Research map: siRNA‐Based Nanodrug Delivery Systems in the Treatment of Autoimmune Diseases

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  1. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans · Andrew Z. Fire · 1998 · 15524 citations · Cited by this paper
  2. Dynamics of Circulating Follicular Helper and Regulatory T‐Cell Memory Induced by mRNA, Inactivated, and Live‐Attenuated Vaccines · 2026 · Related
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  5. The non-canonical NF-κB pathway in immunity and inflammation · Shao‐Cong Sun · 2017 · 1953 citations · Cited by this paper
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  7. Sensing of RNA Viruses: a Review of Innate Immune Receptors Involved in Recognizing RNA Virus Invasion · Søren B. Jensen · 2012 · 623 citations · Cited by this paper
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  9. Innate immune mechanisms of mRNA vaccines · Rein Verbeke · 2022 · 513 citations · Cited by this paper
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  11. Macrophage M1/M2 polarization and rheumatoid arthritis: A systematic review · Samuele Tardito · 2019 · 454 citations · Cited by this paper
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  13. siRNA: Mechanism of action, challenges, and therapeutic approaches · Walhan Alshaer · 2021 · 439 citations · Cited by this paper
  14. The Role of BMAL1 in Regulating Circadian Rhythms During Airway Remodeling in Asthma · 2026 · Related
  15. Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax) · J D Leverson · 2015 · 438 citations · Cited by this paper
  16. Cytokine Changes With Effective Drug Therapy for Juvenile Myasthenia Gravis · 2026 · Related
  17. Cell and molecular biology of Notch · Ulla-Maj Fiúza · 2007 · 372 citations · Cited by this paper
  18. Anti‐MAG Polyneuropathy: Characterization of the Monoclonal Gammopathy and Clonal B‐Cell Population · 2026 · Related
  19. Monocytes in rheumatoid arthritis: Circulating precursors of macrophages and osteoclasts and, their heterogeneity and plasticity role in RA pathogenesis · Amit Kumar Rana · 2018 · 306 citations · Cited by this paper
  20. Therapeutic Potential of Nanocarriers in the Management of Rheumatoid Arthritis · 2024 · Related
  21. B Cells in Rheumatoid Arthritis：Pathogenic Mechanisms and Treatment Prospects · Fengping Wu · 2021 · 266 citations · Cited by this paper
  22. A protocol for designing siRNAs with high functionality and specificity · Amanda Birmingham · 2007 · 224 citations · Cited by this paper
  23. Targeting NF-kB signaling with polymeric hybrid micelles that co-deliver siRNA and dexamethasone for arthritis therapy · Qin Wang · 2017 · 221 citations · Cited by this paper
  24. siRNA Specificity: RNAi Mechanisms and Strategies to Reduce Off-Target Effects · Julia Neumeier · 2021 · 201 citations · Cited by this paper
  25. Precise and efficient siRNA design: a key point in competent gene silencing · Elham Fakhr · 2016 · 194 citations · Cited by this paper
  26. IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting · Lori Broderick · 2022 · 174 citations · Cited by this paper
  27. Fab'-bearing siRNA TNFα-loaded nanoparticles targeted to colonic macrophages offer an effective therapy for experimental colitis · Hamed Laroui · 2014 · 160 citations · Cited by this paper
  28. Notch Targets and Their Regulation · Sarah J. Bray · 2010 · 159 citations · Cited by this paper
  29. Macrophages with regulatory functions, a possible new therapeutic perspective in autoimmune diseases · Paola Di Benedetto · 2019 · 148 citations · Cited by this paper
  30. Alzheimer’s disease and Notch signaling · Ha‐Na Woo · 2009 · 141 citations · Cited by this paper
  31. Notch1 targeting siRNA delivery nanoparticles for rheumatoid arthritis therapy · Min Ju Kim · 2015 · 120 citations · Cited by this paper
  32. Combination of NF-kB targeted siRNA and methotrexate in a hybrid nanocarrier towards the effective treatment in rheumatoid arthritis · Weifeng Duan · 2018 · 117 citations · Cited by this paper
  33. Evolving concepts of the pathogenesis of rheumatoid arthritis with focus on the early and late stages · Frédéric Coutant · 2019 · 112 citations · Cited by this paper
  34. Mcl-1 Is Essential for the Survival of Synovial Fibroblasts in Rheumatoid Arthritis · Hongtao Liu · 2005 · 92 citations · Cited by this paper
  35. Notch and the regulation of osteoclast differentiation and function · Jungeun Yu · 2020 · 82 citations · Cited by this paper
  36. Machine learning application in autoimmune diseases: State of art and future prospectives · Maria Giovanna Danieli · 2023 · 77 citations · Cited by this paper
  37. In vivo therapeutic efficacy of TNFα silencing by folate-PEG-chitosan-DEAE/siRNA nanoparticles in arthritic mice · Qin Shi · 2018 · 76 citations · Cited by this paper
  38. Regulation of Mcl‐1 expression in rheumatoid arthritis synovial macrophages · Hongtao Liu · 2006 · 71 citations · Cited by this paper
  39. Recent Advances and Prospects in RNA Drug Development · Hidenori Tani · 2024 · 70 citations · Cited by this paper

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