Research map: AMPK/USP10 loop activation of ACE2: implications for pulmonary hypertension

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  1. Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes · Steven P. Marso · 2016 · 7637 citations · Cited by this paper
  2. Disrupted erythrocyte S1P-eNOS axis promotes hypoxia, hypertension and fibrosis in obstructive sleep apnoea-hypopnoea syndrome · 2026 · Related
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  5. The p53-mdm-2 autoregulatory feedback loop. · Jun Wu · 1993 · 1807 citations · Cited by this paper
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  7. AMP-Activated Protein Kinase Induces a p53-Dependent Metabolic Checkpoint · Russell G. Jones · 2005 · 1623 citations · Cited by this paper
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  11. The ACE2/Angiotensin-(1–7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1–7) · Robson A.S. Santos · 2017 · 1177 citations · Cited by this paper
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  13. Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study · Arne Vernon Astrup · 2009 · 1168 citations · Cited by this paper
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  15. 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial · Carel Wynand le Roux · 2017 · 870 citations · Cited by this paper
  16. Mineralocorticoid receptor overactivation in heart failure with preserved ejection fraction · 2026 · Related
  17. Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13 · Junli Liu · 2011 · 835 citations · Cited by this paper
  18. Spotlight on EHRA 2026: illuminating arrhythmia management · 2026 · Related
  19. USP10 Regulates p53 Localization and Stability by Deubiquitinating p53 · Jian Hua Yuan · 2010 · 663 citations · Cited by this paper
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  21. Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53 · Hiroshi G. Katayama · 2003 · 593 citations · Cited by this paper
  22. ACE2 , angiotensin‐(1‐7) and M as receptor axis in inflammation and fibrosis · Ana Cristina Simões e Silva · 2013 · 550 citations · Cited by this paper
  23. Capillary cell-type specialization in the alveolus · Astrid Gillich · 2020 · 514 citations · Cited by this paper
  24. Regulating tumor suppressor genes: post-translational modifications · Ling Chen · 2020 · 468 citations · Cited by this paper
  25. Dysregulated Renin–Angiotensin–Aldosterone System Contributes to Pulmonary Arterial Hypertension · Frances S. de Man · 2012 · 350 citations · Cited by this paper
  26. Endothelial cells in the pathogenesis of pulmonary arterial hypertension · Colin E. Evans · 2021 · 331 citations · Cited by this paper
  27. Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase · Shani Ben‐Shlomo · 2010 · 328 citations · Cited by this paper
  28. Mapping the effectiveness and risks of GLP-1 receptor agonists · Yan Xie · 2025 · 289 citations · Cited by this paper
  29. The Angiotensin-Converting Enzyme 2/Angiogenesis-(1–7)/Mas Axis Confers Cardiopulmonary Protection against Lung Fibrosis and Pulmonary Hypertension · Vinayak Shenoy · 2010 · 282 citations · Cited by this paper
  30. The Role of ACE2 in Cardiovascular Physiology · Gavin Y. Oudit · 2003 · 261 citations · Cited by this paper
  31. ACE inhibition, ACE2 and angiotensin-(17) axis in kidney and cardiac inflammation and fibrosis · Ana Cristina Simões e Silva · 2016 · 257 citations · Cited by this paper
  32. A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension · Anna Ryan Hemnes · 2018 · 228 citations · Cited by this paper
  33. Angiotensin converting enzyme expression is increased in small pulmonary arteries of rats with hypoxia-induced pulmonary hypertension. · Nicholas W. Morrell · 1995 · 211 citations · Cited by this paper
  34. AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension · Jiao Zhang · 2018 · 189 citations · Cited by this paper
  35. RETRACTED ARTICLE: A glucagon-like peptide-1 (GLP-1) analogue, liraglutide, upregulates nitric oxide production and exerts anti-inflammatory action in endothelial cells · Yuichi Hattori · 2010 · 183 citations · Cited by this paper
  36. The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis · Xingyun Wang · 2019 · 170 citations · Cited by this paper
  37. Deubiquitination and Activation of AMPK by USP10 · Min Deng · 2016 · 160 citations · Cited by this paper
  38. MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension · Hui Shen · 2020 · 136 citations · Cited by this paper
  39. Deubiquitinase USP10 regulates Notch signaling in the endothelium · Radiance Lim · 2019 · 133 citations · Cited by this paper

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