Research map: Insights into natural polysaccharides in alleviating drug-induced liver injury: Protective mechanisms and recent advances

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  1. Drug induced liver injury: an update · Miren García‐Cortés · 2020 · 285 citations · Cited by this paper
  2. Panax notoginseng polysaccharides: a review focusing on the extraction, isolation, structural characterization, biological activities, and applications · 2025 · Related
  3. Structural characterization, antioxidant and hepatoprotective activities of polysaccharides from Sophorae tonkinensis Radix · Liangliang Cai · 2018 · 208 citations · Cited by this paper
  4. Comprehensive analysis of the association between perfluorooctanoic acid exposure and osteosarcoma progression · 2026 · Related
  5. Astaxanthin Activated the Nrf2/HO-1 Pathway to Enhance Autophagy and Inhibit Ferroptosis, Ameliorating Acetaminophen-Induced Liver Injury · Xiaopeng Cai · 2022 · 195 citations · Cited by this paper
  6. The tire antioxidant derivative 6PPD-quinone exacerbates IBD by targeting NR1H4-mediated lipid metabolism and mitochondrial dysfunction in human colon epithelial cells · 2026 · Related
  7. Chemoprotective effects of Ganoderma atrum polysaccharide in cyclophosphamide-induced mice · Qiang Yu · 2013 · 147 citations · Cited by this paper
  8. Alternariol, a mycotoxin, induces oxidative stress, inflammation, and apoptosis in human astrocytes: Protective effects of eicosapentaenoic acid · 2026 · Related
  9. Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro · Peng Cao · 2018 · 144 citations · Cited by this paper
  10. Integrative network toxicology identifies SLC5A2 as a key mediator of tetrasodium pyrophosphate-induced renal fibrosis · 2026 · Related
  11. Structural characterization and hepatoprotective activities of polysaccharides from the leaves of Toona sinensis (A. Juss) Roem · Juanjuan Cao · 2019 · 140 citations · Cited by this paper
  12. RIFM fragrance ingredient safety assessment, 3,5,5-trimethylcyclohexanol, CAS Registry Number 116-02-9 · 2026 · Related
  13. Gardenia jasminoides Ellis polysaccharide ameliorates cholestatic liver injury by alleviating gut microbiota dysbiosis and inhibiting the TLR4/NF-κB signaling pathway · Su Fang · 2022 · 131 citations · Cited by this paper
  14. BPAF-induced inflammatory response via estrogen signaling: insights from in vivo and in vitro evidence · 2026 · Related
  15. Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling · Kai Markus Schneider · 2021 · 126 citations · Cited by this paper
  16. Update to RIFM fragrance ingredient safety assessment, 2-propanol, 1,1′,1′,1'-(1,2-ethanediyldinitrilo)tetrakis-, CAS Registry Number 102-60-3 · 2026 · Related
  17. The liver in regulation of iron homeostasis · Gautam Rishi · 2017 · 122 citations · Cited by this paper
  18. Redox-dependent cytoprotection by zerumbone via Nrf2–Keap1 mediated restoration of antioxidant and apoptotic balance in Mancozeb-exposed cells · 2026 · Related
  19. Antioxidant and hepatoprotective activities of polysaccharides from Anoectochilus roxburghii · Zeng Biyu · 2016 · 118 citations · Cited by this paper
  20. Drug‐induced liver injury (DILI) ascribed to non‐steroidal anti‐inflammatory drugs (NSAIDs) in the USA—Update with genetic correlations · 2024 · Related
  21. Hepatoprotective effects exerted by Poria Cocos polysaccharides against acetaminophen-induced liver injury in mice · Ka Wu · 2018 · 108 citations · Cited by this paper
  22. Hepatoprotective activity of chitosan against isoniazid and rifampicin-induced toxicity in experimental rats · Sethumadhavan Santhosh · 2007 · 104 citations · Cited by this paper
  23. Low molecular weight polysaccharide of Tremella fuciformis exhibits stronger antioxidant and immunomodulatory activities than high molecular weight polysaccharide · Quancen Lee · 2024 · 98 citations · Cited by this paper
  24. Isolation and Characterization of Immunostimulatory Polysaccharide from an Herb Tea, Gynostemma pentaphyllum Makino · Xingbin Yang · 2008 · 92 citations · Cited by this paper
  25. Characterization, antioxidant activity and hepatoprotective effect of purple sweetpotato polysaccharides · Jian Ge Sun · 2018 · 91 citations · Cited by this paper
  26. Dietary litchi pulp polysaccharides could enhance immunomodulatory and antioxidant effects in mice · Fei Huang · 2016 · 88 citations · Cited by this paper
  27. Peroxiredoxin 3 Inhibits Acetaminophen-Induced Liver Pyroptosis Through the Regulation of Mitochondrial ROS · Yue Wang · 2021 · 82 citations · Cited by this paper
  28. Relationship between molecular weight, monosaccharide composition and immunobiologic activity of Astragalus polysaccharides · Yiping Jiang · 2016 · 81 citations · Cited by this paper
  29. Polysaccharide from natural Cordyceps sinensis ameliorated intestinal injury and enhanced antioxidant activity in immunosuppressed mice · Shuping Chen · 2018 · 80 citations · Cited by this paper
  30. Human Leukocyte Antigen B*14:01 and B*35:01 Are Associated With Trimethoprim‐Sulfamethoxazole Induced Liver Injury · Yi‐Ju Li · 2020 · 76 citations · Cited by this paper
  31. Structure and hepatoprotective activity of Usp10/NF-κB/Nrf2 pathway-related Morchella esculenta polysaccharide · Shanshan Teng · 2022 · 76 citations · Cited by this paper
  32. Fucoidan Alleviates Acetaminophen-Induced Hepatotoxicity via Oxidative Stress Inhibition and Nrf2 Translocation · Yuqin Wang · 2018 · 74 citations · Cited by this paper
  33. Infliximab-induced liver injury: Clinical phenotypes, autoimmunity and the role of corticosteroid treatment · Helgi Kristinn Björnsson · 2021 · 74 citations · Cited by this paper
  34. Hepatoprotective Effect of Polysaccharides Isolated from Dendrobium officinale against Acetaminophen‐Induced Liver Injury in Mice via Regulation of the Nrf2‐Keap1 Signaling Pathway · Guosheng Lin · 2018 · 73 citations · Cited by this paper
  35. USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice · Changzhou Cai · 2023 · 72 citations · Cited by this paper
  36. A new framework for advancing in drug‐induced liver injury research. The Prospective European DILI Registry · Einar Stefan Bjornsson · 2022 · 71 citations · Cited by this paper
  37. Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice · Nga Nguyen · 2020 · 69 citations · Cited by this paper
  38. Value of liver biopsy in the diagnosis of drug-induced liver injury · Jawad Ahmad · 2022 · 69 citations · Cited by this paper
  39. Antioxidant and hepatoprotective effects of purified Rhodiola rosea polysaccharides · Yao Qun Xu · 2018 · 67 citations · Cited by this paper

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