stübig · 2014 · 50 citations · Cited by this paper
Duvelisib plus romidepsin in relapsed/refractory T cell lymphomas: a phase 1b/2a trial
· Steven M. Horwitz · 2024 · 48 citations · Cited by this paper
The epigenetic hallmarks of immune cells in cancer
· Ji Hoon Yu · 2025 · 45 citations · Cited by this paper
Source: OpenAlex (CC0)