Research map: When defense backfires: inflammatory determinants of RSV-induced disease severity

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  1. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells · Estelle Bettelli · 2006 · 7030 citations · Cited by this paper
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  13. Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice. · Barney S. Graham · 1991 · 509 citations · Cited by this paper
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  15. Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus. · Martin J. Cannon · 1988 · 463 citations · Cited by this paper
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  19. Suppression of the Induction of Alpha, Beta, and Gamma Interferons by the NS1 and NS2 Proteins of Human Respiratory Syncytial Virus in Human Epithelial Cells and Macrophages · Kirsten M. Spann · 2004 · 449 citations · Cited by this paper
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  22. Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro : Clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant · Ruth A. Karron · 1997 · 422 citations · Cited by this paper
  23. The Human Immune Response to Respiratory Syncytial Virus Infection · Clark D Russell · 2017 · 420 citations · Cited by this paper
  24. Retinoic Acid-Inducible Gene I Mediates Early Antiviral Response and Toll-Like Receptor 3 Expression in Respiratory Syncytial Virus-Infected Airway Epithelial Cells · Ping Liu · 2006 · 323 citations · Cited by this paper
  25. Vitamin D Decreases Respiratory Syncytial Virus Induction of NF-κB–Linked Chemokines and Cytokines in Airway Epithelium While Maintaining the Antiviral State · Sif Hansdóttir · 2009 · 318 citations · Cited by this paper
  26. RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection · Agnieszka Jóźwik · 2015 · 307 citations · Cited by this paper
  27. Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology · Tracy Hussell · 2001 · 286 citations · Cited by this paper
  28. Differential Role for TLR3 in Respiratory Syncytial Virus-Induced Chemokine Expression · Brian D. Rudd · 2005 · 274 citations · Cited by this paper
  29. Respiratory syncytial virus infection during infancy and asthma during childhood in the USA (INSPIRE): a population-based, prospective birth cohort study · Christian Rosas‐Salazar · 2023 · 266 citations · Cited by this paper
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  31. Foxp3+ CD4 Regulatory T Cells Limit Pulmonary Immunopathology by Modulating the CD8 T Cell Response during Respiratory Syncytial Virus Infection · Ross Bane Fulton · 2010 · 252 citations · Cited by this paper
  32. IL-17–Induced Pulmonary Pathogenesis during Respiratory Viral Infection and Exacerbation of Allergic Disease · Sumanta Mukherjee · 2011 · 245 citations · Cited by this paper
  33. TLR2/MyD88/NF-κB Pathway, Reactive Oxygen Species, Potassium Efflux Activates NLRP3/ASC Inflammasome during Respiratory Syncytial Virus Infection · Jesus A. Segovia · 2012 · 243 citations · Cited by this paper
  34. Human Respiratory Syncytial Virus Nonstructural Protein NS2 Antagonizes the Activation of Beta Interferon Transcription by Interacting with RIG-I · Zhenhua Ling · 2009 · 234 citations · Cited by this paper
  35. Respiratory syncytial virus (RSV) evades the human adaptive immune system by skewing the Th1/Th2 cytokine balance toward increased levels of Th2 cytokines and IgE, markers of allergy—a review · Yechiel Becker · 2006 · 208 citations · Cited by this paper
  36. Mortality Attributable to 9 Common Infections: Significant Effect of Influenza A, Respiratory Syncytial Virus, Influenza B, Norovirus, and Parainfluenza in Elderly Persons · Liselotte van Asten · 2012 · 200 citations · Cited by this paper
  37. Induction of NFATc2 Expression by Interleukin 6 Promotes T Helper Type 2 Differentiation · Sean A. Diehl · 2002 · 198 citations · Cited by this paper
  38. Respiratory syncytial virus infection activates IL-13–producing group 2 innate lymphoid cells through thymic stromal lymphopoietin · Matthew T. Stier · 2016 · 195 citations · Cited by this paper
  39. Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection · Maximillian S. Habibi · 2020 · 193 citations · Cited by this paper

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