Research map: Autophagy in MASLD : A Metabolic and Precision Medicine Perspective

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Papers in this map

  1. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 · Joungmok Kim · 2011 · 7303 citations · Cited by this paper
  2. Ketogenesis as a Metabolic Checkpoint in MASLD: Implications for Disease Progression and Therapy · Ambrin Farizah Babu · 2026 · Cites this paper
  3. Enhanced Liver Fibrosis Test, FIB ‐4 and FibroScan : Real‐World Prognostic Accuracy for MASLD in a Biopsy‐Controlled Cohort · 2026 · Related
  4. Autophagy regulates lipid metabolism · Rajat Singh · 2009 · 4038 citations · Cited by this paper
  5. Threshold‐Defined Liver Stiffness Trajectories and Liver‐Related Event Risk in Chronic Liver Disease: A Cohort Study · 2026 · Related
  6. Autophagy: cellular and molecular mechanisms · D.R. Glick · 2010 · 3855 citations · Cited by this paper
  7. Lactulose for Preventing Overt Hepatic Encephalopathy: Between Evidence and Unresolved Questions · 2026 · Related
  8. Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis · Arun Jayant Sanyal · 2010 · 3352 citations · Cited by this paper
  9. Laparoscopic or Open Liver Resection Versus Multibipolar Radiofrequency Ablation of HCC Within Milan Criteria on Cirrhosis · 2026 · Related
  10. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 · Masaaki Komatsu · 2010 · 2456 citations · Cited by this paper
  11. Neurofilament Light Chain in Cerebrospinal Fluid and Blood Identifies Patients With Minimal and Overt Hepatic Encephalopathy · 2026 · Related
  12. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene · Xueping Qu · 2003 · 2255 citations · Cited by this paper
  13. Microtubule‐Targeting Drugs Induce Mesenchymal–Epithelial Transition in Hepatic Stellate Cells · 2026 · Related
  14. Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice · Masaaki Komatsu · 2007 · 2145 citations · Cited by this paper
  15. Burden and Regional Disparities of MASH ‐Related Liver Cancer in the Asia‐Pacific Region From 1990 to 2023 · 2026 · Related
  16. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor · Zhenyu Yue · 2003 · 2121 citations · Cited by this paper
  17. High Rates of Advanced Chronic Liver Disease in Patients With Chronic Hepatitis D Virus Infection in Uzbekistan · 2026 · Related
  18. Autophagy-deficient mice develop multiple liver tumors · Akito Takamura · 2011 · 1348 citations · Cited by this paper
  19. Semaglutide Ameliorates Hepatocyte Steatosis in a Cell Co-Culture System by Downregulating the IRE1α-XBP1-C/EBPα Signaling Pathway in Macrophages · 2024 · Related
  20. NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice · Auvro R. Mridha · 2017 · 1117 citations · Cited by this paper
  21. Deficient chaperone‐mediated autophagy in macrophage aggravates inflammation of nonalcoholic steatohepatitis by targeting Nup85 · 2023 · Related
  22. Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex · Yun Zhong · 2009 · 1007 citations · Cited by this paper
  23. Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis · Arun J. Sanyal · 2025 · 985 citations · Cited by this paper
  24. Autophagy in inflammation, infection, and immunometabolism · Vojo P. Deretic · 2021 · 871 citations · Cited by this paper
  25. Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD · Águeda González‐Rodríguez · 2014 · 643 citations · Cited by this paper
  26. PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria · Kei Okatsu · 2012 · 612 citations · Cited by this paper
  27. Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization · Kun Liu · 2015 · 549 citations · Cited by this paper
  28. Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci · Stefan Stender · 2017 · 406 citations · Cited by this paper
  29. Statin use and non-alcoholic steatohepatitis in at risk individuals · Paola Dongiovanni · 2015 · 393 citations · Cited by this paper
  30. Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice · Satoshi Tanaka · 2016 · 382 citations · Cited by this paper
  31. ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism · Aishwarya Sathyanarayan · 2017 · 375 citations · Cited by this paper
  32. TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content · Hovsep Mahdessian · 2014 · 373 citations · Cited by this paper
  33. Emerging roles of SIRT1 in fatty liver diseases · Ren‐Bo Ding · 2017 · 366 citations · Cited by this paper
  34. MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo · X-X He · 2011 · 344 citations · Cited by this paper
  35. Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway · Youngmi Song · 2014 · 333 citations · Cited by this paper
  36. The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation · Soumik BasuRay · 2017 · 301 citations · Cited by this paper
  37. Metabolic Dysfunction–Associated Steatotic Liver Disease · Giovanni Targher · 2025 · 297 citations · Cited by this paper
  38. miR-375 Inhibits Autophagy and Reduces Viability of Hepatocellular Carcinoma Cells Under Hypoxic Conditions · Ying Chang · 2012 · 291 citations · Cited by this paper
  39. Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury · Maria Ruart · 2018 · 284 citations · Cited by this paper

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