Research map: Deciphering the regulatory role of ADAM8 in the PDAC tumor microenvironment

Back to the article

Papers in this map

  1. Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer · Lauren J. Bayne · 2012 · 949 citations · Cited by this paper
  2. The ubiquitin-like protein FAT10 enhances the autophagy-mediated degradation of ZO-1 by stabilizing ATG3 to promote the lung metastasis of colon cancer · 2026 · Related
  3. Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment · Laura DeLong Wood · 2022 · 918 citations · Cited by this paper
  4. Reverse cardio-oncology: neuroendocrine axis activation and cardiovascular-disease-derived factors synergistically remodel the tumor microenvironment · 2026 · Related
  5. Tumor Microenvironment in Pancreatic Cancer Pathogenesis and Therapeutic Resistance · Mara H. Sherman · 2022 · 499 citations · Cited by this paper
  6. TFAP2A enhances radioresistance of non-small cell lung cancer by transcriptionally activating BRCA1 · 2026 · Related
  7. STAT3 Plays a Critical Role in KRAS -Induced Pancreatic Tumorigenesis · Ryan Bruce Corcoran · 2011 · 421 citations · Cited by this paper
  8. NAA50-mediated SLU7 stabilization promotes cisplatin resistance in bladder cancer via regulating MAP3K3 mRNA nuclear export and p38 MAPK activation · 2026 · Related
  9. GM-CSF: A Double-Edged Sword in Cancer Immunotherapy · Anil Kumar · 2022 · 272 citations · Cited by this paper
  10. Lactylation shields S100A11 from degradation to promote gastric cancer metastasis · 2026 · Related
  11. Mutant KRAS–Induced Expression of ICAM-1 in Pancreatic Acinar Cells Causes Attraction of Macrophages to Expedite the Formation of Precancerous Lesions · Geou‐Yarh Liou · 2014 · 211 citations · Cited by this paper
  12. RNF114-PACSIN3 signaling axis promotes hepatocellular carcinoma progression by enhancing GLUT1 membrane retention and glucose uptake · 2026 · Related
  13. Inflammatory networks and immune surveillance of pancreatic carcinoma · Robert H. Vonderheide · 2013 · 211 citations · Cited by this paper
  14. Cis-3-hexen-1-ol suppresses bladder cancer progression by inducing mitophagy via the PCK2/AMPK/mTOR signaling pathway · 2026 · Related
  15. Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer Progression · Damya Laoui · 2014 · 206 citations · Cited by this paper
  16. Inhibition of DLX6 sensitizes lung adenocarcinoma to cisplatin via GPX4-dependent ferroptosis · 2026 · Related
  17. The Metalloprotease Disintegrin ADAM8 · Uwe Schlomann · 2002 · 173 citations · Cited by this paper
  18. Tumor lymph node metastasis chip reveals that the NECTIN3-TIGIT axis promotes melanoma metastasis by enhancing treg cell function and inducing CD8+ T cell exhaustion · 2026 · Related
  19. A role of GM-CSF in the accumulation of neutrophils in the airways caused by IL-17 and TNF‐α · Martti Laan · 2003 · 148 citations · Cited by this paper
  20. Targeting PRMT5 to reshape the immune microenvironment and reverse Trop2 ADC resistance in triple-negative breast cancer · 2026 · Related
  21. Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer · Anna Bianchi · 2023 · 136 citations · Cited by this paper
  22. FAK and paxillin, two potential targets in pancreatic cancer · Rajani Kanteti · 2016 · 130 citations · Cited by this paper
  23. ADAM8 as a drug target in pancreatic cancer · Uwe Schlomann · 2015 · 128 citations · Cited by this paper
  24. Metalloprotease‐disintegrin ADAM8: Expression analysis and targeted deletion in mice · Kristine A. Kelly · 2004 · 121 citations · Cited by this paper
  25. Crosstalk between Tumor and Stromal Cells in Pancreatic Ductal Adenocarcinoma · Nadine Sperb · 2020 · 108 citations · Cited by this paper
  26. GM‐CSF promotes migration of human monocytes across the blood brain barrier · Daphne Y.S. Vogel · 2015 · 99 citations · Cited by this paper
  27. ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer · Nataliya Valkovskaya · 2007 · 93 citations · Cited by this paper
  28. The reciprocal regulation between host tissue and immune cells in pancreatic ductal adenocarcinoma: new insights and therapeutic implications · Xiaomeng Liu · 2019 · 84 citations · Cited by this paper
  29. TNF-α promotes a stop signal that inhibits neutrophil polarization and migration via a p38 MAPK pathway · Mary A. Lokuta · 2005 · 74 citations · Cited by this paper
  30. Tissue engineering the cancer microenvironment—challenges and opportunities · Vassilis Papalazarou · 2018 · 64 citations · Cited by this paper
  31. ADAM8 signaling drives neutrophil migration and ARDS severity · Catharina Conrad · 2022 · 62 citations · Cited by this paper
  32. Functional roles of SRC signaling in pancreatic cancer: Recent insights provide novel therapeutic opportunities · Ashleigh R. Poh · 2023 · 53 citations · Cited by this paper
  33. Enhancement of ICAM-1 via the JAK2/STAT3 signaling pathway in a rat model of severe acute pancreatitis-associated lung injury · Xiao Han · 2016 · 42 citations · Cited by this paper
  34. Macrophage colony-stimulating factor and its role in the tumor microenvironment: novel therapeutic avenues and mechanistic insights · Yi Li · 2024 · 32 citations · Cited by this paper
  35. ADAM8-Dependent Extracellular Signaling in the Tumor Microenvironment Involves Regulated Release of Lipocalin 2 and MMP-9 · Lena Cook · 2022 · 21 citations · Cited by this paper
  36. The GBM Tumor Microenvironment as a Modulator of Therapy Response: ADAM8 Causes Tumor Infiltration of Tams through HB-EGF/EGFR-Mediated CCL2 Expression and Overcomes TMZ Chemosensitization in Glioblastoma · Xiaojin Liu · 2022 · 21 citations · Cited by this paper
  37. Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy · Kendelle Joan Murphy · 2022 · 19 citations · Cited by this paper
  38. Cohort Analysis of ADAM8 Expression in the PDAC Tumor Stroma · Christian Peter Jaworek · 2021 · 17 citations · Cited by this paper
  39. Blockade of the ADAM8-Fra-1 complex attenuates neuroinflammation by suppressing the Map3k4/MAPKs axis after spinal cord injury · Zhanyang Qian · 2024 · 17 citations · Cited by this paper

Source: OpenAlex (CC0)