Research map: Matrix Competence Failure in Osteoporosis: Mechanosensing, Osteoimmune Crosstalk, and Fragility Beyond Bone Mineral Density

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  1. Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases · Claudio Franceschi · 2014 · 3945 citations · Cited by this paper
  2. Peptide Loading Complex in Cancer: From Peptide Translocation, Editing, and Loading into MHC-I to a Potential Therapeutic Target · 2026 · Related
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  5. Romosozumab Treatment in Postmenopausal Women with Osteoporosis · Felicia Cosman · 2016 · 1811 citations · Cited by this paper
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  8. Predictive Value of Admission Renal Injury-Related Indicators for Fatal Outcomes in Patients with Severe Fever with Thrombocytopenia Syndrome · 2026 · Related
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  11. Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin · Alexander G. Robling · 2007 · 1360 citations · Cited by this paper
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  13. Mesenchymal stem cell-macrophage crosstalk and bone healing · Jukka Pajarinen · 2018 · 1044 citations · Cited by this paper
  14. Trehalose: A Promising Therapeutic Agent for Diverse Pathological Conditions · 2026 · Related
  15. Inflammaging and ‘Garb-aging’ · Claudio Franceschi · 2016 · 1025 citations · Cited by this paper
  16. Strategies for Evading Cellular Immunity Against Recombinant AAV Vectors in Gene Therapy · 2026 · Related
  17. Distinct fibroblast subsets drive inflammation and damage in arthritis · Adam P. Croft · 2019 · 1015 citations · Cited by this paper
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  19. Targeted Ablation of Osteocytes Induces Osteoporosis with Defective Mechanotransduction · Sawako Tatsumi · 2007 · 848 citations · Cited by this paper
  20. Serum and bone pentosidine in patients with low impact hip fractures and in patients with advanced osteoarthritis · 2016 · Related
  21. Cell–extracellular matrix mechanotransduction in 3D · Aashrith Saraswathibhatla · 2023 · 820 citations · Cited by this paper
  22. Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts · Kevin P. McHugh · 2000 · 735 citations · Cited by this paper
  23. Immunosenescence and inflammaging in the aging process: age-related diseases or longevity? · Aurelia Santoro · 2021 · 610 citations · Cited by this paper
  24. Bone metastases · Robert Edward Coleman · 2020 · 585 citations · Cited by this paper
  25. Identification of Senescent Cells in the Bone Microenvironment · Joshua N. Farr · 2016 · 568 citations · Cited by this paper
  26. Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis · Wenhui Hu · 2020 · 522 citations · Cited by this paper
  27. Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation · Hai Qing · 2012 · 499 citations · Cited by this paper
  28. Bone fragility in diabetes: novel concepts and clinical implications · Lorenz Christian Hofbauer · 2022 · 442 citations · Cited by this paper
  29. Ageing and rejuvenation of tissue stem cells and their niches · Anne Sophie Brunet · 2022 · 413 citations · Cited by this paper
  30. The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation · Leandro Moretti · 2021 · 396 citations · Cited by this paper
  31. Determinants of Muscle and Bone Aging · Elizabeth Mary Curtis · 2015 · 388 citations · Cited by this paper
  32. The Effects of Twelve Weeks of Bed Rest on Bone Histology, Biochemical Markers of Bone Turnover, and Calcium Homeostasis in Eleven Normal Subjects · Joseph E. Zerwekh · 1998 · 380 citations · Cited by this paper
  33. Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading · Lidan You · 2007 · 362 citations · Cited by this paper
  34. Substrate Deformation Levels Associated With Routine Physical Activity Are Less Stimulatory to Bone Cells Relative to Loading-Induced Oscillatory Fluid Flow · Jiangfeng You · 2000 · 360 citations · Cited by this paper
  35. The role of matrix metalloproteinases in aging: Tissue remodeling and beyond · Sandra Freitas‐Rodríguez · 2017 · 360 citations · Cited by this paper
  36. Bone progenitor cell deficits and the age-associated decline in bone repair capacity · Rodolfo Quarto · 1995 · 349 citations · Cited by this paper
  37. Bone Loss and Muscle Atrophy in Spinal Cord Injury: Epidemiology, Fracture Prediction, and Rehabilitation Strategies · Lora Giangregorio · 2006 · 334 citations · Cited by this paper
  38. Increased Sclerostin Serum Levels Associated with Bone Formation and Resorption Markers in Patients with Immobilization-Induced Bone Loss · Agostino Gaudio · 2010 · 315 citations · Cited by this paper
  39. Bone Microenvironment and Osteosarcoma Metastasis · Chaofei Yang · 2020 · 313 citations · Cited by this paper

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