Research map: O-GlcNAc transferase as an oncogenic regulator in hematologic malignancies: Mechanisms, disease contexts, and therapeutic perspectives

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  1. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation · Matthew G. Vander Heiden · 2009 · 16528 citations · Cited by this paper
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  15. Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability · Won Ho Yang · 2006 · 485 citations · Cited by this paper
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  17. Structure of human O-GlcNAc transferase and its complex with a peptide substrate · Michael B. Lazarus · 2011 · 472 citations · Cited by this paper
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  19. c-Myc Is Glycosylated at Threonine 58, a Known Phosphorylation Site and a Mutational Hot Spot in Lymphomas · Teh‐Ying Chou · 1995 · 458 citations · Cited by this paper
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  22. β- N -acetylglucosamine (O-GlcNAc) is part of the histone code · Kaoru Sakabe · 2010 · 368 citations · Cited by this paper
  23. O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth · Hao Nie · 2020 · 367 citations · Cited by this paper
  24. GlcNAcylation of histone H2B facilitates its monoubiquitination · Ryoji Fujiki · 2011 · 330 citations · Cited by this paper
  25. A Small Molecule That Inhibits OGT Activity in Cells · Rodrigo F. Ortiz‐Meoz · 2015 · 307 citations · Cited by this paper
  26. The intersections betweenO-GlcNAcylation and phosphorylation: implications for multiple signaling pathways · Quira Zeidan · 2009 · 299 citations · Cited by this paper
  27. The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin α · Martin Jínek · 2004 · 294 citations · Cited by this paper
  28. O-GlcNAc Transferase Integrates Metabolic Pathways to Regulate the Stability of c-MYC in Human Prostate Cancer Cells · Harri M. Itkonen · 2013 · 291 citations · Cited by this paper
  29. O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling · Christina M. Ferrer · 2016 · 278 citations · Cited by this paper
  30. O-GlcNAc Transferase Catalyzes Site-Specific Proteolysis of HCF-1 · Francesca Capotosti · 2011 · 261 citations · Cited by this paper
  31. We're Not “DON” Yet: Optimal Dosing and Prodrug Delivery of6-Diazo-5-oxo-L-norleucine · Kathryn M. Lemberg · 2018 · 255 citations · Cited by this paper
  32. O-GlcNAcylation regulates EZH2 protein stability and function · Chi-Shuen Chu · 2014 · 237 citations · Cited by this paper
  33. The Hexosamine Biosynthesis Pathway: Regulation and Function · Alysta Paneque · 2023 · 228 citations · Cited by this paper
  34. Cross-talk between Two Essential Nutrient-sensitive Enzymes · John William Bullen · 2014 · 212 citations · Cited by this paper
  35. HCF-1 Is Cleaved in the Active Site of O-GlcNAc Transferase · Michael B. Lazarus · 2013 · 206 citations · Cited by this paper
  36. Regulation of Insulin Receptor Substrate 1 (IRS-1)/AKT Kinase-mediated Insulin Signaling by O-Linked β-N-Acetylglucosamine in 3T3-L1 Adipocytes · Stephen A. Whelan · 2009 · 182 citations · Cited by this paper
  37. The Nutrient-Sensing Hexosamine Biosynthetic Pathway as the Hub of Cancer Metabolic Rewiring · Ferdinando Chiaradonna · 2018 · 177 citations · Cited by this paper
  38. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors · Sara E. S. Martin · 2018 · 175 citations · Cited by this paper
  39. Ten-Eleven Translocation 1 (Tet1) Is Regulated by O-Linked N-Acetylglucosamine Transferase (Ogt) for Target Gene Repression in Mouse Embryonic Stem Cells · Feng-Tao Shi · 2013 · 165 citations · Cited by this paper

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