Research map: Sex-dependent mechanisms in rheumatic diseases

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Papers in this map

  1. Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity · Janet Markle · 2013 · 2089 citations · Cited by this paper
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  5. Translocation of a gut pathobiont drives autoimmunity in mice and humans · Silvio Manfredo Vieira · 2018 · 856 citations · Cited by this paper
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  7. Is the incidence of rheumatoid arthritis rising?: Results from Olmsted County, Minnesota, 1955–2007 · Elena Myasoedova · 2010 · 815 citations · Cited by this paper
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  10. 20 years of progress in the classification of immune-mediated diseases · 2026 · Related
  11. TLR7 escapes X chromosome inactivation in immune cells · Mélanie Souyris · 2018 · 664 citations · Cited by this paper
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  13. MicroRNA-21 and MicroRNA-148a Contribute to DNA Hypomethylation in Lupus CD4+ T Cells by Directly and Indirectly Targeting DNA Methyltransferase 1 · Wen Qi Pan · 2010 · 564 citations · Cited by this paper
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  15. Cutting Edge: Estrogen Drives Expansion of the CD4+CD25+ Regulatory T Cell Compartment · Magdalena J. Polanczyk · 2004 · 526 citations · Cited by this paper
  16. Rethinking early-stage knee osteoarthritis beyond radiography · 2026 · Related
  17. Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: Support for the notion of a gene‐dose effect from the X chromosome · Robert Hal Scofield · 2008 · 429 citations · Cited by this paper
  18. PD-1 agonism puts the brakes on pathogenic T cell responses in RA · 2026 · Related
  19. Estrogen regulates the IFN-gamma promoter · Howard S. Fox · 1991 · 425 citations · Cited by this paper
  20. Sex differences in systemic sclerosis: from pathogenesis to clinical manifestations and treatment · 2025 · Related
  21. Half- vs Full-Dose Trivalent Inactivated Influenza Vaccine (2004-2005) · Renata J.M. Engler · 2008 · 332 citations · Cited by this paper
  22. The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor α signaling · Cyril Seillet · 2011 · 330 citations · Cited by this paper
  23. Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus · Teri M. Greiling · 2018 · 323 citations · Cited by this paper
  24. Estrogen directly activates AID transcription and function · Siim Pauklin · 2009 · 274 citations · Cited by this paper
  25. The gut microbiota is a major regulator of androgen metabolism in intestinal contents · Hannah Colldén · 2019 · 260 citations · Cited by this paper
  26. B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells · Bingfei Yu · 2021 · 228 citations · Cited by this paper
  27. Overexpression of X-Linked genes in T cells from women with lupus · Anura Hewagama · 2013 · 224 citations · Cited by this paper
  28. Sex steroid effects at target tissues: mechanisms of action · Margaret E. Wierman · 2007 · 217 citations · Cited by this paper
  29. Estrogen-mediated downregulation of AIRE influences sexual dimorphism in autoimmune diseases · Nadine Dragin · 2016 · 211 citations · Cited by this paper
  30. Estrogen enhancement of anti–double‐stranded DNA antibody and immunoglobulin G production in peripheral blood mononuclear cells from patients with systemic lupus erythematosus · Naoko Kanda · 1999 · 183 citations · Cited by this paper
  31. X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome · Ke Liu · 2015 · 177 citations · Cited by this paper
  32. Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity · Antonios Psarras · 2020 · 177 citations · Cited by this paper
  33. Sexual disparities in the incidence and course of SLE and RA · Sara K. Tedeschi · 2013 · 171 citations · Cited by this paper
  34. The conceptual foundations of innate immunity: Taking stock 30 years later · Thomas Pradeu · 2024 · 171 citations · Cited by this paper
  35. Heterogeneous Escape from X Chromosome Inactivation Results in Sex Differences in Type I IFN Responses at the Single Human pDC Level · Sven Hendrik Hagen · 2020 · 163 citations · Cited by this paper
  36. Estrogen Receptor α Is Necessary in Thymic Development and Estradiol-Induced Thymic Alterations · Jennifer Erin Staples · 1999 · 161 citations · Cited by this paper
  37. Gender differences in systemic sclerosis: relationship to clinical features, serologic status and outcomes · Christine Peoples · 2016 · 157 citations · Cited by this paper
  38. Sex differences in Sjögren’s syndrome: a comprehensive review of immune mechanisms · Jessica E. Brandt · 2015 · 138 citations · Cited by this paper
  39. Obesity and breast cancer – Role of estrogens and the molecular underpinnings of aromatase regulation in breast adipose tissue · Céline Gérard · 2017 · 138 citations · Cited by this paper

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