Research map: Imeglimin Attenuates Skeletal Muscle Atrophy in Mouse Models of Obesity and Ageing

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  1. Guidelines for assessment of bone microstructure in rodents using micro–computed tomography · Mary Bouxsein · 2010 · 4575 citations · Cited by this paper
  2. Comment on ‘Effect of Skeletal Muscle Mass and Its Associated Mediators on the Development of Steatotic Liver Disease: A Cohort Study in China’ by Liang et al. · 2026 · Related
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  9. Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial · William T. Cefalu · 2013 · 732 citations · Cited by this paper
  10. Deletion of Tgf‐β1 From CD206 + M2 Macrophages Ameliorates Obesity‐Induced Suppression of Myogenesis and AMPK Phosphorylation in Skeletal Muscle · 2026 · Related
  11. NF-kB and Inflammatory Cytokine Signalling: Role in Skeletal Muscle Atrophy · Anastasia Thoma · 2018 · 317 citations · Cited by this paper
  12. RIPK3 Inhibition Mitigates Denervated Muscle Atrophy via NOX4‐Mediated Mitochondrial Restoration and Inflammation Suppression · 2026 · Related
  13. A Review of the Effects of Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors on Lean Body Mass in Humans · Jack Alistair Sargeant · 2019 · 227 citations · Cited by this paper
  14. Improving Hip Fracture Prediction by Using Sarcopenia‐Specific Cut‐Offs of T‐Scores for Osteosarcopenia: A Prospective Cohort Study · 2026 · Related
  15. Multimodal cell atlas of the ageing human skeletal muscle · Yiwei Lai · 2024 · 202 citations · Cited by this paper
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  17. Mechanism of action of Imeglimin: A novel therapeutic agent for type 2 diabetes · Sophie Hallakou‐Bozec · 2020 · 197 citations · Cited by this paper
  18. Combined Effect of Sarcopenia and Impaired Respiratory Function on All‐Cause Death: A Nationwide Cohort Study · 2026 · Related
  19. Imeglimin Normalizes Glucose Tolerance and Insulin Sensitivity and Improves Mitochondrial Function in Liver of a High-Fat, High-Sucrose Diet Mice Model · Guillaume Vial · 2014 · 196 citations · Cited by this paper
  20. Cancer IDO1‐Mediated Tryptophan–Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration · 2026 · Related
  21. Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss · Philip F. Dobson · 2020 · 174 citations · Cited by this paper
  22. Sarcopenia: Molecular Pathways and Potential Targets for Intervention · Jorge Pascual-Fernández · 2020 · 128 citations · Cited by this paper
  23. Imeglimin, a novel glimin oral antidiabetic, exhibits a good efficacy and safety profile in type 2 diabetic patients · Valdis Pīrāgs · 2012 · 123 citations · Cited by this paper
  24. TNF-α contributes to sarcopenia through caspase-8/caspase-3/GSDME-mediated pyroptosis · Jingying Wu · 2023 · 113 citations · Cited by this paper
  25. Efficacy and Safety of Imeglimin Monotherapy Versus Placebo in Japanese Patients With Type 2 Diabetes (TIMES 1): A Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, Multicenter Phase 3 Trial · Julie Dubourg · 2021 · 111 citations · Cited by this paper
  26. Long‐term safety and efficacy of imeglimin as monotherapy or in combination with existing antidiabetic agents in Japanese patients with type 2 diabetes ( TIMES 2): A 52‐week, open‐label, multicentre phase 3 trial · Julie Dubourg · 2021 · 104 citations · Cited by this paper
  27. PAI-1, the Plasminogen System, and Skeletal Muscle · Fasih Ahmad Rahman · 2020 · 90 citations · Cited by this paper
  28. Resveratrol Ameliorates Palmitate-Induced Inflammation in Skeletal Muscle Cells by Attenuating Oxidative Stress and JNK/NF-κB Pathway in a SIRT1-Independent Mechanism · Asie Sadeghi · 2017 · 89 citations · Cited by this paper
  29. Regulation of fos and jun immediate-early genes by redox or metabolic stress in cardiac myocytes. · Keith A. Webster · 1994 · 84 citations · Cited by this paper
  30. The Efficacy and Safety of Imeglimin as Add-on Therapy in Patients With Type 2 Diabetes Inadequately Controlled With Sitagliptin Monotherapy · Pascale Fouqueray · 2014 · 81 citations · Cited by this paper
  31. Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice · Takayoshi Sasako · 2022 · 81 citations · Cited by this paper
  32. Effect of sodium-glucose transporter 2 inhibitors on sarcopenia in patients with type 2 diabetes mellitus: a systematic review and meta-analysis · Sha Zhang · 2023 · 81 citations · Cited by this paper
  33. Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway · Jinghe Li · 2021 · 77 citations · Cited by this paper
  34. Impact of GLP- 1 Receptor Agonist Therapy in Patients High Risk for Sarcopenia · Zoe Nicole Memel · 2025 · 61 citations · Cited by this paper
  35. Type 2 diabetes mellitus related sarcopenia: a type of muscle loss distinct from sarcopenia and disuse muscle atrophy · Zhenchao Liu · 2024 · 49 citations · Cited by this paper
  36. Metformin and physical performance in older people with probable sarcopenia and physical prefrailty or frailty in England (MET-PREVENT): a double-blind, randomised, placebo-controlled trial · Miles D. Witham · 2025 · 42 citations · Cited by this paper
  37. Mitochondrial dysfunction in age-related sarcopenia: mechanistic insights, diagnostic advances, and therapeutic prospects · Yingtao Huang · 2025 · 41 citations · Cited by this paper
  38. Thrown for a loop: fibro-adipogenic progenitors in skeletal muscle fibrosis · Taryn Loomis · 2023 · 38 citations · Cited by this paper
  39. Effects of age on human skeletal muscle: a systematic review and meta-analysis of myosin heavy chain isoform protein expression, fiber size, and distribution · Christopher Lee · 2024 · 35 citations · Cited by this paper

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