Research map: Methylophiopogonanone A mitigates myocardial ischemia–reperfusion injury: involvement of VEGFR2-associated PI3K/Akt/GSK-3β signaling and suppression of mPTP opening

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  1. Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions · Paolo Bernardi · 2023 · 457 citations · Cited by this paper
  2. Callistephus A from Callistephus chinensis alleviates DSS-induced ulcerative colitis and gut–liver axis disruption by targeting the JAK2/STAT1 pathway and remodeling gut microbiota · 2026 · Related
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  4. Guizhi Wuling Decoction alleviates myocardial fibrosis by restoring mitochondrial homeostasis: Evidence from network pharmacology, molecular docking, and multi-omics integration · 2026 · Related
  5. The role of PI3K/AKT signaling pathway in myocardial ischemia-reperfusion injury · Rui-ming Deng · 2023 · 194 citations · Cited by this paper
  6. Jiajian Shuyu Pills ameliorates cerebral ischemia-reperfusion injury by regulation hippo signaling and the lipid metabolism-ferroptosis axis · 2026 · Related
  7. The pathological mechanisms and potential therapeutic drugs for myocardial ischemia reperfusion injury · Shuo Zhang · 2024 · 143 citations · Cited by this paper
  8. CYP2C19-Mediated Metabolic Activation and OAT3/P-gp-Associated Transport Contribute to Dioscorea bulbifera L.-Induced Hepatotoxicity · 2026 · Related
  9. Platelet Contributions to Myocardial Ischemia/Reperfusion Injury · Nancy Schanze · 2019 · 102 citations · Cited by this paper
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  11. Cardioprotection of pharmacological postconditioning on myocardial ischemia/reperfusion injury · Yushi Wu · 2020 · 84 citations · Cited by this paper
  12. Embryotoxicity and teratogenicity of the aqueous extract of Cinnamomum verum in zebrafish (Danio rerio): a concentration-dependent developmental toxicity assessment · 2026 · Related
  13. The cardioprotective actions of statins in targeting mitochondrial dysfunction associated with myocardial ischaemia-reperfusion injury · Abigail R. Bland · 2021 · 81 citations · Cited by this paper
  14. Fermented Morinda citrifolia extract stimulates hair growth by promoting dermal papilla cell proliferation and modulating the follicular microenvironment · 2026 · Related
  15. Biomaterials-mediated targeted therapeutics of myocardial ischemia-reperfusion injury · Qiang Luo · 2023 · 61 citations · Cited by this paper
  16. Mulberry leaf flavonoids alleviate type 2 diabetes by remodeling the gut microbiota-bile acid axis and activating FXR signaling · 2026 · Related
  17. Panax ginseng against myocardial ischemia/reperfusion injury: A review of preclinical evidence and potential mechanisms · Jinjin Chen · 2022 · 48 citations · Cited by this paper
  18. Coixol attenuates Ulcerative Colitis by modulating the ILC3 response via the Wnt/β-catenin pathway · 2026 · Related
  19. Methylophiopogonanone A Protects against Cerebral Ischemia/Reperfusion Injury and Attenuates Blood-Brain Barrier Disruption In Vitro · Mingbao Lin · 2015 · 47 citations · Cited by this paper
  20. Germacrone mitigates cardiac remodeling by regulating PI3K/AKT-mediated oxidative stress, inflammation, and apoptosis · Zhao Fang · 2023 · 32 citations · Cited by this paper
  21. The VEGF/VEGFR2 system in ovarian cancer: From functional to pharmacological significance · Elisabetta Grillo · 2025 · 16 citations · Cited by this paper
  22. Endothelial ELABELA improves post-ischemic angiogenesis by upregulating VEGFR2 expression · Jiayu Peng · 2024 · 12 citations · Cited by this paper
  23. Progress in Chinese medicine monomers and their nanoformulations on myocardial ischemia/reperfusion injury · Yanrong Zhou · 2024 · 12 citations · Cited by this paper
  24. Myocardial Ischemia–Reperfusion Injury—Mechanistic Insights and Novel Therapeutics · Dong-Yeon Han · 2026 · 12 citations · Cited by this paper
  25. Blood flow patterns switch VEGFR2 activity through differential S-nitrosylation and S-oxidation · Dong Hoon Kang · 2023 · 10 citations · Cited by this paper
  26. Methylophiopogonanone A Inhibits Ferroptosis in H9c2 Cells: An Experimental and Molecular Simulation Study · Yanqing Wang · 2024 · 7 citations · Cited by this paper
  27. Predictive potential of various plasma inflammation-, angiogenesis-, and extracellular matrix remodeling-associated mediators for intra-amniotic inflammation and/or microbial invasion of the amniotic cavity in preterm labor · Eunwook Joo · 2024 · 6 citations · Cited by this paper
  28. Tanshinone IIA attenuates sepsis-induced lung injury by reducing VEGFR2/PI3K/AKT-driven mitochondrial disruption dependent apoptosis · Delida Aidebaike · 2025 · 6 citations · Cited by this paper
  29. PEDF inhibits VEGF-induced vascular leakage through binding to VEGFR2 in acute myocardial infarction · Hongliang Hui · 2024 · 5 citations · Cited by this paper
  30. Theaflavin-3,3′-digallate protects against myocardial ischemia/reperfusion injury and hypoxia/reoxygenation injury by activating the PI3K/Akt/mTOR pathway · Sha Wang · 2025 · 4 citations · Cited by this paper
  31. Detection assays of mitochondrial permeability transition pore: Current status and future prospects · Dongyang Hong · 2025 · 3 citations · Cited by this paper
  32. Human neutrophil-derived extracellular vesicles induce renal endothelial inflammation in critical illness: an ex vivo investigation · Jonny R. Stephens · 2025 · 3 citations · Cited by this paper
  33. Indobufen alleviates apoptosis by the PI3K/Akt/eNOS pathway in myocardial ischemia‒reperfusion (I/R) injury · Kai Hou · 2025 · 3 citations · Cited by this paper
  34. p16INK4a promotes myocardial ischemia-reperfusion injury by regulating bile acid transport via Slco1a4 · Tingting Yang · 2026 · 3 citations · Cited by this paper
  35. Methylophiopogonanone A alleviates diabetic cardiomyopathy via inhibiting JNK1 signaling · Jing Yin · 2025 · 2 citations · Cited by this paper
  36. Targeting Programmed Cell Death in Myocardial Ischemia–Reperfusion Injury: Potential Mechanisms and Natural Medicine Treatments · Xiaoyu Xuan · 2026 · 2 citations · Cited by this paper
  37. Methylophiopogonanone a attenuates pulmonary fibrosis by inhibiting SPP1 ‐mediated macrophage polarization via the PI3K /Akt pathway · F YANG · 2026 · 2 citations · Cited by this paper
  38. A Validated Liquid Chromatography–Tandem Mass Spectrometry Method for the Determination of Methylophiopogonanone A in Rat Plasma and Its Application to Pharmacokinetic Study · Tiantian Xie · 2024 · 1 citation · Cited by this paper
  39. CD44 N‐Glycosylation Alleviates Myocardial Ischemia–Reperfusion Through PI3K/AKT/mTOR Pathway · Yanxin Ren · 2026 · 1 citation · Cited by this paper

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