Research map: Innate immune responses underlying local and systemic adverse reactions to mRNA-lipid nanoparticle vaccines

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Papers in this map

  1. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine · Fernando P. Polack · 2020 · 15748 citations · Cited by this paper
  2. Transduction of Batf family members provides distinct functions to mouse CD8+ T cells · 2026 · Related
  3. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine · Lindsey R. Baden · 2020 · 10909 citations · Cited by this paper
  4. In This Issue · 2026 · Related
  5. From inflammation to sickness and depression: when the immune system subjugates the brain · Robert Dantzer · 2007 · 7443 citations · Cited by this paper
  6. Distinct fibrosis-associated macrophage subsets coordinate iron metabolism in pulmonary fibrosis · 2026 · Related
  7. The NLRP3 inflammasome: molecular activation and regulation to therapeutics · Karen V. Swanson · 2019 · 4883 citations · Cited by this paper
  8. Lipid metabolic regulation of pathogenic type 2 immunity in the airway · 2026 · Related
  9. mRNA vaccines — a new era in vaccinology · Norbert Pardi · 2018 · 4712 citations · Cited by this paper
  10. TLR7 responses to nucleosides drive sialadenitis in Slc29a3-deficient mice · 2025 · Related
  11. Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection · David S. Khoury · 2021 · 4254 citations · Cited by this paper
  12. In This Issue · 2026 · Related
  13. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation · Paola Scaffidi · 2002 · 4245 citations · Cited by this paper
  14. Mitochondrial transfer-driven immune evasion in the tumor microenvironment · 2026 · Related
  15. Lipid nanoparticles for mRNA delivery · Xucheng Hou · 2021 · 4010 citations · Cited by this paper
  16. Interaction between neurons and microglia in healthy and disease states · 2025 · Related
  17. Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8 · Florian Heil · 2004 · 3984 citations · Cited by this paper
  18. Functional diversity and tissue-specific regulation of Group 2 innate lymphoid cells in barrier immunity · 2025 · Related
  19. An mRNA Vaccine against SARS-CoV-2 — Preliminary Report · Lisa A. Jackson · 2020 · 3520 citations · Cited by this paper
  20. A poorly reactogenic lipid nanoparticle-mRNA vaccine unveils an innate immune pathway for adverse reactions · 2026 · Related
  21. Immunological and Inflammatory Functions of the Interleukin-1 Family · Charles Anthony Dinarello · 2009 · 3504 citations · Cited by this paper
  22. Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA · Sandra S. Diebold · 2004 · 3457 citations · Cited by this paper
  23. Sterile inflammation: sensing and reacting to damage · Grace Chen · 2010 · 3057 citations · Cited by this paper
  24. Mechanism and Regulation of NLRP3 Inflammasome Activation · Yuan He · 2016 · 2801 citations · Cited by this paper
  25. DAMPs, PAMPs and alarmins: all we need to know about danger · Marco Emilio Bianchi · 2006 · 2794 citations · Cited by this paper
  26. Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates · Edward E. Walsh · 2020 · 2748 citations · Cited by this paper
  27. Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA · Katalin Karikó · 2005 · 2743 citations · Cited by this paper
  28. mRNA-based therapeutics — developing a new class of drugs · Uğur Şahin · 2014 · 2507 citations · Cited by this paper
  29. 5'-Triphosphate RNA Is the Ligand for RIG-I · Veit Hornung · 2006 · 2495 citations · Cited by this paper
  30. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases · Charles Anthony Dinarello · 2011 · 2277 citations · Cited by this paper
  31. Regulation of Adaptive Immunity by the Innate Immune System · Akiko Iwasaki · 2010 · 2165 citations · Cited by this paper
  32. The Interleukin-1 Family: Back to the Future · Cecília Garlanda · 2013 · 1975 citations · Cited by this paper
  33. Vaccine Adjuvants: Putting Innate Immunity to Work · Robert L. Coffman · 2010 · 1961 citations · Cited by this paper
  34. Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability · Katalin Karikó · 2008 · 1958 citations · Cited by this paper
  35. Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape · Jérôme Gilleron · 2013 · 1667 citations · Cited by this paper
  36. mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability · Linde Schoenmaker · 2021 · 1573 citations · Cited by this paper
  37. Key roles of adjuvants in modern vaccines · Steven G. Reed · 2013 · 1448 citations · Cited by this paper
  38. HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection · Ulf Andersson · 2011 · 1443 citations · Cited by this paper
  39. Emerging concepts in the science of vaccine adjuvants · Bali Pulendran · 2021 · 1428 citations · Cited by this paper

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