Research map: Timing as biology: a hypothesis on the role of epigenetic plasticity in type 2 diabetes prevention

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Papers in this map

  1. Oxidative Stress and Diabetic Complications · Ferdinando Giacco · 2010 · 5511 citations · Cited by this paper
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  15. Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study · Ádám Gyula Tabák · 2009 · 904 citations · Cited by this paper
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  19. The Legacy Effect in Type 2 Diabetes: Impact of Early Glycemic Control on Future Complications (The Diabetes & Aging Study) · Neda Laiteerapong · 2018 · 579 citations · Cited by this paper
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  21. Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion · Tasnim Dayeh · 2014 · 533 citations · Cited by this paper
  22. Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion · Charlotte Ling · 2008 · 501 citations · Cited by this paper
  23. The “Metabolic Memory”: Is More Than Just Tight Glucose Control Necessary to Prevent Diabetic Complications? · Antonio Ceriello · 2008 · 415 citations · Cited by this paper
  24. Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes · Robert J. Wagner · 2021 · 407 citations · Cited by this paper
  25. Pancreatic β-cell dysfunction in type 2 diabetes: Implications of inflammation and oxidative stress · Phiwayinkosi Vusi Dludla · 2023 · 352 citations · Cited by this paper
  26. The Role of Oxidative Stress in Pancreatic β Cell Dysfunction in Diabetes · Natsuki Eguchi · 2021 · 349 citations · Cited by this paper
  27. Epigenetics and Metabolism · Samuel T. Keating · 2015 · 321 citations · Cited by this paper
  28. The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus · Joshua A. David · 2017 · 317 citations · Cited by this paper
  29. The Redox Basis of Epigenetic Modifications: From Mechanisms to Functional Consequences · Anthony Roger Cyr · 2010 · 296 citations · Cited by this paper
  30. Epigenetic regulation of Keap1-Nrf2 signaling · Yue Guo · 2015 · 263 citations · Cited by this paper
  31. Epigenetic phenomena linked to diabetic complications · Luciano Pirola · 2010 · 240 citations · Cited by this paper
  32. Mitochondrial dysfunction in pancreatic β cells · Sachin Supale · 2012 · 234 citations · Cited by this paper
  33. Metabolic memory phenomenon in diabetes mellitus: Achieving and perspectives · Alexander Е. Berezin · 2016 · 160 citations · Cited by this paper
  34. Antioxidants and Reactive Oxygen Species: Shaping Human Health and Disease Outcomes · Charles F. Manful · 2025 · 125 citations · Cited by this paper
  35. Effects of insulin resistance and insulin secretion on the efficacy of interventions to retard development of type 2 diabetes mellitus: the DA Qing IGT and Diabetes Study · Guangwei Li · 2002 · 110 citations · Cited by this paper
  36. Chop / Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice · Jing Yong · 2021 · 77 citations · Cited by this paper
  37. Age-Related Epigenetic Drift and Phenotypic Plasticity Loss: Implications in Prevention of Age-Related Human Diseases · Yuanyuan Li · 2016 · 76 citations · Cited by this paper
  38. Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetes · Tina Rönn · 2023 · 75 citations · Cited by this paper
  39. Regulation of Keap1–Nrf2 signaling: The role of epigenetics · David Cheng · 2016 · 74 citations · Cited by this paper

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