Research map: IL ‐6/ IL ‐ 6R ‐Mediated Mechanisms in Lung Cancer: From Pathogenesis to Potential Therapeutic Targets

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  1. Principles of interleukin (IL)-6-type cytokine signalling and its regulation · Peter Claus Heinrich · 2003 · 3290 citations · Cited by this paper
  2. STAT2 Mediated Epigenetic and Epitranscriptomic Regulation of CD4 + T Helper Cell Differentiation in Non‐Small Cell Lung Cancer ( NSCLC ) · 2026 · Related
  3. The pro- and anti-inflammatory properties of the cytokine interleukin-6 · Jürgen Scheller · 2011 · 3248 citations · Cited by this paper
  4. Strategies of AI ‐Driven CAR ‐T Cell Therapy Towards Solid Tumours · 2026 · Related
  5. NF-κB, inflammation, immunity and cancer: coming of age · Koji Taniguchi · 2018 · 2768 citations · Cited by this paper
  6. Epigenetic Gene Networks Governing Immune State Transitions Across the Lifespan · 2026 · Related
  7. IL-6 as a keystone cytokine in health and disease · Christopher A. Hunter · 2015 · 2556 citations · Cited by this paper
  8. Precision Glyco‐Modulated GcMAF2.0 Targets CLEC10A to Bidirectionally Re‐Wire Macrophage States: Cross‐Species Evidence, Mechanistic Omics and Translational Horizons · 2026 · Related
  9. Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery · Bryan T. Hennessy · 2005 · 2191 citations · Cited by this paper
  10. HIF1α Activates Glycolysis to Suppress Mycobacterium tuberculosis Growth in Mouse Bone Marrow‐Derived Macrophages · 2026 · Related
  11. Cancer Progress and Priorities: Lung Cancer · Matthew B. Schabath · 2019 · 1189 citations · Cited by this paper
  12. Methionine Regulates Antitumour Function of CD8 + T Cells Through Polyamine Synthesis · 2026 · Related
  13. Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer · Simon A. Jones · 2018 · 1133 citations · Cited by this paper
  14. MyD88 ‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions · 2026 · Related
  15. Role of interleukin-6 in cancer progression and therapeutic resistance · Neeraj Kumari · 2016 · 1110 citations · Cited by this paper
  16. Dual Functions of Treg in the Mucosal Barrier and Lung Cancer Microenvironment and Prospects for Targeted Therapy · 2026 · Related
  17. IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6 · Stefan Rose‐John · 2012 · 1041 citations · Cited by this paper
  18. Lung Cancer in Older Adults: Screening, Diagnosis, and Treatment · 2025 · Related
  19. Epidemiology of lung cancer · Krishna Chaitanya Thandra · 2021 · 893 citations · Cited by this paper
  20. IL‑6: A key player in the EGFR‑TKI‑resistant tumor microenvironment and its therapeutic implications (Review) · 2026 · Related
  21. Interleukin-6 signaling pathway in targeted therapy for cancer · Yuqi Guo · 2012 · 698 citations · Cited by this paper
  22. Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). · T Hirano · 1985 · 684 citations · Cited by this paper
  23. Soluble gp130 is the natural inhibitor of soluble interleukin‐6 receptor transsignaling responses · Thomas Jostock · 2001 · 655 citations · Cited by this paper
  24. Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. · Takeshi Nakajima · 1993 · 589 citations · Cited by this paper
  25. IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer · Thomas A. Mace · 2016 · 563 citations · Cited by this paper
  26. Inflammation and Cancer: IL-6 and STAT3 Complete the Link · Jacqueline Bromberg · 2009 · 548 citations · Cited by this paper
  27. Changes in serum interleukin-8 (IL-8) levels reflect and predict response to anti-PD-1 treatment in melanoma and non-small-cell lung cancer patients · Miguel F. Sanmamed · 2017 · 469 citations · Cited by this paper
  28. The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition · Christoph Garbers · 2015 · 444 citations · Cited by this paper
  29. Plasticity and cross-talk of Interleukin 6-type cytokines · Christoph Garbers · 2012 · 405 citations · Cited by this paper
  30. Cellular Cholesterol Depletion Triggers Shedding of the Human Interleukin-6 Receptor by ADAM10 and ADAM17 (TACE) · Vance Bruce Matthews · 2003 · 391 citations · Cited by this paper
  31. TGF-β IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer · Zhan Yao · 2010 · 390 citations · Cited by this paper
  32. Cancer Development, Progression, and Therapy: An Epigenetic Overview · Sibaji Sarkar · 2013 · 389 citations · Cited by this paper
  33. Cytokine and cytokine receptor gene polymorphisms and their functionality · Andrew J P Smith · 2008 · 384 citations · Cited by this paper
  34. The role of intratumoral and systemic IL-6 in breast cancer · Christine Dethlefsen · 2013 · 381 citations · Cited by this paper
  35. Autocrine IL-6 Signaling: A Key Event in Tumorigenesis? · Sergei I. Grivennikov · 2008 · 374 citations · Cited by this paper
  36. Global burden of lung cancer in 2022 and projections to 2050: Incidence and mortality estimates from GLOBOCAN · Jialin Zhou · 2024 · 372 citations · Cited by this paper
  37. The IL-6/sIL-6R complex as a novel target for therapeutic approaches · Stefan Rose‐John · 2007 · 363 citations · Cited by this paper
  38. Tocilizumab inhibits signal transduction mediated by both mIL-6R and sIL-6R, but not by the receptors of other members of IL-6 cytokine family · Masahiko Mihara · 2005 · 332 citations · Cited by this paper
  39. Combined Blockade of IL6 and PD-1/PD-L1 Signaling Abrogates Mutual Regulation of Their Immunosuppressive Effects in the Tumor Microenvironment · Hirotake Tsukamoto · 2018 · 309 citations · Cited by this paper

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