Research map: The Janus face of statins in viral infections: integrating findings from preclinical and clinical studies

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  1. Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation · Jin Ye · 2003 · 362 citations · Cited by this paper
  2. Emerging evidence of viral involvement in testicular and penile carcinogenesis · 2026 · Related
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  5. Influenza and COPD Mortality Protection as Pleiotropic, Dose-Dependent Effects of Statins · Floyd J. Frost · 2007 · 305 citations · Cited by this paper
  6. Exosome-based strategies for COVID-19: a comprehensive review of diagnostic and therapeutic applications · 2026 · Related
  7. Statins Inhibit HIV-1 Infection by Down-regulating Rho Activity · Gustavo del Real · 2004 · 297 citations · Cited by this paper
  8. Incidentally detected acute hepatitis B and concomitant acute acalculous cholecystitis: a rare case report · 2026 · Related
  9. Identification of FBL2 As a Geranylgeranylated Cellular Protein Required for Hepatitis C Virus RNA Replication · Chunfu Wang · 2005 · 295 citations · Cited by this paper
  10. Bulevirtide, the first targeted therapy for chronic hepatitis D: what we know up to now · 2025 · Related
  11. Statins and the COVID-19 main protease: in silico evidence on direct interaction · Željko Reiner · 2020 · 273 citations · Cited by this paper
  12. New antiviral peptides inhibit in vitro infection of SARS-CoV-2 · 2025 · Related
  13. Cholesterol biosynthesis modulation regulates dengue viral replication · Christopher Rothwell · 2009 · 270 citations · Cited by this paper
  14. Photodynamic therapy at low power laser enhances the oncolytic Newcastle disease virus in killing breast cancer cells · 2026 · Related
  15. Hydrophilic or Lipophilic Statins? · Elisenda Climent · 2021 · 243 citations · Cited by this paper
  16. Clinical markers dysregulation during HTLV-1 infection and associated diseases · 2026 · Related
  17. Meta-analysis of Effect of Statins in Patients with COVID-19 · Chia Siang Kow · 2020 · 195 citations · Cited by this paper
  18. Advancements in rabies immunization: transformations from early trials to cutting-edge technologies · 2026 · Related
  19. Statins and neuroprotection · W. Gibson Wood · 2010 · 162 citations · Cited by this paper
  20. When defense backfires: inflammatory determinants of RSV-induced disease severity · 2026 · Related
  21. Lipid Raft Disruption by Cholesterol Depletion Enhances Influenza A Virus Budding from MDCK Cells · Subrata Barman · 2007 · 159 citations · Cited by this paper
  22. Lovastatin for the Treatment of Adult Patients With Dengue: A Randomized, Double-Blind, Placebo-Controlled Trial · James Whitehorn · 2015 · 156 citations · Cited by this paper
  23. Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells · Sin-Ting Wang · 2017 · 152 citations · Cited by this paper
  24. Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication · Junjun Chu · 2021 · 149 citations · Cited by this paper
  25. Lipophilic Statins and Risk for Hepatocellular Carcinoma and Death in Patients With Chronic Viral Hepatitis: Results From a Nationwide Swedish Population · Tracey G. Simon · 2019 · 144 citations · Cited by this paper
  26. Replication and Expression Strategies of Viruses · Sephra Nalini Rampersad · 2018 · 141 citations · Cited by this paper
  27. Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication · Caroline G. Williams · 2021 · 126 citations · Cited by this paper
  28. Influenza Morbidity and Mortality in Elderly Patients Receiving Statins: A Cohort Study · Jeffrey C. Kwong · 2009 · 108 citations · Cited by this paper
  29. Cerivastatin, genetic variants, and the risk of rhabdomyolysis · Kristin D. Marciante · 2011 · 105 citations · Cited by this paper
  30. Lovastatin Delays Infection and Increases Survival Rates in AG129 Mice Infected with Dengue Virus Serotype 2 · Marlén Martínez‐Gutierrez · 2014 · 103 citations · Cited by this paper
  31. HIV-1 Gag specifically restricts PI(4,5)P2 and cholesterol mobility in living cells creating a nanodomain platform for virus assembly · Cyril Favard · 2019 · 93 citations · Cited by this paper
  32. Improved COVID-19 ICU admission and mortality outcomes following treatment with statins: a systematic review and meta-analysis · Amir Vahedian‐Azimi · 2021 · 93 citations · Cited by this paper
  33. Statin Use and the Risk of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B · Myung Ji Goh · 2019 · 89 citations · Cited by this paper
  34. Effect of statin therapy on SARS-CoV-2 infection-related mortality in hospitalized patients · L. Masana · 2020 · 86 citations · Cited by this paper
  35. Atorvastatin versus placebo in patients with covid-19 in intensive care: randomized controlled trial · INSPIRATION-S Investigators · 2022 · 84 citations · Cited by this paper
  36. Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection · Peiran Chen · 2023 · 83 citations · Cited by this paper
  37. Antiviral effects of statins · Armita Mahdavi Gorabi · 2020 · 76 citations · Cited by this paper
  38. Statins reduce mortality in patients with COVID-19: an updated meta-analysis of 147 824 patients · Carlos Diaz‐Arocutipa · 2021 · 75 citations · Cited by this paper
  39. Pharmacogenetics of statins treatment: Efficacy and safety · Ziwan Guan · 2019 · 74 citations · Cited by this paper

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