Research map: Discovery of Thienopyrimidine Analog G-18 as a Novel Anti-Trichomonal Agent

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  1. Metronidazole: an update on metabolism, structure–cytotoxicity and resistance mechanisms · Simon A. Dingsdag · 2017 · 422 citations · Cited by this paper
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  11. In Vitro Drug Susceptibility and Doses of Metronidazole Required for Cure in Cases of Refractory Vaginal Trichomoniasis · Joseph G. Lossick · 1986 · 144 citations · Cited by this paper
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  13. Molecular basis of metronidazole resistance in pathogenic bacteria and protozoa · Kirkwood M. Land · 1999 · 95 citations · Cited by this paper
  14. Impact of cyst maturity on drug resistance assays in Acanthamoeba Genotype T4 · 2026 · Related
  15. A systematic review of the literature on mechanisms of 5-nitroimidazole resistance inTrichomonas vaginalis · Keonte J. Graves · 2020 · 78 citations · Cited by this paper
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  17. Deazapurine Nucleoside Analogues for the Treatment of Trichomonas vaginalis · Manal J. Natto · 2021 · 46 citations · Cited by this paper
  18. Mechanistic, in-silico and in vitro studies with nitrofurans reveal potent leishmanicidal activity and inhibition of trypanothione reductase · 2025 · Related
  19. Auranofin inactivates Trichomonas vaginalis thioredoxin reductase and is effective against trichomonads in vitro and in vivo · Melissa J. Hopper · 2016 · 44 citations · Cited by this paper
  20. Potentiating Metronidazole Scaffold against Resistant Trichomonas: Design, Synthesis, Biology and 3D–QSAR Analysis · Lalit Kumar · 2011 · 42 citations · Cited by this paper
  21. 20S Proteasome as a Drug Target in Trichomonas vaginalis · Anthony John O’Donoghue · 2019 · 39 citations · Cited by this paper
  22. Murine Models of Vaginal Trichomonad Infections · Eduardo Ruben Cobo · 2011 · 35 citations · Cited by this paper
  23. Prevalence and metronidazole resistance of Trichomonas vaginalis among Japanese women in 2021 · Yumiko Saito‐Nakano · 2023 · 24 citations · Cited by this paper
  24. Antiparasitic activity of furanyl N-acylhydrazone derivatives against Trichomonas vaginalis: in vitro and in silico analyses · Mirna Samara Dié Alves · 2020 · 21 citations · Cited by this paper
  25. Formation and Identification of Two Hydroxmethylfurfural–Glycine Adducts and Their Cytotoxicity and Absorption in Caco-2 Cells · Rui Zeng · 2019 · 16 citations · Cited by this paper
  26. 'IN VITRO' STUDY OF CHEMOTHERAPEUTIC ACTIVITY OF SULPHIMIDAZOLE ON SOME SENSITIVE AND METRONIDAZOLE-RESISTANT Trichomonas vaginalis STRAINS · Marcella Malagoli · 2002 · 14 citations · Cited by this paper
  27. In Vitro Testing of Trichomonas vaginalis Drug Susceptibility: Evaluation of Minimal Lethal Concentrations for Metronidazole and Tinidazole That Correspond With Treatment Failure · Peter Augostini · 2023 · 14 citations · Cited by this paper
  28. Chlorinated metronidazole as a promising alternative for treating trichomoniasis · Michelle Oliveira Chacon · 2018 · 13 citations · Cited by this paper
  29. Potential of bisbenzimidazole‐analogs toward metronidazole‐resistant Trichomonas vaginalis isolates · Travis C. Korosh · 2017 · 12 citations · Cited by this paper
  30. Comparative proteomic analysis of metronidazole-sensitive and resistant Trichomonas vaginalis suggests a novel mode of metronidazole action and resistance · Anna-Lena Mayr · 2024 · 10 citations · Cited by this paper
  31. Evaluation of the mechanism of action of albendazole on adult rat lungworm (Angiostrongylus cantonensis) · John Prasanth Jacob · 2022 · 10 citations · Cited by this paper
  32. Flow-cytometry-based physiological characterisation and transcriptome analyses reveal a mechanism for reduced cell viability in yeast engineered for increased lipid content · Huadong Peng · 2019 · 8 citations · Cited by this paper
  33. Transcriptional profile of Trichomonas vaginalis in response to metronidazole · Yiting Xie · 2023 · 8 citations · Cited by this paper
  34. Cytotoxicity and detection of damage to DNA by 3-(5-nitro-2-thienyl)-9-chloro-5-morpholin-4-yl[1,2,4]triazolo[4,3-c] quinazoline on human cancer cell line HeLa · Renáta Ovádeková · 2005 · 7 citations · Cited by this paper
  35. In vitro and in silico trichomonacidal activity of 2,8-bis(trifluoromethyl) quinoline analogs against Trichomonas vaginalis · Mirna Samara Dié Alves · 2022 · 6 citations · Cited by this paper
  36. Metronidazole Chemotherapy for Trichomonas Vaginalis Infections · Paulita Sikat · 1962 · 4 citations · Cited by this paper
  37. Small Molecular Drug Screening Based on Clinical Therapeutic Effect · Zhonghua Cai · 2022 · 4 citations · Cited by this paper
  38. Using Bland–Altman Analysis to Identify Appropriate Clonogenic Assay Colony Counting Techniques · Seth M. Buryska · 2023 · 3 citations · Cited by this paper
  39. Clinical Characteristics of Vaginal Trichomoniasis Infection and Metronidazole Resistance in Vaginitis Patients · Guangxin Lv · 2025 · 1 citation · Cited by this paper

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