Research map: Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance

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Papers in this map

  1. Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein · Mark Stuart Anderson · 2002 · 2502 citations · Cited by this paper
  2. STAT2 Mediated Epigenetic and Epitranscriptomic Regulation of CD4 + T Helper Cell Differentiation in Non‐Small Cell Lung Cancer ( NSCLC ) · 2026 · Related
  3. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules · Kirsten Falk · 1991 · 2437 citations · Cited by this paper
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  5. SYFPEITHI: database for MHC ligands and peptide motifs · Hans‐Georg Rammensee · 1999 · 2346 citations · Cited by this paper
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  7. Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see) · Ludger Klein · 2014 · 1425 citations · Cited by this paper
  8. Precision Glyco‐Modulated GcMAF2.0 Targets CLEC10A to Bidirectionally Re‐Wire Macrophage States: Cross‐Species Evidence, Mechanistic Omics and Translational Horizons · 2026 · Related
  9. Characterization of Peptides Bound to the Class I MHC Molecule HLA-A2.1 by Mass Spectrometry · Donald F. Hunt · 1992 · 1214 citations · Cited by this paper
  10. HIF1α Activates Glycolysis to Suppress Mycobacterium tuberculosis Growth in Mouse Bone Marrow‐Derived Macrophages · 2026 · Related
  11. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self · Jens Derbinski · 2001 · 1085 citations · Cited by this paper
  12. Methionine Regulates Antitumour Function of CD8 + T Cells Through Polyamine Synthesis · 2026 · Related
  13. Comparative Analysis of Proteome and Transcriptome Variation in Mouse · Anatole Ghazalpour · 2011 · 662 citations · Cited by this paper
  14. MyD88 ‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions · 2026 · Related
  15. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels · Jens Derbinski · 2005 · 555 citations · Cited by this paper
  16. Dual Functions of Treg in the Mucosal Barrier and Lung Cancer Microenvironment and Prospects for Targeted Therapy · 2026 · Related
  17. Central Tolerance to Tissue-specific Antigens Mediated by Direct and Indirect Antigen Presentation · Alena M. Gallegos · 2004 · 490 citations · Cited by this paper
  18. AIRE's Complex Role Beyond Promiscuous Gene Expression · 2025 · Related
  19. Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance · Hiroyuki Takaba · 2015 · 399 citations · Cited by this paper
  20. Single-cell RNA-seq of in vitro–cultured medullary thymic epithelial cells reveals a preserved differentiation trajectory under Aire deficiency · 2026 · Related
  21. Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters · Jörn Gotter · 2004 · 359 citations · Cited by this paper
  22. The Mechanisms of T Cell Selection in the Thymus · Hiroyuki Takaba · 2017 · 298 citations · Cited by this paper
  23. The utility of protein and mRNA correlation · Samuel Payne · 2014 · 244 citations · Cited by this paper
  24. Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells · Daniel A. Michelson · 2022 · 221 citations · Cited by this paper
  25. Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells · Matthieu Giraud · 2011 · 180 citations · Cited by this paper
  26. The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation · Étienne Caron · 2011 · 135 citations · Cited by this paper
  27. Twenty Years of AIRE · Roberto Perniola · 2018 · 116 citations · Cited by this paper
  28. Biologically indeterminate yet ordered promiscuous gene expression in single medullary thymic epithelial cells · Fatima Dhalla · 2019 · 105 citations · Cited by this paper
  29. Combined transient ablation and single-cell RNA-sequencing reveals the development of medullary thymic epithelial cells · Kristen L. Wells · 2020 · 102 citations · Cited by this paper
  30. Exploring the MHC-peptide matrix of central tolerance in the human thymus · Eleni Adamopoulou · 2013 · 91 citations · Cited by this paper
  31. Self-peptides bound to the type I diabetes associated class II MHC molecules HLA-DQ1 and HLA-DQ8 · Roman M. Chicz · 1994 · 88 citations · Cited by this paper
  32. Update on Aire and thymic negative selection · Geraldo Aleixo Silva Passos · 2017 · 85 citations · Cited by this paper
  33. MHC Class I Immunopeptidome: Past, Present, and Future · Jonathan Wilson Yewdell · 2022 · 81 citations · Cited by this paper
  34. Age-Related Changes in Thymic Central Tolerance · Jayashree Srinivasan · 2021 · 77 citations · Cited by this paper
  35. Medullary thymic epithelial cell depletion leads to autoimmune hepatitis · Anthony John Bonito · 2013 · 73 citations · Cited by this paper
  36. The impact of DM on MHC class II–restricted antigen presentation can be altered by manipulation of MHC–peptide kinetic stability · Christopher A. Lazarski · 2006 · 67 citations · Cited by this paper
  37. Immune tolerance and the prevention of autoimmune diseases essentially depend on thymic tissue homeostasis · Fatemeh Shirafkan · 2024 · 61 citations · Cited by this paper
  38. The thymus road to a T cell: migration, selection, and atrophy · Mario Pérez · 2024 · 51 citations · Cited by this paper
  39. Promiscuous Gene Expression in the Thymus: A Matter of Epigenetics, miRNA, and More? · Olga Ucar · 2015 · 45 citations · Cited by this paper

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