Research map: MyD88 ‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions

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Papers in this map

  1. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors · Taro Kawai · 2010 · 9360 citations · Cited by this paper
  2. STAT2 Mediated Epigenetic and Epitranscriptomic Regulation of CD4 + T Helper Cell Differentiation in Non‐Small Cell Lung Cancer ( NSCLC ) · 2026 · Related
  3. NF-κB signaling in inflammation · Ting Liu · 2017 · 8533 citations · Cited by this paper
  4. Strategies of AI ‐Driven CAR ‐T Cell Therapy Towards Solid Tumours · 2026 · Related
  5. TLR4 links innate immunity and fatty acid–induced insulin resistance · Hang Shi · 2006 · 3692 citations · Cited by this paper
  6. Epigenetic Gene Networks Governing Immune State Transitions Across the Lifespan · 2026 · Related
  7. Toll-Like Receptor Signaling Pathways · Takumi Kawasaki · 2014 · 3308 citations · Cited by this paper
  8. Precision Glyco‐Modulated GcMAF2.0 Targets CLEC10A to Bidirectionally Re‐Wire Macrophage States: Cross‐Species Evidence, Mechanistic Omics and Translational Horizons · 2026 · Related
  9. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling · Luke A.J. O'Neill · 2007 · 2683 citations · Cited by this paper
  10. HIF1α Activates Glycolysis to Suppress Mycobacterium tuberculosis Growth in Mouse Bone Marrow‐Derived Macrophages · 2026 · Related
  11. Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function · María T. Abreu · 2010 · 1290 citations · Cited by this paper
  12. Methionine Regulates Antitumour Function of CD8 + T Cells Through Polyamine Synthesis · 2026 · Related
  13. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β · Jonathan C. Kagan · 2008 · 1278 citations · Cited by this paper
  14. Dual Functions of Treg in the Mucosal Barrier and Lung Cancer Microenvironment and Prospects for Targeted Therapy · 2026 · Related
  15. MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex · Holger Wesche · 1997 · 1121 citations · Cited by this paper
  16. Epidermal Dominance of Metabolically Constrained Immune Niches Underpins Immune Activation Signatures and Clinical Severity in Psoriatic Disease · 2026 · Related
  17. Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling · Su‐Chang Lin · 2010 · 1107 citations · Cited by this paper
  18. IL ‐6/ IL ‐ 6R ‐Mediated Mechanisms in Lung Cancer: From Pathogenesis to Potential Therapeutic Targets · 2026 · Related
  19. TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway · Masahiro Yamamoto · 2003 · 1060 citations · Cited by this paper
  20. Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance · 2026 · Related
  21. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4 · Masahiro Yamamoto · 2002 · 1002 citations · Cited by this paper
  22. Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling · Jonathan C. Kagan · 2006 · 863 citations · Cited by this paper
  23. Assembly and localization of Toll-like receptor signalling complexes · Nicholas J. Gay · 2014 · 845 citations · Cited by this paper
  24. TLR4 activation mediates kidney ischemia/reperfusion injury · Huiling Wu · 2007 · 837 citations · Cited by this paper
  25. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors · Tiffany Horng · 2002 · 816 citations · Cited by this paper
  26. dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway · Jeannette M. Osterloh · 2012 · 733 citations · Cited by this paper
  27. MyD88: a central player in innate immune signaling · Jacques Deguine · 2014 · 711 citations · Cited by this paper
  28. The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration · Kow Essuman · 2017 · 657 citations · Cited by this paper
  29. SARM1 activation triggers axon degeneration locally via NAD + destruction · Josiah Gerdts · 2015 · 627 citations · Cited by this paper
  30. The human adaptor SARM negatively regulates adaptor protein TRIF–dependent Toll-like receptor signaling · Michael Carty · 2006 · 547 citations · Cited by this paper
  31. Toll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-β · Zhengfan Jiang · 2004 · 389 citations · Cited by this paper
  32. SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration · Matthew D. Figley · 2021 · 354 citations · Cited by this paper
  33. Inflammatory signals regulate hematopoietic stem cells · Megan T. Baldridge · 2011 · 345 citations · Cited by this paper
  34. Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency · Vanessa Sancho‐Shimizu · 2011 · 312 citations · Cited by this paper
  35. The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction · Daniel C. Rowe · 2006 · 286 citations · Cited by this paper
  36. Mechanisms of the TRIF-induced Interferon-stimulated Response Element and NF-κB Activation and Apoptosis Pathways · Ke-Jun Han · 2004 · 247 citations · Cited by this paper
  37. Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status · Amandine Everard · 2014 · 238 citations · Cited by this paper
  38. Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides · Aubrey L. Frantz · 2012 · 227 citations · Cited by this paper
  39. Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling · Hidenori Ohnishi · 2009 · 218 citations · Cited by this paper

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