Research map: Investigating gut microbiota and their metabolites as biomarkers for tacrolimus pharmacokinetic variability

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  1. Host-Gut Microbiota Metabolic Interactions · Jeremy Kirk Nicholson · 2012 · 4848 citations · Cited by this paper
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  17. Personalized Mapping of Drug Metabolism by the Human Gut Microbiome · Bahar Javdan · 2020 · 496 citations · Cited by this paper
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  19. Evolution of virulence in Enterococcus faecium, a hospital-adapted opportunistic pathogen · Wei Gao · 2017 · 263 citations · Cited by this paper
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  23. Human Microbiota Characterization in the Course of Renal Transplantation · W. Florian Fricke · 2013 · 180 citations · Cited by this paper
  24. Clinical determinants of calcineurin inhibitor disposition: a mechanistic review · Thomas Vanhove · 2016 · 175 citations · Cited by this paper
  25. Commensal Gut Bacteria Convert the Immunosuppressant Tacrolimus to Less Potent Metabolites · Yukuang Guo · 2018 · 162 citations · Cited by this paper
  26. Enterococcus faecium: evolution, adaptation, pathogenesis and emerging therapeutics · Yahan Wei · 2024 · 139 citations · Cited by this paper
  27. Cytochrome P450 3A4 and P-glycoprotein Activity and Assimilation of Tacrolimus in Transplant Patients with Persistent Diarrhea · Wim P.D. Lemahieu · 2005 · 133 citations · Cited by this paper
  28. Overview of Immunosuppressive Therapy in Solid Organ Transplantation · Curtis Holt · 2017 · 121 citations · Cited by this paper
  29. A comprehensive review of the impact of tacrolimus intrapatient variability on clinical outcomes in kidney transplantation · Haley M. Gonzales · 2020 · 102 citations · Cited by this paper
  30. Characterizing the Expression of CYP3A4 and Efflux Transporters (P-gp, MRP1, and MRP2) in CYP3A4-Transfected Caco-2 Cells After Induction with Sodium Butyrate and the Phorbol Ester 12-O-Tetradecanoylphorbol-13-Acetate · Carolyn L. Cummins · 2001 · 94 citations · Cited by this paper
  31. Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1 · Alexandra Louise Degraeve · 2023 · 72 citations · Cited by this paper
  32. Differential Effect of Diarrhea on FK506 Versus Cyclosporine A Trough Levels and Resultant Prevention of Allograft Rejection in Renal Transplant Recipients · Bart Maes · 2002 · 67 citations · Cited by this paper
  33. Short-chain fatty acids exert opposite effects on the expression and function of p-glycoprotein and breast cancer resistance protein in rat intestine · Qiushi Xie · 2020 · 66 citations · Cited by this paper
  34. Pharmacokinetic Interaction between Levofloxacin and Ciclosporin or Tacrolimus in Kidney Transplant Recipients · Stefano Federico · 2006 · 51 citations · Cited by this paper
  35. Integrating the gut microbiome and pharmacology · Andrew A Verdegaal · 2024 · 51 citations · Cited by this paper
  36. Variable effects of sodium butyrate on the expression and function of the MDR 1 (P‐glycoprotein) gene in colon carcinoma cell lines · Thomas O. Frommel · 1993 · 37 citations · Cited by this paper
  37. Impact of gut microbiota on kidney transplantation · Poramed Winichakoon · 2021 · 35 citations · Cited by this paper
  38. Gut microbiota composition alterations are associated with the onset of diabetes in kidney transplant recipients · Marie Lecronier · 2020 · 32 citations · Cited by this paper
  39. Tacrolimus Pharmacokinetics is Associated with Gut Microbiota Diversity in Kidney Transplant Patients: Results from a Pilot Cross‐Sectional Study · Alexandra Louise Degraeve · 2023 · 30 citations · Cited by this paper

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