Research map: Exploring the rationale for upfront corticosteroid–JAK inhibitor combination therapy in acute severe ulcerative colitis

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Papers in this map

  1. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice · Isao Okayasu · 1990 · 2433 citations · Cited by this paper
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  5. Interleukin-13 Is the Key Effector Th2 Cytokine in Ulcerative Colitis That Affects Epithelial Tight Junctions, Apoptosis, and Cell Restitution · FRANK A. HELLER · 2005 · 1112 citations · Cited by this paper
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  9. Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial · David Laharie · 2012 · 652 citations · Cited by this paper
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  11. A randomised dose finding study of oral tacrolimus (FK506) therapy in refractory ulcerative colitis · Hisao Ogata · 2006 · 463 citations · Cited by this paper
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  13. Regulation of JNK and p38 MAPK in the immune system: Signal integration, propagation and termination · Gonghua Huang · 2009 · 371 citations · Cited by this paper
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  17. Infliximab versus ciclosporin for steroid-resistant acute severe ulcerative colitis (CONSTRUCT): a mixed methods, open-label, pragmatic randomised trial · John Gordon Williams · 2016 · 270 citations · Cited by this paper
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  19. JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions · Alexey Sarapultsev · 2023 · 219 citations · Cited by this paper
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  21. Acute severe ulcerative colitis: from pathophysiology to clinical management · Pieter Hindryckx · 2016 · 191 citations · Cited by this paper
  22. The selective nonpeptide CXCR2 antagonist SB225002 ameliorates acute experimental colitis in mice · Allisson Freire Bento · 2008 · 140 citations · Cited by this paper
  23. Tofacitinib for Biologic-Experienced Hospitalized Patients With Acute Severe Ulcerative Colitis: A Retrospective Case-Control Study · Jeffrey Aaron Berinstein · 2021 · 140 citations · Cited by this paper
  24. Role of STAT3 in inflammatory bowel disease · Ken Sugimoto · 2008 · 131 citations · Cited by this paper
  25. The current state of the art for biological therapies and new small molecules in inflammatory bowel disease · Sudarshan Paramsothy · 2018 · 116 citations · Cited by this paper
  26. Tofacitinib in Acute Severe Ulcerative Colitis (TACOS): A Randomized Controlled Trial · Arshdeep Singh · 2023 · 112 citations · Cited by this paper
  27. Efficacy of Induction Therapy With High-Intensity Tofacitinib in 4 Patients With Acute Severe Ulcerative Colitis · Jeffrey Aaron Berinstein · 2018 · 108 citations · Cited by this paper
  28. Acute severe ulcerative colitis trials: the past, the present and the future · Sailish Honap · 2024 · 76 citations · Cited by this paper
  29. Acute severe ulcerative colitis management: unanswered questions and latest insights · Pauline Rivière · 2024 · 66 citations · Cited by this paper
  30. Long‐term outcomes of acute severe ulcerative colitis in the rescue therapy era: A multicentre cohort study · Stefano Festa · 2020 · 54 citations · Cited by this paper
  31. Effectiveness of Upadacitinib for Patients With Acute Severe Ulcerative Colitis: A Multicenter Experience · Jeffrey Aaron Berinstein · 2024 · 54 citations · Cited by this paper
  32. Neutrophil Extracellular Traps Exacerbate Inflammatory Responses and Thrombotic Tendency in Both a Murine Colitis Model and Patients with Inflammatory Bowel Disease · Muhua Cao · 2017 · 30 citations · Cited by this paper
  33. Top-down infliximab plus azathioprine versus azathioprine alone in patients with acute severe ulcerative colitis responsive to intravenous steroids: a parallel, open-label randomised controlled trial, the ACTIVE trial · Aurélien Amiot · 2024 · 25 citations · Cited by this paper
  34. Combination therapy with biologics and/or small molecules in inflammatory bowel disease: a comprehensive review · Javier P. Gisbert · 2025 · 17 citations · Cited by this paper
  35. The evolving role of JAK inhibitors in the treatment of inflammatory bowel disease · Nancy Gupta · 2023 · 10 citations · Cited by this paper
  36. Intravenous tacrolimus is a superior induction therapy for acute severe ulcerative colitis compared to oral tacrolimus · Hiromichi Shimizu · 2021 · 7 citations · Cited by this paper
  37. Azathioprine or Tofacitinib as Maintenance Therapy in Corticosteroid‐Responsive Acute Severe Ulcerative Colitis · Arshdeep Singh · 2025 · 5 citations · Cited by this paper
  38. P681 Effectiveness and safety of oral Tacrolimus salvage therapy for acute severe ulcerative colitis: a retrospective study · Natalie Tamir‐Degabli · 2023 · 2 citations · Cited by this paper
  39. Corticosteroids combined with infliximab vs. corticosteroids sequential infliximab for acute severe ulcerative colitis with mucosal deficiency: a retrospective study · Xiaolei Liu · 2024 · 1 citation · Cited by this paper

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