Research map: Genomic, epigenomic and transcriptomic regulation of cellular senescence

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  1. The serial cultivation of human diploid cell strains · Leonard Hayflick · 1961 · 8556 citations · Cited by this paper
  2. The emerging role of aging in tumorigenesis · Xiaofen Wu · 2026 · Cites this paper
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  6. p53, guardian of the genome · David Philip Lane · 1992 · 5169 citations · Cited by this paper
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  8. Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a · Manuel Serrano · 1997 · 5163 citations · Cited by this paper
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  10. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders · Darren J. Baker · 2011 · 3748 citations · Cited by this paper
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  12. Cellular Senescence: Defining a Path Forward · Vassilis G. Gorgoulis · 2019 · 3338 citations · Cited by this paper
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  14. Naturally occurring p16Ink4a-positive cells shorten healthy lifespan · Darren J. Baker · 2016 · 2881 citations · Cited by this paper
  15. Genetic analysis of imaging-derived phenotypes · 2026 · Related
  16. The role of senescent cells in ageing · Jan M. van Deursen · 2014 · 2695 citations · Cited by this paper
  17. Transposable elements as catalysts of evolutionary innovation · 2026 · Related
  18. Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence · Masashi Narita · 2003 · 2279 citations · Cited by this paper
  19. Mechanisms of DNA specificity in chromatin remodelling · 2026 · Related
  20. Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins · Rumani Singh · 2019 · 2142 citations · Cited by this paper
  21. Navigating ethical, legal and social implications in genomic newborn screening · 2026 · Related
  22. An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA · Marco Demaria · 2014 · 2080 citations · Cited by this paper
  23. Autophagy maintains stemness by preventing senescence · Laura García‐Prat · 2016 · 1397 citations · Cited by this paper
  24. Cytoplasmic chromatin triggers inflammation in senescence and cancer · Zhixun Dou · 2017 · 1357 citations · Cited by this paper
  25. L1 drives IFN in senescent cells and promotes age-associated inflammation · Marco De Cecco · 2019 · 1317 citations · Cited by this paper
  26. Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype · Christopher D. Wiley · 2015 · 1280 citations · Cited by this paper
  27. Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence · Selene Glück · 2017 · 1214 citations · Cited by this paper
  28. Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning · Mekayla A. Storer · 2013 · 1203 citations · Cited by this paper
  29. Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors · Yi Zhun Zhu · 2015 · 1165 citations · Cited by this paper
  30. Lamin B1 loss is a senescence-associated biomarker · Adam Freund · 2012 · 1073 citations · Cited by this paper
  31. p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype · Adam Freund · 2011 · 1061 citations · Cited by this paper
  32. A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues · Dominik Saul · 2022 · 1051 citations · Cited by this paper
  33. Feedback between p21 and reactive oxygen production is necessary for cell senescence · João F. Passos · 2010 · 1035 citations · Cited by this paper
  34. Geriatric muscle stem cells switch reversible quiescence into senescence · Pedro Sousa‐Victor · 2014 · 1021 citations · Cited by this paper
  35. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts · David A. Alcorta · 1996 · 997 citations · Cited by this paper
  36. Senescence and apoptosis: dueling or complementary cell fates? · Bennett G. Childs · 2014 · 927 citations · Cited by this paper
  37. Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human Fibroblasts · Gretchen H. Stein · 1999 · 878 citations · Cited by this paper
  38. The senescence-associated secretory phenotype and its physiological and pathological implications · Boshi Wang · 2024 · 871 citations · Cited by this paper
  39. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation · Marzia Fumagalli · 2012 · 861 citations · Cited by this paper

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